Benoit LADOUX
Visiting Faculty, Mechanobiology Institute, National University of Singapore, Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Laboratory website
Cell Adhesion and Mechanics Lab
Research Program
Mechanotransduction in Tissues Group
Affiliations
Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
What is tensin?
What is tensin? Tensin is a cytoskeleton scaffolding protein that was named for its ability to form a bridge that maintains tension between the actin filaments and cell-matrix adhesion sites (reviewed in [1]). A [...]
How is SRF signaling activated?
How is SRF signaling activated? Myocardin, MAL (or MRTF-A) and MRTF-B are the best-studied examples of MRTFs. In the cytoplasm, MRTFs exist in a stable complex with monomeric G-actin via RPEL domains, which exist [...]
What is the Hippo-YAP/TAZ tumor-suppressor pathway?
What is the Hippo-YAP/TAZ tumor-suppressor pathway? Mechanical cues control Hippo-YAP/TAZ tumor-suppressor pathway The Hippo signaling pathway is a complex network of proteins that controls organ size via regulation of cellular proliferation, survival and differentiation. [...]
What are guidance cues?
What are guidance cues? During neural development, highly motile structures on the developing neurites, called growth cones, are guided by signals from the extracellular environment. Guidance cues come in many different forms, from diffusible [...]
What is integrin extension?
What is integrin extension? Integrin extension Upon alteration in the transmembrane and their proximal domains, the bent headpiece extends in less than 1 second [1] with intermediate affinity for ligands. Two models- “switchblade” and [...]
What ligands bind to integrin?
What ligands bind to integrin? Integrin-Ligand specificity Humans have at least 18 α subtypes and 8 β subtypes which together generate 24 known binding pairs for the integrins heterodimer (reviewed in [1][2]). The α [...]
Benoit Ladoux
Visiting Faculty
Research Areas
Epithelial cell migration; microfabrication for cell mechanics; influence of the mechanical environments on cell functions; mechanotransduction
Research Interests
Our research aims at understanding how living organisms interact with their environment. In particular, we are studying the cooperation between adhesion, biomechanical and biochemical signaling for the adaptation of living organisms to changes in their environment. To probe these questions, our laboratory has developed a repertoire of micro- and nano-fabrication tools to control and measure the chemical and mechanical environment of cells. Our research programme thus focuses on the integration of novel microfabricated devices for the quantitative imaging of living organisms.
Biography
With a background in Physics, Prof Ladoux started his career at Curie Institute working on single molecule biophysics. He worked on two main problems combining statistical physics, microfabrication and molecular biology: 1) chromatin condensation in real time; 2) fluctuations of a single polymer under shear flows. After a post-doc on cell mechanics, he used his knowledge in biophysics and microfabrication to start a new subject on mechanical studies of cell migration and adhesion at the University Paris Diderot. He developed microsystems to characterise the mechanical interactions of cells with their migration support. He is currently working on rigidity sensing, collective cell migration and tissue homeostasis.
Recent Publications
- Shiratsuchi N, Fujita Y, Simon de Beco , Daubech C, Ladoux B, Grata A, Levayer R, Magny E, O'Brien LE, Priya R, Mitchell SJ, Rosenblatt J, Rupprecht J, Stockmann L, Sedzinski J, Roquin L, Suzanne M, Toyama Y, Matekcic M, Trepat X, Vinzens S, Wickström SA, Lwin AKO, and Yap AS. Meeting report - CellExIt#1, the first international symposium on cell extrusion. J Cell Sci 2026; 139(14). [PMID: 42504880]
- Balasubramaniam L, Monfared S, Ardaševa A, Rosse C, Schoenit A, Dang T, Maric C, Hautefeuille M, Kocgozlu L, Chilupuri R, Dubey S, Marangoni E, L Doss B, Chavrier P, Mège R, Doostmohammadi A, and Ladoux B. Dynamic forces shape the survival fate of eliminated cells. Nat Phys 2025;. [PMID: 40636322]
- Kawaue T, Yow I, Pan Y, Le AP, Lou Y, Loberas M, Shagirov M, Teng X, Prost J, Hiraiwa T, Ladoux B, and Toyama Y. Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Dev Cell 2023;. [PMID: 36800994]
- Sonam S, Balasubramaniam L, Lin S, Ivan YMY, Jaumà IP, Jebane C, Karnat M, Toyama Y, Marcq P, Prost J, Mège R, Rupprecht J, and Ladoux B. Mechanical stress driven by rigidity sensing governs epithelial stability. Nat Phys 2022; 19:132-141. [PMID: 36686215]
- Rose N, Estrada Chavez B, Sonam S, Nguyen T, Grenci G, Bigot A, Muchir A, Ladoux B, Cadot B, Le Grand F, and Trichet L. Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials 2022; 293:121935. [PMID: 36584444]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Yang Y, Nguyen E, Sankara Narayana GHN, Heuzé M, Fu C, Yu H, Mège R, Ladoux B, and Sheetz MP. Local contractions regulate E-cadherin rigidity sensing. Sci Adv 2022; 8(4):eabk0387. [PMID: 35089785]
- . https://www.ncbi.nlm.nih.gov/pubmed/33850145
- Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, and Trepat X. Addendum: Active superelasticity in three-dimensional epithelia of controlled shape. Nature 2021;. [PMID: 33846613]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
Lab Members
Sun Zijun
Alumni, Toyama Group
A Molecular Rivet
A molecular rivet for long-range force transmission
Artem Yefremov
Alumni, Visiting Senior Research Fellow, Yan Jie Lab
Ranjit S Gulvady
Alumni, Yan Jie Group
Ladislav Hovan
Alumni, Yan Jie Group, Sudol Group
Guo Shiwen
Alumni, PhD Student, Class of August 2015, Yan Jie Group
Le Shimin
Dept of Physics, Yan Jie Group
Yu Miao
Research Fellow, Yan Jie Group
Zhao Xiao Dan
Research Fellow, Yan Jie Alumni
Liu Meihan
Alumni, Yan Jie Group
Yang Kaiyuan
Alumni, Yan Jie Group
Zhou Yu
Research Fellow, Yan Jie Group
