Marius SUDOL

Co-Principal Investigator, Mechanobiology Institute, National University of Singapore

mbims@nus.edu.sg | phsms@nus.edu.sg
+65 6601 1402
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Curriculum Vitae

Research Program
The Cell-Matrix and Cell-Cell Mechanotransduction Group

Affiliations
Associate Professor, Yong Loo Lin School of Medicine, Department of Physiology, NUS, Institute for Molecular and Cell Biology (IMCB, AStar)

Marius Sudol

Co-Principal Investigator

Research Areas

• Investigations into physiological and molecular mechanisms of the Golabi-Ito-Hall syndrome, which phenocopies severe autism, using transgenic animal models of the syndrome
• Investigations into the role of tight junctions proteins such as ZO2 and ZO1 in the regulation of the Hippo-YAP tumor suppressor pathway using cell and animal models
• Investigations of new signaling modalities that inhibit YAP oncogene and could be translated into cancer drug discovery
• Investigations of a cross talk between WW domain-containing proteins that regulate muscle homeostasis and the Hippo-YAP pathway that controls differentiation and stem cell biology
• Investigations into the dominant role of Hippo-YAP tumor suppressor pathway in liver regeneration

Research Interests

Among Prof Sudol’s most significant achievements to date are the identification of a modular protein domain, known as the WW domain, and the characterization of its cognate ligands. In 2004, together with a research team at AxCell-Cytogen company, Marius Sudol reported the first comprehensive protein interaction map for a human modular domain. Today, the WW domain is known to mediate critical signals in tumor suppressor networks, including the Hippo signaling pathway. More importantly, syndromes such as the Golabi-Ito-Hall syndrome of intellectual disability and Liddle syndrome of hypertension are caused by loss-of-function point mutations in the WW domain or its cognate ligands.

Biography

The research conducted in Marius Sudol’s laboratory and those of his collaborators over the past two decades has directly contributed to a systems biology level understanding of signaling networks from the perspective of modular protein domains. As a co-founder and co-leader of the Protein Modules Consortium, he advocates systems biology approaches and synthetic biology strategies in designing therapeutic interventions based on the knowledge of the structure and function of protein modules.

Over the course of his scientific career spanning more than three decades, Marius Sudol has authored 130 publications, including original research articles and invited reviews in refereed journals as well as numerous book chapters. His current work focuses on the role of WW domain-containing proteins in the Hippo tumor suppressor network and Golabi-Ito-Hall syndrome of intellectual disability.

Education

PhD The Rockefeller University, New York City, USA

Recent Publications