Aaron Joseph Farrugia

Senior Research Fellow, Mechanobiology Institute, National University of Singapore

mbiajf@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Aaron Joseph Farrugia

Senior Research Fellow

Principal Investigator

Alexander Bershadsky

Research Interests

  • Cell-cell and cell-matrix adhesion
  • Cytoskeletal dynamics
  • Angiogenesis and Tumour microenvironment

Qualifications

  • PhD, Cancer Biology, Institute of Cancer Research – University of London
  • MSc, Applied Biomolecular Technology, University of Nottingham
  • BSc(Hons), Medical Laboratory Science, University of Malta

Selected Publications

  1. Farrugia, A. J., Rodriguez, J., Orgaz, J. L., Lucas, M., Sanz-Moreno, V., & Calvo, F. (2020). CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion. J Cell Biol, 219(9). https://doi.org/10.1083/jcb.201912159
  2. Perone, Y.*, Farrugia, A. J.*, Rodriguez-Meira, A.*, Gyorffy, B., Ion, C., Uggetti, A., . . . Magnani, L. (2019b). SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERalpha breast cancer. Nat Commun, 10(1), 2115. https://doi.org/10.1038/s41467-019-09676-y (*co-first author)

Recent Publications

  1. Aureille J, Prabhu SS, Barnett SF, Farrugia AJ, Arnal I, Lafanechère L, Low BC, Kanchanawong P, Mogilner A, and Bershadsky AD. Focal adhesions are controlled by microtubules through local contractility regulation. EMBO J 2024;. [PMID: 38769437]
  2. Lin S, Changede R, Farrugia AJ, Bershadsky AD, Sheetz MP, Prost J, and Rupprecht J. Membrane Tilt Drives Phase Separation of Adhesion Receptors. Phys Rev Lett 2024; 132(18):188402. [PMID: 38759206]
  3. Seetharaman S, Vianay B, Roca V, Farrugia AJ, De Pascalis C, Boëda B, Dingli F, Loew D, Vassilopoulos S, Bershadsky A, Théry M, and Etienne-Manneville S. Microtubules tune mechanosensitive cell responses. Nat Mater 2021;. [PMID: 34663953]