MBI Weekly Meeting Seminar
Time: 9.30am-10.30am
Date: Friday, 8 March 2019
Venue: Level 5 Seminar Room, T-Lab
Imaging Synapses: From Molecule to Function
by Prof. Jun Nishiyama, Assistant Professor, Duke-NUS Medical School
Our brain functions depend on connections between billions of neurons. These connections or synapses are believed to be disrupted in many neuropsychiatric disorders such as autism, schizophrenia, and Alzheimer’s disease. However, molecular mechanisms underlying synaptic function and dysfunction are largely unknown. In this seminar, I will introduce our studies to probe endogenous proteins and image signal transduction in single synapses using cutting-edge genome editing and various optical techniques. I will discuss how these tools can help to understand molecular regulation of synapses.
References
1) Nishiyama, J.*, Mikuni, T*,†., Yasuda R†. Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain. Neuron, 96, 755-768 (2017).
2) Mikuni, T.*, Nishiyama, J.*,†, Sun Y., Kamasawa N., Yasuda, R.† High-Throughput, High-Resolution Mapping of Protein Localization in Mammalian Brain by In Vivo Genome Editing. Cell, 165 1803-17 (2016).
3) Nishiyama, J. and Yasuda, R. Biochemical Computation for Spine Structural Plasticity. Neuron, 87 63-75 (2015).
