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Bridging the (BP)GAP in metastasis

A collaborative study between researchers at MBI and scientists locally and overseas discovered how a scaffolding protein synchronizes, in space and time, two important regulatory proteins driving cell migration

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Recent Featured Research

Shedding Light on Local Microtubule Regulation of Focal Adhesions

By Andrew Wong|Aug 8th, 2025|Categories: Bershadsky Lab, Featured Research, MBInsights, Science Features|

Researchers from the Bershadsky Lab at MBI utilized optogenetics to unlock the role of microtubules in regulating focal adhesion disassembly, an important step in cell migration. http://www.mbi.nus.edu.sg/featured-research/microtubules-and-cell-movement-a-closer-look-at-focal-adhesion-disassembly

MBInsights Annual

MBInsights: Decoding the Living Machine

An annual summary of research at the Mechanobiology Institute, National University of Singapore

The annual is a synopsis showing the breadth of the research coming from the MBI. We are very proud of the fact that we have been able to build an institute with state-of-the-art capabilities in super-resolution microscopy and microfabrication. Our open lab environment and the energy of our students and postdocs have combined to take advantage of our experimental tools to answer important biological questions. Because we believe that these tools should be utilized to solve many more problems in the biomedical sciences, we invite you and your colleagues to join us in collaborative studies to solve those problems. Many different disciplines are needed since the problems need the tools of physicists, biologists, computational scientists, and engineers, working side-by-side to better understand how biological systems integrate mechanical cues and physical forces from the world around them.

Read more about MBInsights Annual 2017
See all editions of MBInsights Annual

Awards and Honors

MBI acknowledges our celebrated principal investigators and researchers.

News and Featured Events

Upcoming events, conferences, outreach and more at MBI.

A Warm Welcome to the 2025 Ph.D Cohort!

MBI is delighted to welcome the 2025 cohort of Ph.D students. Coming from a rich tapestry of countries – China, Vietnam, Singapore, India and the Philippines – these eleven outstanding individuals bring with them interdisciplinary expertise and fresh perspectives that will enrich MBI’s vibrant research community.

By Brenda Lau|Aug 7th, 2025|Categories: News|Comments Off on A Warm Welcome to the 2025 Ph.D Cohort!

Collaborators and Visiting Scientists

Visiting faculty, on-site guests and visitors.

MBI Publications

Latest Publications

  1. Dinh Le T, Tran Y, Gao Y, Valerio VL, Ge Z, and Lim CT. Laser-induced graphene for biomedical applications: innovations in health monitoring and diagnostics. Nanoscale Horiz 2025;. [PMID: 40878095]
  2. Bellamy C, Hajal C, Ligon KL, and Touat M. Revisiting an old therapy for new, promising combinations: biology and perspectives of lomustine in glioma treatment. Neuro Oncol 2025;. [PMID: 40827019]
  3. Tanida S, Fuji K, Lu L, Guyomar T, Lee BH, Honigmann A, Grapin-Botton A, Riveline D, Hiraiwa T, Nonomura M, and Sano M. Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure. PLoS Comput Biol 2025; 21(8):e1012090. [PMID: 40825079]
  4. Venugopal Menon N, Lee J, Truong HD, Bharathkumar S, and Lim CT. Orbital shaker-driven gut-on-a-chip platform for drug-induced permeability and microenvironment studies. Lab Chip 2025;. [PMID: 40824384]
  5. Tomida K, Ong HT, Young JL, and Chan CJ. Capturing ovarian dynamics through spatial profiling of the mechano-microenvironment. Semin Cell Dev Biol 2025; 175:103642. [PMID: 40795409]
  6. Zhang Q, Xu X, Jiang J, Han Z, Ye Y, He J, Chua CY, Wang X, Wang J, Wu B, Li A, Liu S, Wong TLM, and Luo X. Comparison between cap-aspiration lumpectomy versus endoscopic submucosal dissection for the treatment of small gastric submucosal tumors: a prospective randomized controlled trial. Surg Endosc 2025;. [PMID: 40775469]
  7. Li Z, Dai A, Lin S, Zhang R, and Li B. Twist-Induced Networking and Fast Propagation of Defects in Three-Dimensional Active Nematics. Phys Rev Lett 2025; 135(2):028302. [PMID: 40743152]
  8. Wu T, Li X, Gao B, Yagi I, and Lim CT. Structural Design Strategies for Advancing Sensing on Wearable Meta-Microneedle Bandages. ACS Sens 2025;. [PMID: 40667618]
  9. Balasubramaniam L, Monfared S, Ardaševa A, Rosse C, Schoenit A, Dang T, Maric C, Hautefeuille M, Kocgozlu L, Chilupuri R, Dubey S, Marangoni E, L Doss B, Chavrier P, Mège R, Doostmohammadi A, and Ladoux B. Dynamic forces shape the survival fate of eliminated cells. Nat Phys 2025;. [PMID: 40636322]
  10. Mu B, Rutkowski DM, Grenci G, Vavylonis D, and Zhang D. Ca2+-dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion. BMC Biol 2025; 23(1):207. [PMID: 40629316]

All MBI publications

Disrupted Cell-Matrix Interactions Drives Aging and Reveals New Paths for Skin Regeneration

Researchers from the Li Lab discover how α5-integrin–FN interactions preserve dermal integrity, offering new insights for antiaging strategies targeting ECM organization and fibroblast function.

By Brenda Lau|Aug 27th, 2025|Categories: Featured Research, Li Lab, Science Features|Comments Off on Disrupted Cell-Matrix Interactions Drives Aging and Reveals New Paths for Skin Regeneration

The Nano-Heartbuilder: BNIP-2 Influences Mechanosensing in Cardiomyoblast Differentiation

Researchers from the Low Lab at MBI discover a crucial role for the scaffold protein BNIP-2 in orchestrating focal adhesion dynamics during early heart development, offering new insights into heart regeneration strategies.

By Brenda Lau|Aug 12th, 2025|Categories: Featured Research, Low BC Lab, MBInsights, Science Features|Comments Off on The Nano-Heartbuilder: BNIP-2 Influences Mechanosensing in Cardiomyoblast Differentiation

Contributions

MBInsights is created and curated by the MBI Science Communications Unit. The Science Communications Unit works towards enhancing awareness of progress made in the field of mechanobiology to the general public, science enthusiasts, young students and scientists working in alternative fields. This is achieved by promoting the latest findings in our own research, and in the field in general, through the media, the production of online educational resources, and outreach events.

Have a question or comment about MBI’s research? Contact us.

About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
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