Jay GROVES
Co-Principal Investigator
jtgroves@lbl.gov
+01 510 666 3602
408A Stanley Hall
Berkeley College of Chemistry
Berkeley, CA 94720-1460
Laboratory website
Groves Lab
Research Program
Technology Innovation for Mechanobiology
Affiliations
Professor, Department of Chemistry and Howard Hughes Medical Institute Investigator, University of California, Berkeley, USA
Jay Groves
Co-Principal Investigator
Research Areas
Signal transduction; Cellular biophysics
Research Interests
Dr Groves has had a long-standing interest in the physical and biological aspects of cell membranes. His group combines aspects of cellular biophysics, physical chemistry, and materials science to study key aspects of signal transduction processes in cell membranes.
Biography
Dr Groves received his BS degree in Physics and Chemistry (summa cum laude) from Tufts University in 1992, followed by his Ph.D. in Biophysics from Stanford University in 1998. At Stanford, he worked with Professors Steven Boxer and Harden McConnell, and there developed the patterned supported membrane technology. In 1998 he went to Academia Sinica in Taipei, Taiwan as a Visiting Scholar, and then joined the Lawrence Berkeley National Laboratory as a Division Director’s Fellow in 1999. In 2001 he joined the faculty of the Chemistry Department at UC Berkeley, where he is currently an Associate Professor with tenure. In 2008 he became a Howard Hughes Medical Institute Investigator and in 2009 joined MBI. Dr Groves is best known for his introduction of the Spatial Mutation technology and its application to physical studies of cell biology.
Education
PhD Stanford University
Recent Publications
- Oh D, Chen Z, Biswas KH, Bai F, Ong HT, Sheetz MP, and Groves JT. Competition for shared downstream signaling molecules establishes indirect negative feedback between EGFR and EphA2. Biophys J 2022;. [PMID: 35430415]
- Chen Z, Oh D, Biswas KH, Zaidel-Bar R, and Groves JT. Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility. Elife 2021; 10. [PMID: 34414885]
- Chen Z, Cao Y, Lin C, Alvarez S, Oh D, Yang P, and Groves JT. Nanopore-mediated protein delivery enabling three-color single-molecule tracking in living cells. Proc Natl Acad Sci U S A 2021; 118(5). [PMID: 33495347]
- Alieva NO, Efremov AK, Hu S, Oh D, Chen Z, Natarajan M, Ong HT, Jégou A, Romet-Lemonne G, Groves JT, Sheetz MP, Yan J, and Bershadsky AD. Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion. Nat Commun 2019; 10(1):3593. [PMID: 31399564]
- Huang WYC, Alvarez S, Kondo Y, Lee YK, Chung JK, Lam HYM, Biswas KH, Kuriyan J, and Groves JT. A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS. Science 2019; 363(6431):1098-1103. [PMID: 30846600]
- Dong M, Spelke DP, Lee YK, Chung JK, Yu C, Schaffer DV, and Groves JT. Spatiomechanical Modulation of EphB4-ephrin-B2 Signaling in Neural Stem Cell Differentiation. Biophys. J. 2018;. [PMID: 30075851]
- Biswas KH, Cho N, and Groves JT. Fabrication of Multicomponent, Spatially Segregated DNA and Protein-Functionalized Supported Membrane Microarray. Langmuir 2018;. [PMID: 30032610]
- Chen Z, Oh D, Biswas KH, Yu C, Zaidel-Bar R, and Groves JT. Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29866846]
- Chen Z, Oh D, Dubey AK, Yao M, Yang B, Groves JT, and Sheetz M. EGFR family and Src family kinase interactions: mechanics matters? Curr. Opin. Cell Biol. 2017; 51:97-102. [PMID: 29289897]
- Vafaei S, Tabaei SR, Biswas KH, Groves JT, and Cho N. Dynamic Cellular Interactions with Extracellular Matrix Triggered by Biomechanical Tuning of Low-Rigidity, Supported Lipid Membranes. Adv Healthc Mater 2017;. [PMID: 28371558]