What are septins?
What is the role of septins in infection? Host (human) septins play a role in bacterial pathogenesis [1] and in host defense mechanisms, mainly, autophagy [2]. Although actin is the most commonly exploited cytoskeletal [...]
How do bacteria modulate the host cytoskeleton?
How do bacteria modulate the host cytoskeleton? Some bacterial pathogens gain entry and subvert immune detection by surviving intracellularly. Others remain extracellular, but manipulate host pathways from outside. A common strategy employed by both [...]
What are actin comet tails?
What are actin comet tails? Actin comet tails are actin structures formed by the dynamic polymerization of actin beneath some species of intracellular bacteria belonging to the genus Listeria, Shigella, Ricketssia, Mycobacterium and Burkholderia. [...]
Mechanobiology of bacterial pathogenesis
Bacterial Pathogenesis Pathogenesis is defined as the origination and development of a disease. Insights into disease etiology and progression, the two major aspects of pathogenesis, are paramount in the prevention, management and treatment of [...]
How does the heart form?
How does the heart form? The heart is derived from the splanchnic lateral mesoderm and initially forms as two crescent-shaped endocardial plates inside the evolving pericardial cavity. As the embryo undergoes lateral and cranial [...]
What are actin pedestals?
What are actin pedestals? Actin pedestals are raised actin structures formed by the dynamic polymerization of host actin, induced by effector proteins secreted by extracellular pathogens like Enteropathogenic Escherichia coli (EPEC) and Enterohaemorrhagic Escherichia [...]
Ding Wei Yung
Alumni
Principal Investigator
Research Interests
Cell-Matrix and Cell-Cell Mechanotransduction, Molecular Mechanisms of Mechanobiology
Wei Yung’s interest lies in understanding the sophistication of cells as robust machines. Using C. elegans, a 1mm nematode, as a model system, he investigates the cellular machinery underlying newly fertilized zygotes that drives critical force-dependent processes such as polarization and cytokinesis.
Biography
Wei Yung completed his Bachelor’s degree in Bioengineering (Second Class Upper) from the National University of Singapore in 2012. In his honors dissertation under the co-supervision of Professor James Goh and Professor Wong Hee Kit, he optimized the conditions required for the construction of interbody spinal fusion device using primary adipose stem cells seeded in a biodegradable polycaprolactone/tricalcium sulphate (PCL/TCP) scaffold. The work was presented in the Bioengineering Showcase 2012 and he was awarded the Best Poster Award. After he was enrolled in the Mechanobiology Graduate Program, he joined Dr. Zaidel-Bar’s Cell Adhesion and Morphogenesis Lab and is currently searching for novel genes involved in regulating C. elegans early embryogenesis.
