How does chromatin remodeling impact gene transcription? While chromosome territory dynamics is believed to regulate gene expression through the redistribution of genes and the subsequent co-localization of these genes with transcription machinery, changes are [...]

How is transcription regulated in stem cells? Pluripotent stem cells can potentially differentiate into any given cell type. They commonly exhibit mechanically softer nuclei [1], lack type-A lamins [2] and have a poorly defined [...]

How is DNA replicated? Cells must replicate their DNA before they can divide. This ensures that each daughter cell gets a copy of the genome, and therefore, successful inheritance of genetic traits. DNA replication [...]

What is translation? Translation is a process that involves the synthesis of an amino acid chain from an mRNA blueprint. These polypeptide chains fold into functional proteins. Translation occurs outside the nucleus once nuclear [...]

What are telomeres? Telomeres are short nucleotide sequences found at the end of linear chromosomes which protect the genetic information. In vertebrates, telomeres have the hexameric sequence TTAGGG. During DNA replication, the double stranded [...]