What is Arf6-associated endocytosis? Arf6-associated endocytosis is a clathrin-independent, plasma membrane-endosomal recycling pathway, regulated by the Arf6 protein, which is a member of the Arf family of small GTPases [1]. In this pathway, Arf6 [...]

What is Rho-dependent IL-2 receptor endocytosis? Internalization of transmembrane receptors was thought to occur exclusively via clathrin-mediated endocytosis (CME). However, the discovery of clathrin-independent endocytic routes, in particular, the pathway that mediates the internalization [...]

What is flotillin-associated endocytosis? Flotillins, which are proteins that localize to specific microdomains or lipid rafts in the plasma membrane, mediate a clathrin-independent endocytosis pathway that is regulated by the Src family tyrosine kinase [...]

What is Fast Endophilin-Mediated Endocytosis (FEME)? FEME is a novel clathrin-independent endocytic pathway, regulated by the BAR domain protein endophilin, where tubulo-vesicular carriers form within seconds at the plasma membrane upon activation of specific [...]

What is autophagy? Autophagy, meaning self-eating, is an intracellular degradation system wherein unwanted cargo, such as old or damaged organelles, unneeded proteins, as well as pathogenic agents, are digested and the macromolecular contents from [...]