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X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
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DTSTART:20180101T000000
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DTSTART;TZID=Asia/Singapore:20190313T130000
DTEND;TZID=Asia/Singapore:20190313T140000
DTSTAMP:20260422T045857
CREATED:20190307T044014Z
LAST-MODIFIED:20190307T044014Z
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SUMMARY:MBI PhD Qualifying Exam: Mechanotransduction pathways regulating the geometric reprogramming of fibroblasts by Yuan Luezhen
DESCRIPTION:MBI PhD Qualifying Exam\nTime: 1pm\nDate: 13 March 2019\, Wednesday\nVenue: MBI\, Level 5 Meeting Room. \nSupervisor: Dr GV Shivashankar \nMechanotransduction pathways regulating the geometric reprogramming of fibroblasts\nBy Yuan Luezhen\, Shivashankar Lab \nOur laboratory recently discovered that lateral confinement growth induces reprogramming of fibroblasts to embryonic stem cell-like states without exogenous expression of reprogramming factors. This highlights the role of cell geometry in regulating cell state switching. However\, the detailed mechanobiology\, especially how cell geometry could precisely regulate gene expression through altering the activity of transcription factors and controlling epigenetics states is largely unknown. The goal of my Ph.D. project is to elucidate the mechanism of lateral confinement growth induced reprogramming process.  In this presentation\, I will show the rationale of this project along with the preliminary results demonstrating the role of Lef1 and β-catenin in this reprogramming process. My proposed research will have important implications in increasing the efficiency of reprogramming and also contribute towards understanding the role of cell geometry control in cell state switching in disease progression. \n  \n**Please note the examination following the seminar is closed-door** \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-qualifying-exam-mechanotransduction-pathways-regulating-the-geometric-reprogramming-of-fibroblasts-by-yuan-luezhen/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
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