BEGIN:VCALENDAR
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PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Singapore
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:+08
DTSTART:20190101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200106T160000
DTEND;TZID=Asia/Singapore:20200106T170000
DTSTAMP:20260417T110801
CREATED:20191230T041103Z
LAST-MODIFIED:20191230T041103Z
UID:28360-1578326400-1578330000@www.mbi.nus.edu.sg
SUMMARY:Spy and Snoop superglues help to pull\, bridge and build by Mark Howarth
DESCRIPTION:We are pleased to inform you on the seminar by Prof Mark Howarth\, hosted by Prof Yan Jie “Spy and Snoop superglues help to pull\, bridge and build” on 6 Jan 2020 (Mon) @4pm at T-Lab Level 5 Seminar Rooms. \n 
URL:https://www.mbi.nus.edu.sg/event/spy-and-snoop-superglues-help-to-pull-bridge-and-build-by-mark-howarth/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200113T110000
DTEND;TZID=Asia/Singapore:20200113T120000
DTSTAMP:20260417T110801
CREATED:20200106T010900Z
LAST-MODIFIED:20200106T010900Z
UID:28368-1578913200-1578916800@www.mbi.nus.edu.sg
SUMMARY:Mechanochemical feedback control in early mammalian development by Chii Jou Chan
DESCRIPTION:We are pleased to inform you on the seminar of Dr Chii Jou Chan (MBI Faculty Candidate)\, “Mechanochemical feedback control in early mammalian development” on Monday 13 Jan 2020\, 11am\, Dept of Mechanical Engineering E3-06-01.
URL:https://www.mbi.nus.edu.sg/event/mechanochemical-feedback-control-in-early-mammalian-development-by-chii-jou-chan/
LOCATION:E3-06-01
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200113T160000
DTEND;TZID=Asia/Singapore:20200113T170000
DTSTAMP:20260417T110801
CREATED:20200106T010522Z
LAST-MODIFIED:20200106T010522Z
UID:28365-1578931200-1578934800@www.mbi.nus.edu.sg
SUMMARY:Self-organized Tissue Folding Induced by Cell Mechano-polarity Feedback by Wen Fu-lai
DESCRIPTION:We are pleased to inform you on the seminar by Dr Wen Fu-lai\, hosted by Dr Tetsuya Hiraiwa “Self-organized Tissue Folding Induced by Cell Mechano-polarity Feedback” on 13 Jan@4pm at T-Lab Level 5 Meeting Room 1.
URL:https://www.mbi.nus.edu.sg/event/self-organized-tissue-folding-induced-by-cell-mechano-polarity-feedback-by-wen-fu-lai/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200114T100000
DTEND;TZID=Asia/Singapore:20200114T103000
DTSTAMP:20260417T110801
CREATED:20200109T093811Z
LAST-MODIFIED:20200109T093811Z
UID:28464-1578996000-1578997800@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Loss of mechano-sensing in ovarian cancer by Chloe May Simpson
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 14 January 2020\nVenue: Level 5 Meeting Room 1\, T-Lab \nLoss of mechano-sensing in ovarian cancer\nBy Chloe May Simpson\, Research Fellow\, Sheetz Lab \n  \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-loss-of-mechano-sensing-in-ovarian-cancer-by-chloe-may-simpson/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200114T103000
DTEND;TZID=Asia/Singapore:20200114T110000
DTSTAMP:20260417T110801
CREATED:20200109T094041Z
LAST-MODIFIED:20200109T094041Z
UID:28467-1578997800-1578999600@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Interplay Between Microtubules And Integrin-mediated Adhesion In Angiogenesis by Aaron Joseph Farrugia
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 14 January 2020\nVenue: Level 5 Meeting Room 1\, T-Lab \nInterplay Between Microtubules And Integrin-mediated Adhesion In Angiogenesis\nBy Aaron Joseph Farrugia\, Research Fellow\, Bershadsky Lab \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-interplay-between-microtubules-and-integrin-mediated-adhesion-in-angiogenesis-by-aaron-joseph-farrugia/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200120T120000
DTEND;TZID=Asia/Singapore:20200120T130000
DTSTAMP:20260417T110801
CREATED:20200107T065829Z
LAST-MODIFIED:20200107T065829Z
UID:28430-1579521600-1579525200@www.mbi.nus.edu.sg
SUMMARY:Deciphering the dynamic regulations of the precise cell matching by Zhang Shaobo
DESCRIPTION:MBI PhD Oral Defence\nTime: 12PM\nDate: Monday\, 20 January 2020\nVenue: T-Lab Building\, Level 5 Meeting Room 1 \nSupervisor: Prof. Timothy SAUNDERS \nDECIPHERING THE DYNAMIC REGULATIONS OF THE PRECISE CELL MATCHING\nby ZHANG Shaobo\, Saunders Group \nIt has been an age-old question about the embryo development: how the cells find their partners correctly in a complicated as well as dynamic cellular environment? In the past\, studies from neurogenesis have found various molecules being important in this cell matching process. However\, the underlying mechanisms\, especially the dynamics\, remain elusive. Here\, we explored this by applying the cardiogenesis in the Drosophila embryo as a simplified matching system. The formation of the Drosophila heart involves a long range of cell migration but results in robustly formed cell-partner connections. By fast in vivo live imaging\, we found that cell matching is particularly robust at boundaries between cardioblast (CB) subtypes of which their filopodia show distinct binding affinities. Through genetic screening\, we identified the adhesion molecules Fas3 and Ten-m\, both of which also regulate synaptic targeting\, as having complementary expression patterns in CBs. Altering Fas3 or Ten-m expression changes differential filopodia adhesion and leads to CB mismatch. Further\, focusing on Myosin II\, showing ‘wave’ like dynamics within the CBs\, we found that coordination between Myosin II oscillations within CBs and differential filopodia connectivity between CBs is essential in ensuring robust cell matching. By using genetic manipulations and laser ablation\, we have found that the CB filopodia activity is highly Myosin II dependent. It appears that the Myosin II oscillation acts as a “mechanical proof-reader” of cell-cell connections\, whereby weak connections are broken and strong ones reinforced. Altering Myosin II activity – either by over-activation or inhibition of Myosin II – results in perturbed cell matching. Additionally\, changing the Myosin II oscillation pattern also leads to misaligned CBs. Combined\, these results suggest that the mechanical properties of cells are precisely tuned to provide a ‘proofreading’ machinery to ensure robust cell matching. \n\n**Please note the examination following the seminar is closed-door**
URL:https://www.mbi.nus.edu.sg/event/deciphering-the-dynamic-regulations-of-the-precise-cell-matching-by-zhang-shaobo/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200121T100000
DTEND;TZID=Asia/Singapore:20200121T103000
DTSTAMP:20260417T110801
CREATED:20200115T014621Z
LAST-MODIFIED:20200115T014621Z
UID:28487-1579600800-1579602600@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Investigating the Characteristic Saddle Point during Zebrafish Gastrulation by Zhong Jun
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 21 January 2020\nVenue: Level 5 Meeting Room 1\, T-Lab \nInvestigating the Characteristic Saddle Point during Zebrafish Gastrulation.\nBy Zhong Jun\, PhD Student\, Matsudaira Group \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-investigating-the-characteristic-saddle-point-during-zebrafish-gastrulation-by-zhong-jun/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200121T103000
DTEND;TZID=Asia/Singapore:20200121T110000
DTSTAMP:20260417T110801
CREATED:20200115T014752Z
LAST-MODIFIED:20200115T014752Z
UID:28489-1579602600-1579604400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: A short introduction to the uFab core services by Dr. Gianluca Grenci
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 21 January 2020\nVenue: Level 5 Meeting Room 1\, T-Lab \nA short introduction to the uFab core services.\nBy Dr. Gianluca Grenci\, Head of micro-fabrication core facility at Mechanobiology Institute (MBI) NUS and Research Assistant Professor at Biomedical Engineering Department NUS \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-a-short-introduction-to-the-ufab-core-services-by-dr-gianluca-grenci/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200123T110000
DTEND;TZID=Asia/Singapore:20200123T120000
DTSTAMP:20260417T110801
CREATED:20200107T065415Z
LAST-MODIFIED:20200107T065415Z
UID:28427-1579777200-1579780800@www.mbi.nus.edu.sg
SUMMARY:Active Dynamics Of Chromosomal Loci Driven By Enzymatic Force Dipole by Takahiro Sakaue
DESCRIPTION:We are pleased to inform you on the seminar by A/Prof Takahiro Sakaue\, hosted by Dr Tetsuya Hiraiwa “Active Dynamics Of Chromosomal Loci Driven By Enzymatic Force Dipole” on 23 Jan @11am at T-Lab Level 5 Meeting Room 1.
URL:https://www.mbi.nus.edu.sg/event/active-dynamics-of-chromosomal-loci-driven-by-enzymatic-force-dipole-by-takahiro-sakaue/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200124T100000
DTEND;TZID=Asia/Singapore:20200124T110000
DTSTAMP:20260417T110801
CREATED:20200120T045037Z
LAST-MODIFIED:20200120T045037Z
UID:28496-1579860000-1579863600@www.mbi.nus.edu.sg
SUMMARY:MBIw: On growth and form of plant cells and tissues by Henrik Jönsson
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am – 11.00am\nDate: Friday\, 24 January 2020\nVenue: Level 5 Meeting Room 1\, T-Lab \nOn growth and form of plant cells and tissues\nBy Professor Henrik Jönsson\, Associate Director\, University of Cambridge\, UK (hosted by Dr. Timothy Saunders) \nPlant cell growth is assumed to be a turgor driven process where the rigid cell walls yield and expand irreversibly. Since there is no cell migration\, cell and tissue morphogenesis depends on regulation of the mechanics of the cell walls both heterogeneously and anisotropically. I will discuss how different shapes are formed in plants using models where anisotropy in mechanical stress and strain influences material anisotropy and heterogeneity in molecular concentrations influences material heterogeneity. I will further show how this relate to data on plant hormones and cytoskeletal dynamics.
URL:https://www.mbi.nus.edu.sg/event/mbiw-on-growth-and-form-of-plant-cells-and-tissues-by-henrik-jonsson/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200128T100000
DTEND;TZID=Asia/Singapore:20200128T103000
DTSTAMP:20260417T110801
CREATED:20200124T015211Z
LAST-MODIFIED:20200124T015211Z
UID:28527-1580205600-1580207400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Competition between receptor tyrosine kinases for shared downstream signaling pathway: single cell & single molecule studies by Oh Dongmyung
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 28 January 2020\nVenue: Level 5 Meeting Room 1\, T-Lab \nCompetition between receptor tyrosine kinases for shared downstream signaling pathway: single cell & single molecule studies.\nBy Oh Dongmyung\, Research Fellow\, Sheetz Group \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-competition-between-receptor-tyrosine-kinases-for-shared-downstream-signaling-pathway-single-cell-single-molecule-studies-by-oh-dongmyung/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200128T103000
DTEND;TZID=Asia/Singapore:20200128T110000
DTSTAMP:20260417T110801
CREATED:20200124T015320Z
LAST-MODIFIED:20200413T082332Z
UID:28529-1580207400-1580209200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: New Computational Systems and Services at MBI by Kyaw Tun
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 28 January 2020\nVenue: Level 5 Meeting Room 1\, T-Lab \n  \nNew Computational Systems and Services at MBI\nBy Kyaw Tun\, Web Application Design and Development\, MBI \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-new-computational-systems-and-services-at-mbi-by-kyaw-tun/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200129T040000
DTEND;TZID=Asia/Singapore:20200129T170000
DTSTAMP:20260417T110801
CREATED:20200120T052454Z
LAST-MODIFIED:20200120T071421Z
UID:28498-1580270400-1580317200@www.mbi.nus.edu.sg
SUMMARY:MBI Graduate Student Career Talk: Flora Teoh & Jonathan Lee on Science Communication
DESCRIPTION:MBI Graduate Student Committee Career Talk\nTime: 4pm – 5pm\nDate: 29 January 2020\nVenue: Level 5 Meeting Room 1\, T-Lab \n  \nDr. Flora Teoh is a Science Editor at Science Feedback. She completed her PhD and postdoctoral research in Microbiology and Immunology at the Agency for Science\, Technology and Research (A*STAR)\, Singapore. Dr. Flora now works to debunk health myths by examining health-related claims in influential online media \nDr Jonathan Lee is a Senior Medical Editor at McCann Health. After his PhD in regenerative medicine and matrix and stem cell biology at the National University of Singapore (NUS)\, Dr. Jonathan transitioned to medical writing and currently works in the field of health communication and consulting.
URL:https://www.mbi.nus.edu.sg/event/mbi-graduate-student-career-talk-flora-teoh-jonathan-lee-on-science-communication/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Graduate Student Club,MBI Graduate Student Committee,MBI Young Scientists Group
ATTACH;FMTTYPE=image/png:https://www.mbi.nus.edu.sg/wp-content/uploads/2020/01/2020-01-MBI-Graduate-Student-Club-career-talk.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20200129T090000
DTEND;TZID=Asia/Singapore:20200129T100000
DTSTAMP:20260417T110801
CREATED:20200121T013459Z
LAST-MODIFIED:20200121T013459Z
UID:28516-1580288400-1580292000@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense: Investigating the mechanisms governing the initiation and expansion of bile canaliculi by Zhang Yue
DESCRIPTION:MBI PhD Oral Defence\nTime: 9AM\nDate: Wednesday\, 29 January 2020\nVenue: T-Lab Building\, Level 5 Meeting Room 1 \nSupervisor: Prof. Viasnoff Virgile \nINVESTIGATING THE MECHANISMS GOVERNING THE INITIATION AND EXPANSION OF BILE CANALICULI \nby ZHANG Yue\, Viasnoff Group \nBile canaliculi (BC)\, the secretory lumen enclosed by the apical domain of two adjacent polarized hepatocytes\, are the structure basis for various liver function. Abnormalities in the establishment and maintenance of BC structure have been associated with diseases such as cholestasis and liver cancer. As other epithelial tubes found in kidney and lung\, BC are generated through a process termed de novo lumenogenesis\, by which the participating unpolarized hepatocytes acquire apical basal polarity and form bile acid filled apical lumen. However\, how individual hepatocyte initiates apical-basal polarity in response to external cues remain poorly understood. \nIn this thesis\, a 3D single hepatocyte culture system was created to precisely control the biochemical and physical properties of external cues presented to each cell. I found that individual hepatocyte developed fully functional luminal domain when cultured with access to spatially segmented cadherin and ECM signaling. Combined with data from co-culture assay\, I demonstrated that cell polarity is largely a cell autonomous process\, independent of the nature of neighboring cells and the polarity state of triggering signaling. Mechanistically\, actin cortex rearrangements regulated by the biophysical properties and density of cadherins at the initial cell-cell junction is critical for the correct localization of polarity markers. Moreover\, the creation of this single cell model provides unprecedented imaging resolution to observe the development of apical pole at the early stages of lumenogenesis process. Altogether\, the reductionist approach demonstrated that single hepatocyte can be fooled into a functional polarized state by fine-tuning artificial microniches. \n  \n**Please note the examination following the seminar is closed-door**
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-investigating-the-mechanisms-governing-the-initiation-and-expansion-of-bile-canaliculi-by-zhang-yue/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
END:VCALENDAR