BEGIN:VCALENDAR
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PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN
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METHOD:PUBLISH
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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BEGIN:VTIMEZONE
TZID:Asia/Singapore
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:+08
DTSTART:20180101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191203T100000
DTEND;TZID=Asia/Singapore:20191203T103000
DTSTAMP:20260410T160328
CREATED:20191202T010300Z
LAST-MODIFIED:20191202T010300Z
UID:27909-1575367200-1575369000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Structural-elastic Determination of the Lifetime of Biomolecules under Force by Guo Shiwen
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 3 December 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nStructural-elastic Determination of the Lifetime of Biomolecules under Force\nBy Guo Shiwen\, PhD Student\, Yan Jie Group \n  \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-structural-elastic-determination-of-the-lifetime-of-biomolecules-under-force-by-guo-shiwen/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191203T103000
DTEND;TZID=Asia/Singapore:20191203T110000
DTSTAMP:20260410T160328
CREATED:20191202T010357Z
LAST-MODIFIED:20191202T010357Z
UID:27911-1575369000-1575370800@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Practical Deep Learning in MBI by Murat Shagirov
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 3 December 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nPractical Deep Learning in MBI\nBy Murat Shagirov\, PhD Student\, Toyama Group \nIn this talk I will start by introducing deep learning basics\, and then present some of the recent deep learning approaches such as image de-noising\, and restoration applied to microscopy images. \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-practical-deep-learning-in-mbi-by-murat-shagirov/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191206T100000
DTEND;TZID=Asia/Singapore:20191206T110000
DTSTAMP:20260410T160328
CREATED:20191202T060540Z
LAST-MODIFIED:20191202T060540Z
UID:27915-1575626400-1575630000@www.mbi.nus.edu.sg
SUMMARY:MBIw: Single Molecule Force Spectroscopy Reveals the Mechanical Design Governing the Efficient Translocation of the Bacterial Toxin Protein RTX by Prof Hongbin Li
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am -11.00am\nDate: Friday\, 6 Dec 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nSingle Molecule Force Spectroscopy Reveals the Mechanical Design Governing the Efficient Translocation of the Bacterial Toxin Protein RTX\nBy Prof Hongbin Li\, Department of Chemistry\, University of British Columbia\, Vancouver\, BC V6T 1Z1\, Canada (hosted by Prof. Yan Jie ) \n  \nThe efficient translocation of bacterial toxin adenylate cyclase toxin (CyaA) from the bacterial cytosol to the extracellular environment by the type 1 secretion system (T1SS) is essential for the toxin to function. To understand the molecular features that are responsible for the efficient translocation of CyaA\, here we used optical tweezers to investigate the mechanical properties and conformational dynamics of the RTX domain of CyaA at the single molecule level. Our results revealed that apo-RTX behaves like an ideal random coil. This property allows the T1SS to translocate RTX without overcoming enthalpic resistance. In contrast\, the folded holo-RTX is mechancially stable\, and its folding occurs in a vectorial\, co-translocational fashion starting from its C-terminus. Moreover\, our results showed that the folding of holo-RTX generates a stretching force\, i.e. power stroke\, which can further facilitate the translocation of RTX. Our results suggest a quasi-power-stroke mechanism for the translocation of RTX and provide mechanistic insights into the mechanical design that governs the efficient translocation of RTX.
URL:https://www.mbi.nus.edu.sg/event/mbiw-single-molecule-force-spectroscopy-reveals-the-mechanical-design-governing-the-efficient-translocation-of-the-bacterial-toxin-protein-rtx-by-prof-hongbin-li/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191210T140000
DTEND;TZID=Asia/Singapore:20191210T153000
DTSTAMP:20260410T160328
CREATED:20191209T024417Z
LAST-MODIFIED:20191209T024417Z
UID:28078-1575986400-1575991800@www.mbi.nus.edu.sg
SUMMARY:MBI Outreach: Conference Participants from "International Conference on Biomedical Engineering"
DESCRIPTION:There will be a MBI Outreach in collaboration with International Conference on Biomedical Engineering (ICBME)\, where conference participants will be visiting some of MBI’s facilities and lab demonstrations with details as follows: \nDate: 10th Dec\, Tuesday\nProgramme: 2.00pm – 3.30pm\nLab Demonstration: 2.15pm – 3.30pm \nMechanobiology\, Microfluidics\, Wearable Technologies by Prof. CT Lim at L8\, MechanoBioEngineering Lab \nMicrofabrication by Mona and Sree (Dr. Gianluca’s team) at L9\, uFab core wet bench \nNSTORM Superresolution System by Mak Kah Jun and Bi Feng at L9\, microscopy room 7 \nTherefore\, we would like to request your kind cooperation to plan your research discussions/experiments with the above in mind to allow for the smooth running of the outreach.
URL:https://www.mbi.nus.edu.sg/event/mbi-outreach-conference-participants-from-international-conference-on-biomedical-engineering/
LOCATION:National University of Singapore
CATEGORIES:Outreach Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191210T160000
DTEND;TZID=Asia/Singapore:20191210T170000
DTSTAMP:20260410T160328
CREATED:20191203T011741Z
LAST-MODIFIED:20191203T011741Z
UID:27920-1575993600-1575997200@www.mbi.nus.edu.sg
SUMMARY:Mechanically modulated microniches for augmented therapy and disease modeling by Yanan Du
DESCRIPTION:MBI Seminar\nWe are pleased to inform you on the seminar by Prof. Yanan Du\, hosted by Prof Hanry Yu “Mechanically modulated microniches for augmented therapy and disease modeling “on 10 Dec @ 4pm at T-Lab Level 5 Meeting Room 1. Thank you.
URL:https://www.mbi.nus.edu.sg/event/mechanically-modulated-microniches-for-augmented-therapy-and-disease-modeling-by-yanan-du/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191212T173000
DTEND;TZID=Asia/Singapore:20191212T203000
DTSTAMP:20260410T160328
CREATED:20191203T011533Z
LAST-MODIFIED:20191212T033038Z
UID:27917-1576171800-1576182600@www.mbi.nus.edu.sg
SUMMARY:MBI Postdoc & Graduate Student Committee: MBI Christmas Party
DESCRIPTION:The MBI Postdoc and Graduate Student Committee bring you…\nThis year’s MBI Christmas Party! \nWhen: December 12\, 2019 (Thursday)\, 5:30-8:30 PM\nWhere: T-lab\, level 10 foyer \n  \nThis event is limited to MBI personnel only\, thank you.
URL:https://www.mbi.nus.edu.sg/event/mbi-postdoc-graduate-student-committee-mbi-christmas-party/
LOCATION:MBI Level 10 Lobby\, 5A Engineering Drive 1\, Singapore\, 117411\, Singapore
ATTACH;FMTTYPE=image/png:https://www.mbi.nus.edu.sg/wp-content/uploads/2019/12/2019-MBI-gradStudCom-xmas.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191213T100000
DTEND;TZID=Asia/Singapore:20191213T110000
DTSTAMP:20260410T160328
CREATED:20191210T051315Z
LAST-MODIFIED:20191210T051315Z
UID:28111-1576231200-1576234800@www.mbi.nus.edu.sg
SUMMARY:MBIw: Collective and Individual Migration after the Epithelial-Mesenchymal Transition by Ian Y. Wong
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am -11.00am\nDate: Friday\, 13 Dec 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nCollective and Individual Migration after the Epithelial-Mesenchymal Transition\nBy Prof. Ian Y. Wong\, Assistant Professor\, Brown University (hosted by Prof. Lim Chwee Teck) \nCollective behaviors emerge from coordinated cell–cell interactions during the morphogenesis of tissues and tumors. For instance\, cells may display density-dependent phase transitions from a fluid-like “unjammed” phase to a solid-like “jammed” phase\, while different cell types can “self-sort”. We use comprehensive single cell tracking to elucidate these spatially and temporally heterogeneous behaviors in the context of self-organizing patterns. First\, we consider co-cultured mixtures of sheet-forming epithelial cells and dispersed mesenchymal cells\, which show a composition-dependent “unjamming” transition. Second\, we consider a gelation-like mechanism whereby cells at very sub confluent densities organize into spanning network architectures. Finally\, we analyze the disorganization and dissemination of cells cultured in 3D matrix\, which exhibit both collective and individual invasion phenotypes with distinct topological and traction signatures. These complex behaviors exhibit striking analogies with non-living systems\, suggesting that these physical concepts may be applicable to understand development and disease.
URL:https://www.mbi.nus.edu.sg/event/mbiw-collective-and-individual-migration-after-the-epithelial-mesenchymal-transition-by-ian-y-wong/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191223T160000
DTEND;TZID=Asia/Singapore:20191223T170000
DTSTAMP:20260410T160328
CREATED:20191218T034930Z
LAST-MODIFIED:20191218T034930Z
UID:28299-1577116800-1577120400@www.mbi.nus.edu.sg
SUMMARY:Entropy Driven Separation Of Inert Solvent Mixtures Using A Porous Material by Tetsuya Hiraiwa
DESCRIPTION:We are pleased to inform you on the seminar by A/Prof Ryo Akiyama\, hosted by Dr Tetsuya Hiraiwa “Entropy Driven Separation Of Inert Solvent Mixtures Using A Porous Material” on 23 Dec@4pm at T-Lab Level 5 Meeting Room 1. 
URL:https://www.mbi.nus.edu.sg/event/entropy-driven-separation-of-inert-solvent-mixtures-using-a-porous-material-by-tetsuya-hiraiwa/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191227T100000
DTEND;TZID=Asia/Singapore:20191227T110000
DTSTAMP:20260410T160328
CREATED:20191223T052437Z
LAST-MODIFIED:20191223T052437Z
UID:28303-1577440800-1577444400@www.mbi.nus.edu.sg
SUMMARY:MBIw: Potential Application of Mechanobiology in Cancer Diagnosis by Jian Yu Rao
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am -11.00am\nDate: Friday\, 27 Dec 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nPotential Application of Mechanobiology in Cancer Diagnosis\nBy Prof. Jian Yu Rao\,  Professor\, University of California\, Los Angeles\, USA (hosted by Prof. Lim Chwee Teck) \n 
URL:https://www.mbi.nus.edu.sg/event/mbiw-potential-application-of-mechanobiology-in-cancer-diagnosis-by-jian-yu-rao/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
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