What are microtubules? Microtubules are hollow cylinders [1] that are approximately 25nm in diameter [2] and vary in length from 200 nm to 25 μm. They are formed by the lateral association of between [...]

How are intermediate filaments assembled? The soluble subunit for creating intermediate filaments is a tetramer. The tetramer is created from monomers in a stepwise fashion (as reviewed in [1]). First, two monomers associate via [...]

What are intermediate filaments? Intermediate filaments are a primary component of the cytoskeleton, although they are not found in all eukaryotes, and are absent in fungi and plants [1]. These filaments, which extend throughout [...]

I-BAR and Other Proteins/Factors Proteins containing I-BAR (inverted Bin/amphiphysin/Rvs i.e. IRSp53 Missing-in-metastasis homology Domain or IMD) cooperate with various components of actin filament assembly, to promote filopodia protrusion, via several mechanisms including the stimulation [...]

Fimbrin Fimbrin (aka plastin homologue, accumentin) is an actin binding protein that was originally identified in microvilli [1][2]. This schematic diagram illustrates the molecular organization of fimbrin as depicted in this resource, and [...]

Filamin The filamin family of proteins bind to both actin and a number of signaling molecules including Rho GTPases. Evidence for this was shown with the loss of Filamin-A in M2 Melanoma cells, which [...]