MBI Weekly Seminar

Time: 5.00pm – 6.00pm
Date: Friday, 4 December 2020
Venue: Online seminar via ZOOM

Cellular and molecular force regulation by receptor-mediated interactions

E. Ada Cavalcanti, Group Leader, Max Planck Institute for Medical Research, Germany

Mechanical and chemical properties of the extracellular environment regulate cell adhesion and migration.  Designing materials and tools which allow the local control of cell-matrix and cell-cell adhesion is of great interest to address how specific receptor-ligand interactions affect cell mechanotransduction. I will present the development of surface functionalization strategies to control integrin clustering for the generation of molecular and cellular forces at the interface during adhesion. I will also discuss the crosstalk between integrins and growth factors in the regulation of cell adhesion and mechanotransduction signaling.

In the last part of my talk, I will introduce the application of opto-chemical tools to control the assembly and disassembly of E-cadherin-mediated cell-cell junctions and the impact on collective cell dynamics and forces.

MBI Weekly Seminar Fully Webcasted 
The access link and password will be sent to you on the day of seminar via email.  If you need help connecting, contact MBI ITCore at mbit@nus.edu.sg.