MBI PhD Qualifying Exam
Time: 1pm
Date: 21 Feb 2019, Thursday
Venue: NUS, E4-04-04.
Supervisor: Dr Timothy Saunders
Computer-Driven Analysis of Developing Biological Systems
By Tricia LOO Yi Jun, Timothy Saunder’s Group
The developing organism undergoes many complex changes that are challenging to observe in vivo. Therefore, computational methods are required to fully visualise, quantify and explore the process of morphogenesis. While recent advancements in experimental and microscopy techniques have increased the accessibility of high quality data, there is now a corresponding greater need for new computational tools that are able to take full advantage of these high-quality datasets and technological improvements. Here, we present three projects being carried out to produce tools relevant to studying the process of morphogenesis during development. First, we have created a MATLAB routine for aligning multichannel 3D time-lapse images that undergo complex shape changes. Secondly, we have begun to develop models that combine domain growth with tissue patterning processes. Lastly, we look into applying machine learning to predict biophysical models and parameters from imaging data. Taken together, these projects represent an effort to apply robust computational methods towards understanding how complex 3D patterns are formed during embryonic development.
**Please note the examination following the seminar is closed-door**
