WANG Yejun
Alumni, Mechanobiology Institute, National University of Singapore
mbiwye@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What is the plasma membrane?
What is the plasma membrane? Plasma membranes are subcellular structures, approximately 10nm thick, that form a protective boundary around the cell as well as the cell’s organelles. They serve to both impede foreign material [...]
How do mechanically-gated ion channels facilitate mechanotransduction?
How do mechanically-gated ion channels facilitate mechanotransduction? Mechanotransduction relies on the ability of cells to convert mechanical cues, such as stretch or compression, to biochemical signals. One way this occurs is through the activity [...]
How do lipid bilayer components move?
How do lipid bilayer components move? One of the tenets of the Fluid-Mosaic membrane model is that the components of the bilayers are free to move. Before describing the differences between lipid and protein [...]
Why are membrane lipids asymmetrical?
Why are membrane lipids asymmetrical? The human red blood cell is functionally specialized for transporting oxygen. In order to maximize oxygen capacity, it has no nucleus or organelles, consisting primarily of plasma membrane and [...]
What is Myosin Light Chain Kinase?
What is Myosin Light Chain Kinase? Myosin light chain kinase (MLCK) is a calcium/calmodulin-dependent serine/threonine kinase, belonging to the immunoglobulin superfamily. It phosphorylates the regulatory myosin light chains of myosin II, in order to [...]
How does the clathrin coated pit form?
How does the clathrin coated pit form? Adaptor proteins such as AP-2, AP180 and CALM (Clathrin-assembly lymphoid myeloid leukaemia protein), which accumulate within the lipid bilayer, are responsible for the recruitment of the triskelion [...]
Wang Yejun
Alumni
I decided to switch into the world of biology after I received my BS in chemistry from Zhejiang University. With the interest in things happening inside nucleus, I joined Prof. Shiva’s lab as a graduate student, to study the role of external mechanical signals on gene regulation in eukaryotic cells. During my first one and a half years I developed a method to visualize active transcription sites on open chromatin spreads using super-resolution microscopy. Presently I’m studying the role of cell geometric constraints on 3D organization of chromosomes by using multiple techniques such as fluorescence in situ hybridization (FISH), confocal imaging, and super-resolution imaging.
Recent Publications
- Wang Y, Li X, Xia R, Wan Y, Lu J, Zhao Z, Zhang W, Wang Q, Saunders TE, and Yin J. Hedgehog-driven adaxial cell constriction patterns slow muscle fate and somite boundary remodeling in the presomitic mesoderm. Cell Rep 2026; 45(5):117319. [PMID: 42065961]
- Yang J, Guan Z, Zeng D, Qin Y, Zhao C, Wang S, Wu Q, Wang Q, Li H, Wu J, Huang H, Wang Y, Wu E, Thalmann NM, Lim CT, Wong TY, Jia W, Li H, Fregni F, and Sheng B. Extended reality in clinical neurology: From interdisciplinary innovations to clinical practice. Cell Rep Med 2026;:102696. [PMID: 41903546]
- Yang B, Li B, Zhu Y, Zhao M, Cheng Y, Zhao X, En-Jie DT, Wang Y, Zhang M, Tang X, Jin S, Sun Y, Zhang X, Xue B, Yan J, Wu G, Lin Z, Luo M, Yu H, Zhang L, Chen X, and Ni Q. Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production. Nat Nanotechnol 2026;. [PMID: 41772191]
- Liu X, Liu J, Wang Y, Yao M, Baker KB, Klapholz B, Brown NH, Goult BT, and Yan J. The mechanical response of vinculin. Sci Adv 2025; 11(44):eady6949. [PMID: 41171905]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Wang W, Huang Z, Wang Y, Li H, and Kanchanawong P. Vortex Interference Enables Optimal 3D Interferometric Nanoscopy. Phys Rev Lett 2025; 134(7):073802. [PMID: 40053988]
- Wang Y, Wang Y, Zhu Y, Yu P, Zhou F, Zhang A, Gu Y, Jin R, Li J, Zheng F, Yu A, Ye D, Xu Y, Liu Y, Saw TB, Hu G, Lim CT, and Yu F. Angiomotin cleavage promotes leader formation and collective cell migration. Dev Cell 2024;. [PMID: 39389053]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Morales-Camilo N, Liu J, Ramírez MJ, Canales-Salgado P, Alegría JJ, Liu X, Ong HT, Barrera NP, Fierro A, Toyama Y, Goult BT, Wang Y, Meng Y, Nishimura R, Fong-Ngern K, Low CSL, Kanchanawong P, Yan J, Ravasio A, and Bertocchi C. Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction. Nat Commun 2024; 15(1):5608. [PMID: 38969637]
- Zhang X, Ruan L, Wang H, Zhu J, Li T, Sun G, Dong Y, Wang Y, Berreby G, Shay A, Chen R, Ramachandran S, Dawson VL, Dawson TM, and Li R. Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity. NPJ Parkinsons Dis 2024; 10(1):120. [PMID: 38906862]
