Please be informed of MBI Weekly Meeting Seminar this Friday, 2 December as follows:

Time: 9:30am
Venue: T-Lab Level 5 Seminar Room
Presenter: Virgile Viasnoff
Talk Title: “How does microenvironment influence Apico basal polarity”

Abstract: The importance of the biophysical cues of cellular microniches in the context of tissue homeostasis and diseases are being progressively uncovered. We present here a set of new methodological approaches that allows to precisely control in vitro the environmental parameters surrounding 1 to 100 cells in a combinatorial way. Our approach also permits 3D super resolution imaging of cells across the entire cell body. We illustrate how this techniques can be used to induce  apico-basal polarity of a single cell in the context of epithelial cells and hepatocytes. Lastly, we explore how local application of mechanical stresses contributes to the localization and  maturation of the tight junction belt.