WANG Yejun
Alumni, Mechanobiology Institute, National University of Singapore
mbiwye@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
How are intermediate filaments assembled?
How are intermediate filaments assembled? The soluble subunit for creating intermediate filaments is a tetramer. The tetramer is created from monomers in a stepwise fashion (as reviewed in [1]). First, two monomers associate via [...]
What are microtubules?
What are microtubules? Microtubules are hollow cylinders [1] that are approximately 25nm in diameter [2] and vary in length from 200 nm to 25 μm. They are formed by the lateral association of between [...]
What are intermediate filaments?
What are intermediate filaments? Intermediate filaments are a primary component of the cytoskeleton, although they are not found in all eukaryotes, and are absent in fungi and plants [1]. These filaments, which extend throughout [...]
How is actomoysin contractility regulated?
How does the contractome protein network regulate actomyosin contractility? Non-muscle myosin II isoforms have a similar structure and function to their muscle equivalents. However, their interaction with actin serves to generate cellular forces rather [...]
What is Actomyosin?
What is Actomyosin? Actomyosin refers to the actin-myosin complex that forms within the cytoskeleton. Actomyosin is inherently contractile, with the myosin motor protein able to pull on actin filaments. This property gives rise to [...]
What are Contractile Fibers?
What are Contractile Fibers? Certain myosin isoforms (i.e. myosin II) form bipolar assemblies via the extended coiled-coil domains in the heavy chains (see also “thick filaments”). Actin “thin filaments” with opposite polarity associate with [...]
Wang Yejun
Alumni
I decided to switch into the world of biology after I received my BS in chemistry from Zhejiang University. With the interest in things happening inside nucleus, I joined Prof. Shiva’s lab as a graduate student, to study the role of external mechanical signals on gene regulation in eukaryotic cells. During my first one and a half years I developed a method to visualize active transcription sites on open chromatin spreads using super-resolution microscopy. Presently I’m studying the role of cell geometric constraints on 3D organization of chromosomes by using multiple techniques such as fluorescence in situ hybridization (FISH), confocal imaging, and super-resolution imaging.
Recent Publications
- Wang Y, Li X, Xia R, Wan Y, Lu J, Zhao Z, Zhang W, Wang Q, Saunders TE, and Yin J. Hedgehog-driven adaxial cell constriction patterns slow muscle fate and somite boundary remodeling in the presomitic mesoderm. Cell Rep 2026; 45(5):117319. [PMID: 42065961]
- Yang J, Guan Z, Zeng D, Qin Y, Zhao C, Wang S, Wu Q, Wang Q, Li H, Wu J, Huang H, Wang Y, Wu E, Thalmann NM, Lim CT, Wong TY, Jia W, Li H, Fregni F, and Sheng B. Extended reality in clinical neurology: From interdisciplinary innovations to clinical practice. Cell Rep Med 2026;:102696. [PMID: 41903546]
- Yang B, Li B, Zhu Y, Zhao M, Cheng Y, Zhao X, En-Jie DT, Wang Y, Zhang M, Tang X, Jin S, Sun Y, Zhang X, Xue B, Yan J, Wu G, Lin Z, Luo M, Yu H, Zhang L, Chen X, and Ni Q. Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production. Nat Nanotechnol 2026;. [PMID: 41772191]
- Liu X, Liu J, Wang Y, Yao M, Baker KB, Klapholz B, Brown NH, Goult BT, and Yan J. The mechanical response of vinculin. Sci Adv 2025; 11(44):eady6949. [PMID: 41171905]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Wang W, Huang Z, Wang Y, Li H, and Kanchanawong P. Vortex Interference Enables Optimal 3D Interferometric Nanoscopy. Phys Rev Lett 2025; 134(7):073802. [PMID: 40053988]
- Wang Y, Wang Y, Zhu Y, Yu P, Zhou F, Zhang A, Gu Y, Jin R, Li J, Zheng F, Yu A, Ye D, Xu Y, Liu Y, Saw TB, Hu G, Lim CT, and Yu F. Angiomotin cleavage promotes leader formation and collective cell migration. Dev Cell 2024;. [PMID: 39389053]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Morales-Camilo N, Liu J, Ramírez MJ, Canales-Salgado P, Alegría JJ, Liu X, Ong HT, Barrera NP, Fierro A, Toyama Y, Goult BT, Wang Y, Meng Y, Nishimura R, Fong-Ngern K, Low CSL, Kanchanawong P, Yan J, Ravasio A, and Bertocchi C. Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction. Nat Commun 2024; 15(1):5608. [PMID: 38969637]
- Zhang X, Ruan L, Wang H, Zhu J, Li T, Sun G, Dong Y, Wang Y, Berreby G, Shay A, Chen R, Ramachandran S, Dawson VL, Dawson TM, and Li R. Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity. NPJ Parkinsons Dis 2024; 10(1):120. [PMID: 38906862]
