Benoit LADOUX
Visiting Faculty, Mechanobiology Institute, National University of Singapore, Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Laboratory website
Cell Adhesion and Mechanics Lab
Research Program
Mechanotransduction in Tissues Group
Affiliations
Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
What is cell polarity?
What is cell polarity? Cell polarity refers to the intrinsic asymmetry observed in cells, either in their shape, structure, or organization of cellular components. Most epithelial cells, migrating cells and developing cells require some [...]
What is cell migration?
What is cell migration? Cell migration is the directed movement of a single cell or a group of cells in response to chemical and/or mechanical signals. It is a fundamental cellular process that occurs [...]
What are epithelial tubes?
What are epithelial tubes? Tubulogenesis, or the formation of tubes, is one of the fundamental morphogenetic events taking place during development. Several major organs, such as the respiratory, circulatory, and secretory systems, are constituted [...]
How is dorsal closure controlled by mechanics?
How is dorsal closure controlled by mechanics? A number of studies, which describe the cellular mechanisms and signaling pathways underlying dorsal closure, have pointed towards a mechanical basis for the morphogenetic changes associated with [...]
How does the vascular system form?
How does the vascular system form? What is vasculogenesis? Vasculogenesis refers to the morphogenetic process occurring during the earliest stages of embryonic development by which a de novo vascular system, consisting of the heart [...]
How do cardiomyocytes differentiate?
How do cardiomyocytes differentiate? Cardiomyocytes are the chief cell type in the heart and their coordinated contraction as a mass is responsible for the pumping of blood around the developing embryo. Cardiac specification occurs [...]
Benoit Ladoux
Visiting Faculty
Research Areas
Epithelial cell migration; microfabrication for cell mechanics; influence of the mechanical environments on cell functions; mechanotransduction
Research Interests
Our research aims at understanding how living organisms interact with their environment. In particular, we are studying the cooperation between adhesion, biomechanical and biochemical signaling for the adaptation of living organisms to changes in their environment. To probe these questions, our laboratory has developed a repertoire of micro- and nano-fabrication tools to control and measure the chemical and mechanical environment of cells. Our research programme thus focuses on the integration of novel microfabricated devices for the quantitative imaging of living organisms.
Biography
With a background in Physics, Prof Ladoux started his career at Curie Institute working on single molecule biophysics. He worked on two main problems combining statistical physics, microfabrication and molecular biology: 1) chromatin condensation in real time; 2) fluctuations of a single polymer under shear flows. After a post-doc on cell mechanics, he used his knowledge in biophysics and microfabrication to start a new subject on mechanical studies of cell migration and adhesion at the University Paris Diderot. He developed microsystems to characterise the mechanical interactions of cells with their migration support. He is currently working on rigidity sensing, collective cell migration and tissue homeostasis.
Recent Publications
- Shiratsuchi N, Fujita Y, Simon de Beco , Daubech C, Ladoux B, Grata A, Levayer R, Magny E, O'Brien LE, Priya R, Mitchell SJ, Rosenblatt J, Rupprecht J, Stockmann L, Sedzinski J, Roquin L, Suzanne M, Toyama Y, Matekcic M, Trepat X, Vinzens S, Wickström SA, Lwin AKO, and Yap AS. Meeting report - CellExIt#1, the first international symposium on cell extrusion. J Cell Sci 2026; 139(14). [PMID: 42504880]
- Balasubramaniam L, Monfared S, Ardaševa A, Rosse C, Schoenit A, Dang T, Maric C, Hautefeuille M, Kocgozlu L, Chilupuri R, Dubey S, Marangoni E, L Doss B, Chavrier P, Mège R, Doostmohammadi A, and Ladoux B. Dynamic forces shape the survival fate of eliminated cells. Nat Phys 2025;. [PMID: 40636322]
- Kawaue T, Yow I, Pan Y, Le AP, Lou Y, Loberas M, Shagirov M, Teng X, Prost J, Hiraiwa T, Ladoux B, and Toyama Y. Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Dev Cell 2023;. [PMID: 36800994]
- Sonam S, Balasubramaniam L, Lin S, Ivan YMY, Jaumà IP, Jebane C, Karnat M, Toyama Y, Marcq P, Prost J, Mège R, Rupprecht J, and Ladoux B. Mechanical stress driven by rigidity sensing governs epithelial stability. Nat Phys 2022; 19:132-141. [PMID: 36686215]
- Rose N, Estrada Chavez B, Sonam S, Nguyen T, Grenci G, Bigot A, Muchir A, Ladoux B, Cadot B, Le Grand F, and Trichet L. Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials 2022; 293:121935. [PMID: 36584444]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Yang Y, Nguyen E, Sankara Narayana GHN, Heuzé M, Fu C, Yu H, Mège R, Ladoux B, and Sheetz MP. Local contractions regulate E-cadherin rigidity sensing. Sci Adv 2022; 8(4):eabk0387. [PMID: 35089785]
- . https://www.ncbi.nlm.nih.gov/pubmed/33850145
- Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, and Trepat X. Addendum: Active superelasticity in three-dimensional epithelia of controlled shape. Nature 2021;. [PMID: 33846613]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
Lab Members
Building heart connections
How heart cells find their partners
Jean-Baptiste Sibarita
A/Prof Sibarita of Université de Bordeaux will be visiting from from 6 August, 2018 – 5 August, 2019.
Samuel Fardell Hastings Barnett
Alumni, Kanchanawong Group
Lai Kuan Han, Jason
Alumni, Saunders Group
Predicting DNA-protein interactions
Fast quantification of DNA-protein interactions under force and torque constraints
MBI Women in Science at the Gender Summit 2018, London
Dr. Vandana Ramachandran (A*STAR; SgWIS) and Dr. Lakshmi Ramachandran (STEM Advocacy Institute; MBI-WIS) will present a talk on ‘ Singapore as host of the next Gender Summit – Asia Pacific, GS-AP 2019’ at the Gender Summit 15 EU 2018 plenary session on 19th June, London.
EMBO Workshop on Nuclear Mechanogenomics: Post-event report
The EMBO Workshop on Nuclear Mechanogenomics was held on April 17-20 at the Shaw Foundation Alumni House, National University of Singapore. The workshop brought together pioneering academics, early career scientists and post-doctoral and graduate scholars to discuss the latest advancements and challenges facing the rapidly emerging field of nuclear mechanogenomics.
Physically rewiring the genome
Researchers turn mature cells into stem cells using mechanical cues alone
Teng Xiang
Research Associate, Toyama Group
Thiagarajan Visalatchi
Research Associate, Bershadsky Group
Interdisciplinary short course for new graduate students: A case study
Interdisciplinary short course for new graduate students: A case study
Professor Lim Chwee Teck and team awarded the Human Frontier Science Program Research Grant
MBInsights Home Science Features News Awards Outreach Events Awards Professor Lim Chwee Teck and team awarded the Human Frontier Science Program Research Grant MBI SCI COMS [...]
