PhD Qualifying Examination

Role of BNIP-2 scaffold protein in cardiomyocyte signaling and differentiation

Speaker          :   Darren, WONG Chen Pei (Graduate Student, MBI, NUS)
Date                :   27 Mar 2017, Monday
Time                :   10am
Venue             :   MBI, level 5 meeting rooms

Supervisor(s)  :  Prof LOW Boon Chuan (main supervisor) and Asst. Prof KANCHANAWONG Pakorn (co-supervisor)

Abstract: Cardiovascular diseases is a leading cause of death while the human heart has limited regenerative potential. Lost cardiomyocytes are replaced by diseased myofibroblast which can recruit inflammatory cells and secret factors that modifies the extra cellular matrix of the heart. Altered rigidity can affect the function and  the limited regenerative stem cell populations in the heart. This study  aims at understanding  how cardiomyocyte differentiation can be modulated by BNIP-2,  a versatile signaling scaffold protein in integrating mechanical signals to  the biochemical changes in these cells. Understanding the biochemical and mechanical factors that influence cardiomyocyte differentiation may  direct differentiation of stem cells to mature cardiomyocytes.

ALL EXCEPT PANEL ARE EXCUSED FOR CLOSE DOOR EXAMINATION