CHII JOU (JOE) CHAN LABORATORY

Mammalian Development and Tissue Hydraulics Laboratory

Our research aims to address two broad questions in developmental biology: How are tissue size and shape precisely controlled during early mammalian development? How is tissue geometry sensed and transmitted to the cellular level to impact cellular functions? How are mechanics and biochemical signalling integrated across multiple scales to ensure robust morphogenesis and patterning?

To address these fundamental questions, we focus on understanding mammalian follicle development, which is critical for the maturation of functional eggs for successful reproduction. We aim to identify the mechanobiology principles underlying mammalian follicle growth, and decipher the roles of tissue mechanics and fluid forces in oocyte quality control, using ex vivo mouse ovaries and follicle culture. A quantitative and mechanical understanding of folliculogenesis will deepen our understanding of reproductive biology and ageing, with important implications for assisted reproductive technology (ART), infertility treatment and mechano-therapeutics.