Toyama Group

Yusuke HARA

Alumni, Mechanobiology Institute, National University of Singapore

mbiyusu@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

What is the role of cadherin and nectin recruitment in adherens junction assembly?

What is the role of cadherin and nectin recruitment in adherens junction assembly? Cadherin Recruitment Type I cadherins, also known as classical cadherins, are commonly found in adherens junctions (AJs) and desmosomes. They are [...]

By Management|Nov 30th, 2023|Categories: MBInfo, Mechanosignaling|Comments Off on What is the role of cadherin and nectin recruitment in adherens junction assembly?

How does integrin clustering affect integrin signalling?

How does integrin clustering affect integrin signaling? Localization of Integrin The concentration of β subunits is generally high while that of α subunit is the factor limiting the amount of heterodimers that localize on [...]

By Management|Nov 30th, 2023|Categories: MBInfo, Mechanosignaling|Comments Off on How does integrin clustering affect integrin signalling?

What is talin?

What is talin? Talin contains a 47-kDa N-terminal head, a neck and a 220kDa rod domain. The head domain comprises four subdomains termed F0, F1, F2 and F3, with the latter three forming a [...]

By Management|Nov 30th, 2023|Categories: MBInfo, Mechanosignaling|Comments Off on What is talin?

What is parvin?

What is parvin? The parvins are a family of actin binding proteins (known as α-, β- and γ-parvin in mammals) that are members of the actin linking functional module at cell-matrix adhesion sites (reviewed [...]

By Management|Nov 30th, 2023|Categories: MBInfo, Mechanosignaling|Comments Off on What is parvin?

What are cell-matrix receptors?

What are cell-matrix receptors? Interaction between cell-matrix receptors and their respective ligands are often the initial step in the formation of a cell-matrix adhesion. Several types of cell-matrix receptors have been identified, each interacting [...]

By Management|Nov 30th, 2023|Categories: MBInfo, Mechanosignaling|Comments Off on What are cell-matrix receptors?

Yusuke Hara

Alumni

Principal Investigator

Yusuke Toyama

Research Interests

Mechanotransduction in Tissues

Recent Publications

  1. Sun Z, Amourda C, Shagirov M, Hara Y, Saunders TE, and Toyama Y. Author Correction: Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension. Nat. Cell Biol. 2018;. [PMID: 29507405]
  2. Hara Y. Contraction and elongation: Mechanics underlying cell boundary deformations in epithelial tissue. Dev. Growth Differ. 2017;. [PMID: 28573735]
  3. Ding WY, Ong HT, Hara Y, Wongsantichon J, Toyama Y, Robinson RC, Nédélec F, and Zaidel-Bar R. Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis. J. Cell Biol. 2017;. [PMID: 28400443]
  4. Sun Z, Amourda C, Shagirov M, Hara Y, Saunders TE, and Toyama Y. Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension. Nat. Cell Biol. 2017;. [PMID: 28346438]
  5. Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, Baird MA, Davidson MW, Zaidel-Bar R, Toyama Y, Ladoux B, Mege R, and Kanchanawong P. Nanoscale architecture of cadherin-based cell adhesions. Nat. Cell Biol. 2016;. [PMID: 27992406]
  6. Hara Y, Shagirov M, and Toyama Y. Cell Boundary Elongation by Non-autonomous Contractility in Cell Oscillation. Curr. Biol. 2016; 26(17):2388-96. [PMID: 27524484]
By Management|2018-02-20T13:14:57+08:00Apr 20th, 2017|Categories: Alumni, Toyama Alumni|Comments Off on Yusuke Hara

About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
Go to Top