LIU Haoqiu

Research Fellow, Mechanobiology Institute, National University of Singapore

haoqiu@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Liu Haoqiu

Research Fellow

Principal Investigator

Alphée Michelot

Research Areas

Cytoskeleton organization and dynamics

Qualifications

  • PhD, Molecular and Cellular Biology, Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
  • BSc, Biotechnology, School of Life Sciences, Sichuan University, China

Biography

Haoqiu Liu studied biotechnology at Sichuan University in China and trained at the State Key Laboratory of Biotherapy under Professor Yuquan Wei. He obtained his Ph.D. from the National University of Singapore under Professor Wong Sek Man, where he developed aptamer-based probes for virus detection, patented a national invention, and uncovered a role of PI(3,5)P₂ in viral invasion through autophagy. After graduation, he continued vector–virus research with temporal–spatial transcriptomics at the NUS Suzhou Research Institute in collaboration with A*STAR GIS, and later taught high school biology, where his students won national and international awards and he received multiple teaching prizes. He subsequently pursued postdoctoral research on autophagy in Arabidopsis at the State Key Laboratory of Agrobiotechnology of the Chinese University of Hong Kong, before joining Alphée Michelot’s group at the Mechanobiology Institute, NUS, in 2025 as a Research Fellow to investigate the mechanics driving subcellular biological activities.

Technical Skills

Molecular cloning, biochemistry, cell biology, super resolution bioimaging, spatial transcriptomics, proteomics, etc.

Selected Publications

  1. Wang, H.*, Zhang, J.*, Liu, H.*, Wang, M., Dong, Y., Zhou, Y., … & Xu, Q. (2023). A plant virus hijacks phosphatidylinositol-3, 5-bisphosphate to escape autophagic degradation in its insect vector. Autophagy, 19(4), 1128-1143. *Equal contribution
  2. Liu, H., Peck, X. Y., Choong, Y. K., Ng, W. S., Engl, W., Raghuvamsi, P. V., … & Wong, S. M. (2022). Identification of putative binding interface of PI (3, 5) P2 lipid on rice black-streaked dwarf virus (RBSDV) P10 protein. Virology, 570, 81-95. (Cover article)

Recent Publications

  1. Wang, H.*, Zhang, J.*, Liu, H.*, Wang, M., Dong, Y., Zhou, Y., … & Xu, Q. (2023). A plant virus hijacks phosphatidylinositol-3, 5-bisphosphate to escape autophagic degradation in its insect vector. Autophagy, 19(4), 1128-1143. *Equal contribution
  2. Liu, H., Peck, X. Y., Choong, Y. K., Ng, W. S., Engl, W., Raghuvamsi, P. V., … & Wong, S. M. (2022). Identification of putative binding interface of PI (3, 5) P2 lipid on rice black-streaked dwarf virus (RBSDV) P10 protein. Virology, 570, 81-95. (Cover article)
  3. Liu, H., Das, P. P., Zhang, J., Yu, L., Wang, M., Lin, Q., … & Wong, S. M. (2021). iTRAQ-based quantitative proteomics suggests mitophagy involvement after Rice black-streaked dwarf virus acquisition in insect vector small brown planthopper Laodelphax striatellus Fallén. Journal of Proteomics, 246, 104314.
  4. Liu, H., Zhou, Y., Xu, Q., & Wong, S. M. (2020). Selection of DNA aptamers for subcellular localization of RBSDV P10 protein in the midgut of small brown planthoppers by emulsion PCR-based SELEX. Viruses, 12(11), 1239.
  5. Wu, W., Liu, H., Dong, Y., Zhang, Y., Wong, S. M., Wang, C., … & Xu, Q. (2019). Determination of suitable RT-qPCR reference genes for studies of gene functions in Laodelphax striatellus (Fallén). Genes, 10(11), 887.
  6. Xu, Q., Liu, H., Yuan, P., Zhang, X., Chen, Q., Jiang, X., & Zhou, Y. (2017). Development of a simplified RT-PCR without RNA isolation for rapid detection of RNA viruses in a single small brown planthopper (Laodelphax striatellus Fallén). Virology journal, 14(1), 90.

Other Professional Involvements

  • Member of Chinese Society for Plant Biology