Yusuke HARA
Alumni, Mechanobiology Institute, National University of Singapore
mbiyusu@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
How do small GTPases regulate mechanosignaling pathways?
How do small GTPases regulate mechanosignaling pathways? The small GTPases are a superfamily of enzymes that function as ‘molecular switches’ and are involved in regulating many cellular processes. All small GTPases transduce information through [...]
Are focal adhesions dynamic?
Are focal adhesion dynamic? In migrating cells, turnover of adhesion components happens throughout the adhesion life cycle, with a shift in equilibrium between rates of recruitment and removal during the various stages. At the [...]
What are focal adhesions?
What are focal adhesions? Focal adhesions are integrin-containing, multi-protein structures that form mechanical links between intracellular actin bundles and the extracellular matrix or substrate in many cell types [1]. The formation and function of [...]
What are Ras GTPases?
What are Ras GTPases? The Ras family of small GTPases were originally discovered during a search for oncogenic retroviruses. Named for their ability to cause rat sarcomas, human RAS genes were identified in 1982 [...]
What are Ran GTPases?
What are Ran GTPases? The Ran (Ran-related or Ras-like nuclear) protein is the single member of the Ran subfamily, and the most abundant small GTPase in the cell. Like the other small GTPases, Ran [...]
What are Rab GTPases?
What are Rab GTPases? The Rab proteins constitute the largest family of small GTPases belonging to the Ras superfamily, with approximately 70 members identified in humans. Rab GTPases are the primary regulators of the [...]
Yusuke Hara
Alumni
Recent Publications
- Sun Z, Amourda C, Shagirov M, Hara Y, Saunders TE, and Toyama Y. Author Correction: Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension. Nat. Cell Biol. 2018;. [PMID: 29507405]
- Hara Y. Contraction and elongation: Mechanics underlying cell boundary deformations in epithelial tissue. Dev. Growth Differ. 2017;. [PMID: 28573735]
- Ding WY, Ong HT, Hara Y, Wongsantichon J, Toyama Y, Robinson RC, Nédélec F, and Zaidel-Bar R. Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis. J. Cell Biol. 2017;. [PMID: 28400443]
- Sun Z, Amourda C, Shagirov M, Hara Y, Saunders TE, and Toyama Y. Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension. Nat. Cell Biol. 2017;. [PMID: 28346438]
- Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, Baird MA, Davidson MW, Zaidel-Bar R, Toyama Y, Ladoux B, Mege R, and Kanchanawong P. Nanoscale architecture of cadherin-based cell adhesions. Nat. Cell Biol. 2016;. [PMID: 27992406]
- Hara Y, Shagirov M, and Toyama Y. Cell Boundary Elongation by Non-autonomous Contractility in Cell Oscillation. Curr. Biol. 2016; 26(17):2388-96. [PMID: 27524484]
