BEGIN:VCALENDAR
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PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Singapore
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:+08
DTSTART:20190101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200402T020000
DTEND;TZID=Asia/Singapore:20200402T150000
DTSTAMP:20260417T213533
CREATED:20200325T074732Z
LAST-MODIFIED:20200413T062443Z
UID:29666-1585792800-1585839600@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Qualifying Exam: Mechanical stability of filamin-mediated connection between cytoskeleton network and membrane receptors
DESCRIPTION:MBI PhD Qualifying Exam\nTime: 2pm\nDate: 2 April 2020\, Thursday\nVenue: T-Lab\, Level 5 Meeting Room \nSupervisor: Prof. Yan Jie \nMECHANICAL STABILITY OF FILAMIN-MEDIATED CONNECTION BETWEEN CYTOSKELETON NETWORK AND MEMBRANE RECEPTORS\nBy: DENG Yunxin\, Yan Jie Group \nAbstract: Mechanosensing of cells involves dynamic assembly of various supramolecular force-transmission linkages\, which allow the cells to properly sense and respond to the level of mechanical force in the linkages. A force-transmission linkage typically consists of a few non-covalently linked proteins\, in which the domains and protein-protein interfaces (PPIs) are subject to dynamic fluctuation of intracellular forces. This results in highly complex force-dependent conformations of the domains and the interactions of these domains with numerous signalling proteins. \nFilamins\, a family of large actin-binding proteins\, play critical roles in mechanosensing of cells. They crosslink actin filaments and mediate molecular linkages between cytoskeleton network and membrane receptors. They are subjected to tensile forces generated from external mechanical perturbation or internal actomyosin contraction. In addition\, they act as a scaffold by interacting with more than 90 cytosolic and membrane proteins. Mutations in filamins are related to a variety of diseases known as “filaminopathies”. \nThe mechanisms underlying the filamin-mediated mechanosensing remain poorly understood\, partly due to a lack of understanding of filamin-mediated force-transmission\, force regulation and interactions. My Ph. D study aims to address this lack of understanding. I propose to examine how force affects the filamins’ conformation\, filamins’ domain structural stability\, filamins’ interactions with binding partners\, and the mechanical stability of filamin-receptor PPIs. The studies will be focused on filamin A (FLNA)\, the major isoform of filamin in cells\, and will be mainly based on single-molecule mechanical manipulation of individual PPIs or domains using magnetic tweezers. The single-molecule studies will be complemented with steered full-atom molecular dynamics simulation and physical modelling. \n  \n**Please note the examination following the seminar is closed-door** \n  \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-qualifying-exam-mechanical-stability-of-filamin-mediated-connection-between-cytoskeleton-network-and-membrane-receptors/
LOCATION:Webcast only
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200407T100000
DTEND;TZID=Asia/Singapore:20200407T103000
DTSTAMP:20260417T213533
CREATED:20200402T074554Z
LAST-MODIFIED:20200413T062355Z
UID:29726-1586253600-1586255400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Ligand-free diffusion kinetics of EGFR and its interaction with focal adhesion complex by Alok Kumar Dubey
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\n\n\nTime: 10.00am – 11.00am\nDate: Tuesday\, 7 April 2020\nVenue: Online seminar via ZOOM \nLigand-free diffusion kinetics of EGFR and its interaction with focal adhesion complex\nBy Alok Kumar Dubey\, PhD Student\, Sheetz Group \n\nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-ligand-free-diffusion-kinetics-of-egfr-and-its-interaction-with-focal-adhesion-complex-by-alok-kumar-dubey-2/
LOCATION:Webcast only
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200407T103000
DTEND;TZID=Asia/Singapore:20200407T110000
DTSTAMP:20260417T213533
CREATED:20200402T074743Z
LAST-MODIFIED:20200413T062310Z
UID:29730-1586255400-1586257200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: MBI Green Initiatives Updates by Christine Lim
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\n\n\nTime: 10.30am – 11.00am\nDate: Tuesday\, 7 April 2020\nVenue: Online seminar via ZOOM \nMBI Green Initiatives Updates\nBy Christine Lim\, Laboratory Executive\, Wet Lab Core \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-mbi-green-initiatives-updates-by-christine-lim/
LOCATION:Webcast only
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200413T020000
DTEND;TZID=Asia/Singapore:20200413T160000
DTSTAMP:20260417T213533
CREATED:20200409T022903Z
LAST-MODIFIED:20200413T062231Z
UID:29740-1586743200-1586793600@www.mbi.nus.edu.sg
SUMMARY:MBI Young Scientist Group Workshop: Basics of Matlab Session 1
DESCRIPTION:MBI Young Scientist Group Workshop: Basics of Matlab\nDate: April 13th/April 20th\, 2020\nTime: 2pm – 4pm\nVenue: Online only\, Zoom session \nThis period of lockdown is a good time to pick up a few skills. With this in mind\, the MBI Graduate Student Club and Postdoc Committees (MBI Young Scientist Group) will be conducting a two day basic Matlab programming workshop\, open to everyone in MBI. There will be two sessions. Session 1 will be an introduction to Matlab basics and how it can be used to present data. Session 2 will be based on your feedback and requests. Please fill this short form to submit your request for session 2: https://forms.gle/zPUjjZvDQqesRvei6 \nDetails of the workshop are as follows: \nWorkshop: Basics of Matlab\nInstructors: Tricia Loo and Sam Barnett \nSession 1\nWhat you’ll learn: Basics and Data presentation using Matlab\nWhen: 13th April 2020 (Mon)\, 2:00-4:00pm \nSession 2\nWhat you’ll learn: TBC (based on user requests)\nWhen: 20th April 2020 (Mon)\, 2:00-4:00pm \nWe recommend everyone download and install Matlab on their computer before the first session. You can find the link to download here: \n\nFor students: https://nusit.nus.edu.sg/services/software_and_os/software/software-student/\nFor staff: https://staffportal.nus.edu.sg/staffportal/it/software/software.html\n\nPlease feel free to contact dasvit.shetty@u.nus.edu if you have any queries or suggestions. \n  \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-young-scientist-group-workshop-basics-of-matlab-session-1/
LOCATION:Webcast only
CATEGORIES:MBI Young Scientists Group
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200414T100000
DTEND;TZID=Asia/Singapore:20200414T110000
DTSTAMP:20260417T213533
CREATED:20200413T022931Z
LAST-MODIFIED:20200413T062129Z
UID:29746-1586858400-1586862000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Yap and Taz are essential in the survival of embryonic epidermal basal cells by Jason Lai
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 14 April 2020\nVenue: Online only \nYap and Taz are essential in the survival of embryonic epidermal basal cells\nBy Jason Lai\, Research Fellow\, Saunders Group \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-yap-and-taz-are-essential-in-the-survival-of-embryonic-epidermal-basal-cells-by-jason-lai/
LOCATION:Webcast only
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200415T100000
DTEND;TZID=Asia/Singapore:20200415T103000
DTSTAMP:20260417T213533
CREATED:20200401T004556Z
LAST-MODIFIED:20200413T062035Z
UID:29719-1586944800-1586946600@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defence: Developing label-free single-molecule assays to enable precise quantification of dynamics in DNA-processing proteins by Lu Chen
DESCRIPTION:MBI PhD Oral Defence\nTime: 10AM\nDate: Wednesday\, 15 April 2020\nVenue: Webcast only \nSupervisor: Prof. Yan Jie \nDEVELOPING LABEL-FREE SINGLE-MOLECULE ASSAYS TO ENABLE PRECISE QUANTIFICATION OF DYNAMICS IN DNA-PROCESSING PROTEINS\nby LU Chen\, Yan Jie Group \nCells rely on a series of complex functions to copy\, utilize\, protect and correct DNA information. Among these processes\, dynamic transitions between double stranded DNA (dsDNA) and single stranded DNA (ssDNA) are frequently regarded as the core components. A class of protein called helicases play the pivotal roles behind these transitions\, for their active engagement in DNA unwinding\, rewinding\, and translocation functions. Studying helicases is therefore not only beneficial for understanding any of the particular functions mentioned\, but also helpful in decoding the complex DNA processes as a whole. Despite the great importance\, the molecular mechanisms of helicase activities remain largely elusive\, and one of the major obstacles is the lack of accurate assays to probe these activities. That is especially apparent for the study of less-elucidated helicase-dependent DNA translocation function. To cater to this problem\, two label-free single-molecule translocation assays were designed\, constructed and validated in parallel based on the our ultra-stable magnetic tweezers. Using these assays\, precise quantification of translocation\, unwinding and re-zipping rates for Saccharomyces cerevisiae Pif1 (ScPif1) and its ΔN mutant were achieved. The comparison of these rates suggested that ScPif1 is a rather active helicase\, while the N-terminal domain may play a crucial role in maintaining that property. In addition\, our assays also helped identify two translocation modes of ScPif1\, one dubbed as mobile translocation and the other involving an unexpected loop-generation activity. It was found that the switch between the dual translocation modes was heavily dependent on the helicase’s concentration. Besides that\, our studies also revealed the same dual translocation modes being evident for another helicase UvrD. Together with the rare rewinding activity discovered on both helicases\, our observations suggested that the properties more common than expected may be shared among helicases\, implying a general molecular mechanism behind. Finally\, experimental designs utilizing the novel translocation assays implemented in this thesis were provided to further test the mechanism\, and hopefully to decipher all the helicase-dependent functions in the near future. \n**Please note the examination following the seminar is closed-door** \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defence-developing-label-free-single-molecule-assays-to-enable-precise-quantification-of-dynamics-in-dna-processing-proteins-by-lu-chen/
LOCATION:Webcast only
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200417T100000
DTEND;TZID=Asia/Singapore:20200417T110000
DTSTAMP:20260417T213533
CREATED:20200416T034320Z
LAST-MODIFIED:20200416T034515Z
UID:29800-1587117600-1587121200@www.mbi.nus.edu.sg
SUMMARY:MBIw: Dynamical ordering of migrating cells by Tetsuya Hiraiwa
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am – 11.00am\nDate: Friday\, 17 April 2020\nVenue: Webcast only \nDynamical ordering of migrating cells\nby Tetsuya Hiraiwa\, MBI Fellow\, Theoretical Physical Biology \n  \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbiw-dynamical-ordering-of-migrating-cells-by-tetsuya-hiraiwa/
LOCATION:Webcast only
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200420T140000
DTEND;TZID=Asia/Singapore:20200420T160000
DTSTAMP:20260417T213533
CREATED:20200409T023342Z
LAST-MODIFIED:20200413T062022Z
UID:29743-1587391200-1587398400@www.mbi.nus.edu.sg
SUMMARY:MBI Young Scientist Group Workshop: Basics of Matlab Session 2
DESCRIPTION:MBI Young Scientist Group Workshop: Basics of Matlab\nDate: April 13th/April 20th\, 2020\nTime: 2pm – 4pm\nVenue: Online only \nThis period of lockdown is a good time to pick up a few skills. With this in mind\, the MBI Graduate Student Club and Postdoc Committees (MBI Young Scientist Group) will be conducting a two day basic Matlab programming workshop\, open to everyone in MBI. There will be two sessions. Session 1 will be an introduction to Matlab basics and how it can be used to present data. Session 2 will be based on your feedback and requests. Please fill this short form to submit your request for session 2: https://forms.gle/zPUjjZvDQqesRvei6 \nDetails of the workshop are as follows: \nWorkshop: Basics of Matlab\nInstructors: Tricia Loo and Sam Barnett \nSession 1\nWhat you’ll learn: Basics and Data presentation using Matlab\nWhen: 13th April 2020 (Mon)\, 2:00-4:00pm \nSession 2\nWhat you’ll learn: TBC (based on user requests)\nWhen: 20th April 2020 (Mon)\, 2:00-4:00pm \nWe recommend everyone download and install Matlab on their computer before the first session. You can find the link to download here: \n\nFor students: https://nusit.nus.edu.sg/services/software_and_os/software/software-student/\nFor staff: https://staffportal.nus.edu.sg/staffportal/it/software/software.html\n\nPlease feel free to contact dasvit.shetty@u.nus.edu if you have any queries or suggestions. \n  \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-young-scientist-group-workshop-basics-of-matlab-session-2/
LOCATION:Webcast only
CATEGORIES:MBI Young Scientists Group,Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200421T100000
DTEND;TZID=Asia/Singapore:20200421T103000
DTSTAMP:20260417T213533
CREATED:20200417T051213Z
LAST-MODIFIED:20200417T051243Z
UID:29802-1587463200-1587465000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Trajectory inference: tracking the heterogeneity in reprogramming induced by laterally confined growth by Saradha Venkatachalapathy
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 21 April 2020\nVenue: Online seminar via ZOOM \nTrajectory inference: tracking the heterogeneity in reprogramming induced by laterally confined growth\nby Saradha Venkatachalapathy\, PhD Student\, Shivashankar Group \n  \nPlease note this event is open to MBI researchers and invited guests only. \n  \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-trajectory-inference-tracking-the-heterogeneity-in-reprogramming-induced-by-laterally-confined-growth-by-saradha-venkatachalapathy/
LOCATION:Webcast only
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200421T103000
DTEND;TZID=Asia/Singapore:20200421T110000
DTSTAMP:20260417T213533
CREATED:20200417T051350Z
LAST-MODIFIED:20200417T051414Z
UID:29805-1587465000-1587466800@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Introduction to new microscope booking system: PPMS by Jasmine Chin\, Microscopy Core
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 21 April 2020\nVenue: Online seminar via ZOOM \nIntroduction to new microscope booking system – PPMS\nby Jasmine Chin\, Microscopy Core\, Mechanobiology Institute (NUS) \n  \nPlease note this event is open to MBI researchers and invited guests only. \n  \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-introduction-to-new-microscope-booking-system-ppms-by-jasmine-chin-microscopy-core/
LOCATION:Webcast only
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200428T100000
DTEND;TZID=Asia/Singapore:20200428T110000
DTSTAMP:20260417T213533
CREATED:20200422T064618Z
LAST-MODIFIED:20200422T064618Z
UID:29808-1588068000-1588071600@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Implementing Optogenetic Modulation in Mechanotransduction by Yu Miao
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 28 April 2020\nVenue: Online seminar via ZOOM \nImplementing Optogenetic Modulation in Mechanotransduction\nBy Yu Miao\, Research Fellow\, Yan Jie Group \n  \n\nPlease note this event is open to MBI researchers and invited guests only. \n  \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-implementing-optogenetic-modulation-in-mechanotransduction-by-yu-miao-2/
LOCATION:Webcast only
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200428T103000
DTEND;TZID=Asia/Singapore:20200428T110000
DTSTAMP:20260417T213533
CREATED:20200422T064734Z
LAST-MODIFIED:20200422T064734Z
UID:29810-1588069800-1588071600@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Mechanical function of macrophages in apoptotic cell extrusion by Teng Xiang
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 28 April 2020\nVenue: Online seminar via ZOOM \nMechanical function of macrophages in apoptotic cell extrusion\nBy Teng Xiang\, Research Associate\, Toyama Group \n\nPlease note this event is open to MBI researchers and invited guests only. \n  \nThis event is online only\nDuring the current situation regarding the COVID-19 virus\, MBI seminars will only be available online. Please consult previously distributed information for access information and help. Remember it is important not to share or post meeting information including URLs\, IDs and/or passwords. \nAddress your questions/concerns to the MBI ITCore at mbit@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-mechanical-function-of-macrophages-in-apoptotic-cell-extrusion-by-teng-xiang/
LOCATION:Webcast only
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
END:VCALENDAR