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X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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TZID:Asia/Singapore
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191101T100000
DTEND;TZID=Asia/Singapore:20191101T110000
DTSTAMP:20260410T124106
CREATED:20191031T034223Z
LAST-MODIFIED:20191031T034223Z
UID:27783-1572602400-1572606000@www.mbi.nus.edu.sg
SUMMARY:MBIw: OrBID (OculaR BIomaterials and Device): A Biomaterials (polymer) platform providing clinical solutions for retinal disease by Dr Su Xinyi
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am -11.00am\nDate: Friday\, 1 Nov 2019\nVenue: Level 5 Seminar Room\, T-Lab \nOrBID (OculaR BIomaterials and Device): A Biomaterials (polymer) platform providing clinical solutions for retinal disease\nBy Dr Su Xinyi\, Institute of Molecular and Cell Biology\, A*STAR Singapore (hosted by A/Prof. Toyama Yusuke) \nOur research program aims to develop a hydrogel-based biomaterials platform to solve unmet clinical needs in ophthalmology. Our focus is on developing polymers for vitreo-retinal applications\, such as (i)  Vitreous substitutes: as internal tamponade agents after vitrectomy\, (ii) Sustained intravitreal drug delivery\, (iii) Retinal cellular therapeutics: surgical adjuncts for subretinal RPE transplantation. \nCurrent agents used for medium and long-term tamponade after vitreo-retinal surgery\, such as expansile gases and silicone oil\, have been around since the 1960s. Despite their inherent limitations\, they have not been replaced due to a lack of better alternatives. Sustained intravitreal drug delivery of biologics is the holy grail of ocular therapeutics. However\, a suitable drug delivery vehicle has remained elusive due to the lack of ideal biomaterials. Lastly\, stem cell transplantation is seen as the future of retinal therapeutics for treatment of age-related macular degeneration.  There is still a lack of suitable materials to generate multi-layer retinal tissues for functional transplantation. \nWe propose that hydrogels (hydrophilic polymers)\, which are optically clear and strongly resemble the natural vitreous\, are promising alternatives to existing materials. In collaboration with Dr Loh Xian Jun’s group at IMRE\, our team has the ability to synthesize a wide range of proprietary functional\, biodegradable and thermosensitive hydrogels. Of significance\, we have recently demonstrated that our thermogel is able function effectively as an internal tamponade using a non-human primate retinal detachment surgery model\, with no long-term toxicity to the retina. Our future work also includes studying how these hydrogel-based polymers affect retina intra-cellular functions\, and modulate cell-cell interaction.
URL:https://www.mbi.nus.edu.sg/event/mbiw-orbid-ocular-biomaterials-and-device-a-biomaterials-polymer-platform-providing-clinical-solutions-for-retinal-disease-by-dr-su-xinyi/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191105T100000
DTEND;TZID=Asia/Singapore:20191105T103000
DTSTAMP:20260410T124106
CREATED:20191104T022503Z
LAST-MODIFIED:20191104T022737Z
UID:27819-1572948000-1572949800@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Mechanical impact of apoptotic cell extrusion on neighbouring cells by Yow Ying Ming Ivan
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 10.30am\nDate: Tuesday\, 5 November 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nMechanical impact of apoptotic cell extrusion on neighbouring cells\nBy Yow Ying Ming Ivan\, PhD Student\, Toyama Group \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-mechanical-impact-of-apoptotic-cell-extrusion-on-neighbouring-cells-by-yow-ying-ming-ivan/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191105T103000
DTEND;TZID=Asia/Singapore:20191105T110000
DTSTAMP:20260410T124106
CREATED:20191104T022711Z
LAST-MODIFIED:20191104T022711Z
UID:27821-1572949800-1572951600@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Protein Expression Core Introduction by Chen Hongying
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 5 November 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nProtein Expression Core Introduction\nBy Chen Hongying\, Protein Cloning Core \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-protein-expression-core-introduction-by-chen-hongying/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191106T100000
DTEND;TZID=Asia/Singapore:20191106T110000
DTSTAMP:20260410T124106
CREATED:20191101T074733Z
LAST-MODIFIED:20191101T075154Z
UID:27810-1573034400-1573038000@www.mbi.nus.edu.sg
SUMMARY:Spatial-Temporal Regulations in Human Developmental Hematopoiesis by Rio Sugimura 
DESCRIPTION:We are pleased to inform you on the seminar of Dr Rio Sugimura (MBI Faculty Candidate)\, hosted by A/Prof Toyama Yusuke\, “Spatial-Temporal Regulations in Human Developmental Hematopoiesis” on Wednesday 6 Nov 2019 @ 10am at BME (Block E3-06-05).
URL:https://www.mbi.nus.edu.sg/event/spatial-temporal-regulations-in-human-developmental-hematopoiesis-by-rio-sugimura/
LOCATION:National University of Singapore
CATEGORIES:BME Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191107T110000
DTEND;TZID=Asia/Singapore:20191107T120000
DTSTAMP:20260410T124106
CREATED:20191101T074952Z
LAST-MODIFIED:20191101T074952Z
UID:27814-1573124400-1573128000@www.mbi.nus.edu.sg
SUMMARY:Spatial-Temporal Regulations in Human Developmental Hematopoiesis by Rio Sugimura
DESCRIPTION:We are pleased to inform you on the 2nd seminar of Dr Rio Sugimura (MBI Faculty Candidate)\, hosted by A/Prof Tony Kanchanwong\, “Spatial-Temporal Regulations in Human Developmental Hematopoiesis” on Thursday 7 Nov 2019 @ 11am at DBS Conference Room 1.
URL:https://www.mbi.nus.edu.sg/event/spatial-temporal-regulations-in-human-developmental-hematopoiesis-by-rio-sugimura-2/
LOCATION:DBS Conference Room 1\, 14 Science Drive 4\, Singapore\, 117543\, Singapore
CATEGORIES:DBS Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191112T100000
DTEND;TZID=Asia/Singapore:20191112T103000
DTSTAMP:20260410T124106
CREATED:20191107T011917Z
LAST-MODIFIED:20191107T011917Z
UID:27835-1573552800-1573554600@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Rejuvenating aged human cells by mechanical cue-induced reprogramming by Lee Yaelim
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 12 November 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nRejuvenating aged human cells by mechanical cue-induced reprogramming\nBy Lee Yaelim\, Research Fellow\, Shivashankar Group \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-rejuvenating-aged-human-cells-by-mechanical-cue-induced-reprogramming-by-lee-yaelim/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191112T103000
DTEND;TZID=Asia/Singapore:20191112T110000
DTSTAMP:20260410T124106
CREATED:20191107T012008Z
LAST-MODIFIED:20191107T012020Z
UID:27837-1573554600-1573556400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: A short introduction to beginning the academic job hunt by Virgile Viasnoff
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 12 November 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \n  \nA short introduction to beginning the academic job hunt\nBy Virgile Viasnoff\, Associate Professor\, Mechanobiology Institute \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-a-short-introduction-to-beginning-the-academic-job-hunt-by-virgile-viasnoff/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191114T110000
DTEND;TZID=Asia/Singapore:20191114T120000
DTSTAMP:20260410T124106
CREATED:20191114T012030Z
LAST-MODIFIED:20191114T012058Z
UID:27859-1573729200-1573732800@www.mbi.nus.edu.sg
SUMMARY:Observing Single Membrane Proteins Under High Mechanical Tension by Yoon Tae-Young
DESCRIPTION:We are pleased to inform you on the seminar by A/Prof Yoon Tae-Young\, hosted by Prof Yan Jie “Observing Single Membrane Proteins Under High Mechanical Tension” on 14 Nov @ 11am at T-Lab Level 5 Seminar
URL:https://www.mbi.nus.edu.sg/event/observing-single-membrane-proteins-under-high-mechanical-tension-by-yoon-tae-young/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191114T150000
DTEND;TZID=Asia/Singapore:20191114T160000
DTSTAMP:20260410T124106
CREATED:20191031T052754Z
LAST-MODIFIED:20191031T052906Z
UID:27785-1573743600-1573747200@www.mbi.nus.edu.sg
SUMMARY:Integrin Signalling Generated Nanodomains As An Integrator Of Substrate Encoded Mechano-Chemical Signals by Joseph Mathew
DESCRIPTION:MBI Seminar\nWe are pleased to inform you on the seminar by Mr Joseph Mathew\, hosted by A/Prof Toyama Yusuke “Integrin Signalling Generated Nanodomains As An Integrator Of Substrate Encoded Mechano-Chemical Signals” on 14 Nov @3pm at T-Lab Level 5 Seminar Rooms.
URL:https://www.mbi.nus.edu.sg/event/integrin-signalling-generated-nanodomains-as-an-integrator-of-substrate-encoded-mechano-chemical-signals-by-joseph-mathew/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191115T100000
DTEND;TZID=Asia/Singapore:20191115T110000
DTSTAMP:20260410T124106
CREATED:20191111T052337Z
LAST-MODIFIED:20191111T052551Z
UID:27850-1573812000-1573815600@www.mbi.nus.edu.sg
SUMMARY:MBIw: Towards an innovative High Content Screening platform for organoids and its biomedical applications by Anne Beghin
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am – 11.00am\nDate: Friday\, 15 Nov 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nTowards an innovative High Content Screening platform for organoids and its biomedical applications\nBy Anne Beghin\, Senior Research Fellow\, Viasnoff Group\, Mechanobiology Institute \n 
URL:https://www.mbi.nus.edu.sg/event/mbiw-towards-an-innovative-high-content-screening-platform-for-organoids-and-its-biomedical-applications-by-anne-beghin/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191115T160000
DTEND;TZID=Asia/Singapore:20191115T170000
DTSTAMP:20260410T124106
CREATED:20191104T022151Z
LAST-MODIFIED:20191104T022151Z
UID:27816-1573833600-1573837200@www.mbi.nus.edu.sg
SUMMARY:EMBO Member Lecture: Mechano-Genomics: From cell-fate decisions to biomarkers by G.V. Shivashankar
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/embo-member-lecture-mechano-genomics-from-cell-fate-decisions-to-biomarkers-by-g-v-shivashankar/
LOCATION:DBS Conference Room 1\, 14 Science Drive 4\, Singapore\, 117543\, Singapore
CATEGORIES:DBS Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191119T100000
DTEND;TZID=Asia/Singapore:20191119T110000
DTSTAMP:20260410T124106
CREATED:20191118T025141Z
LAST-MODIFIED:20191118T025141Z
UID:27874-1574157600-1574161200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Introduction to magnetic tweezers\, its applications\, and development in MBI by Lu Chen
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 19 November 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nIntroduction to magnetic tweezers\, its applications\, and development in MBI\nBy Lu Chen\, PhD Student\, Yan Jie Group \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-introduction-to-magnetic-tweezers-its-applications-and-development-in-mbi-by-lu-chen/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191122T160000
DTEND;TZID=Asia/Singapore:20191122T170000
DTSTAMP:20260410T124106
CREATED:20191114T013418Z
LAST-MODIFIED:20191212T033537Z
UID:27865-1574438400-1574442000@www.mbi.nus.edu.sg
SUMMARY:MBI Graduate Student Club Career Talk featuring Bhumika Aggarwal and (GlaxoSmithKline) and Dipti Thakkar (Hummingbird Bioscience)
DESCRIPTION:MBI Graduate Student Career Talk\nThe MBI Graduate Student Club is pleased to invite you to a Career talk event with industry professionals Dr. Bhumika Aggarwal (GlaxoSmithKline) and Dr. Dipti Thakkar (Hummingbird Bioscience). They will be presenting insights on their own career journeys and sharing tips and tricks about the current job market. You will also get the chance to interact with them informally after the talks over coffee. \nThe event details are as follows: \nDate: Nov 22\, 2019 (Friday)\nTime: 4:00 – 5:30 pm\nVenue: Level 5 Seminar Room \nSpeakers\nDr. Bhumika Aggarwal\, Medical Director\, GlaxoSmithKline\nDr. Bhumika Aggarwal is a Medical Director at GlaxoSmithKline\, Singapore. She specializes in respiratory medicine and has 9 years of experience in the biomedical industry\, developing medical plans and ensuring effective scientific communication. \nDr. Dipti Thakkar\, Head of Discovery\, Hummingbird Bioscience\nDr Dipti Thakkar is a Principal Scientist (Head of Discovery) at Hummingbird Biosciences. She trained as a molecular oncologist during her doctoral and post-doctoral research. Her current focus in the pharmaceutical industry is drug discovery for cancer therapeutics. \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-graduate-student-club-career-talk-featuring-bhumika-aggarwal-and-glaxosmithkline-and-dipti-thakkar-hummingbird-bioscience/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Career Talk,MBI Graduate Student Club,MBI WIS
ATTACH;FMTTYPE=image/png:https://www.mbi.nus.edu.sg/wp-content/uploads/2019/11/2019-22-careerTalk.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191122T190000
DTEND;TZID=Asia/Singapore:20191122T200000
DTSTAMP:20260410T124106
CREATED:20191114T012450Z
LAST-MODIFIED:20191114T012450Z
UID:27862-1574449200-1574452800@www.mbi.nus.edu.sg
SUMMARY:DBS Seminar: Transgenic salmon--serendipity\, entrepreneurship and perseverance by Hew Choy Leong
DESCRIPTION:As part of the celebration Singapore’s bicentennial\, Faculty of Science’s 90th Anniversary & Department of Biological Sciences’ 70th Anniversary\, Professors from the Department of Biological Sciences had been sharing their research journeys through public lectures. As we approach the end of 2019\, to cap off the lecture series\, our department will have Emeritus Professor Hew Choy Leong to share his research journey on the transgenic salmon in November. This is the world’s first genetically engineered animal that was approved by FDA to be safe for consumption.
URL:https://www.mbi.nus.edu.sg/event/dbs-seminar-transgenic-salmon-serendipity-entrepreneurship-and-perseverance-by-hew-choy-leong/
LOCATION:National University of Singapore
CATEGORIES:DBS Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191126T100000
DTEND;TZID=Asia/Singapore:20191126T103000
DTSTAMP:20260410T124106
CREATED:20191122T063512Z
LAST-MODIFIED:20191122T063512Z
UID:27882-1574762400-1574764200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Spatiotemporal control of FGFR activation during Drosophila development by Vaishali Yadav
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 26 November 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nSpatiotemporal control of FGFR activation during Drosophila development\nBy Vaishali Yadav\, PhD Student\, Saunders Group \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-spatiotemporal-control-of-fgfr-activation-during-drosophila-development-by-vaishali-yadav/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191126T103000
DTEND;TZID=Asia/Singapore:20191126T110000
DTSTAMP:20260410T124106
CREATED:20191122T063616Z
LAST-MODIFIED:20191122T063616Z
UID:27884-1574764200-1574766000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Laser Ablation: System and Applications by Yusuke Toyama
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 10.00am – 11.00am\nDate: Tuesday\, 26 November 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nLaser Ablation: System and Applications\nBy Yusuke Toyama\, Associate Professor\, Mechanobiology Institute and Teng Xiang\, Research Associate\, Toyama Group \n  \nPlease note this event is open to MBI researchers and invited guests only.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-laser-ablation-system-and-applications-by-yusuke-toyama/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191126T120000
DTEND;TZID=Asia/Singapore:20191126T130000
DTSTAMP:20260410T124106
CREATED:20191108T081017Z
LAST-MODIFIED:20191108T081017Z
UID:27842-1574769600-1574773200@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense: Role Of Active Cytoskeletal Forces & Nuclear Lamina In Regulating The Spatiotemporal Chromatin Architecture by JOKHUN Doorgesh Sharma
DESCRIPTION:MBI PhD Oral Defense\nTime: 12noon\nDate: Tuesday\, 26 November 2019\nVenue: T-Lab Building\, Level 5 Seminar Rooms \nSupervisor: Prof. G.V. Shivashankar \nRole Of Active Cytoskeletal Forces & Nuclear Lamina In Regulating The Spatiotemporal Chromatin Architecture\nby JOKHUN Doorgesh Sharma\, Shiva’s Group \nExtracellular signals need to be transmitted to the nucleus and chromatin to regulate genomic processes and elicit proper cell response. In addition to signalling pathways\, the actin cytoskeleton serves as an important mechanical connection for the propagation of physical signals from outside the cell to the nucleus. While many studies have investigated the role of the actomyosin network in directly transmitting stresses\, in this work\, we focussed on the intrinsically dynamic nature of the actin cytoskeleton as a means of relaying extracellular signals. We showed that the cytoskeletal network continuously reorganizes and applies dynamic forces on the nucleus even under static extracellular conditions. Further\, we used the positional dynamics of telomeres as a handle to sample local chromatin dynamics inside the nucleus. We demonstrated that active cytoskeletal fluctuations feed into the spatiotemporal regulation of chromatin architecture in an extracellular signal-dependent manner. Further\, we showed that lamin A/C mechanically couples distal chromatin loci thereby limiting their diffusion characteristics and causing them to exhibit correlated motion. We established that such changes in the translational dynamics of chromatin\, more specifically that of telomeric chromatin\, impinges upon the binding kinetics of essential chromatin binding proteins. Taken together\, our results demonstrate the roles played by the dynamic actin cytoskeleton and nuclear lamina in transmitting extracellular information to the chromatin. In addition\, we underscored the link between chromatin organization and cellular state by demonstrating that a multivariate analysis of quantitative nuclear and chromatin architectural features efficiently classifies cells of different types. We further validated the sensitivity of the method by detecting subtle nuclear changes such as those obtained with TNF-α stimulation. Collectively\, this thesis establishes chromatin organization as a hub for integrating extracellular signals into genome regulation while concurrently reflecting cellular state. Consequently\, quantitative descriptions of chromatin architecture can potentially be exploited as biomarkers for novel image-based diagnostic systems. \n  \n**Please note the examination following the seminar is closed-door** \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-role-of-active-cytoskeletal-forces-nuclear-lamina-in-regulating-the-spatiotemporal-chromatin-architecture-by-jokhun-doorgesh-sharma/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191126T143000
DTEND;TZID=Asia/Singapore:20191126T153000
DTSTAMP:20260410T124106
CREATED:20191114T020934Z
LAST-MODIFIED:20191114T020934Z
UID:27869-1574778600-1574782200@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense: Interrelationship Between Contractility And Dynamics Of Actomyosin System In Non-Muscle Cells by Shi Shidong
DESCRIPTION:MBI PhD Oral Defense\nTime: 2.30pm\nDate: Tuesday\, 26 November 2019\nVenue: T-Lab\, Level 5 Meeting Room 1 \nSupervisors: Prof. Virgile Viasnoff and Prof. Alexander Bershadsky \nInterrelationship Between Contractility And Dynamics Of Actomyosin System In Non-Muscle Cells\nby SHI Shidong\, Viasnoff’s Group \nContractile actomyosin stress fiber (SF) systems in non-muscle cells are essential for a variety of cellular processes including adhesion and morphogenesis. While transmitting long-sustained non-muscle myosin II (NM II)-generated force to the substrate through focal adhesions (FAs)\, ventral stress fiber (VSF) is surprisingly a highly dynamic system subjected to constant polymerization and depolymerization. However\, how actin dynamics (in particular\, polymerization-depolymerization driven flow along the fibers) and NM II dependent contractility are related to each other in matured VSFs still remains elusive. To this end\, I manipulated either actin polymerization or forces in VSFs to investigate how they influence one another. Surprisingly\, pharmacological inhibitors SMIFH2 (an inhibitor of formin-family proteins) strongly inhibited the forces exerted by VSFs onto the substrates. I hence proposed that besides working as actin elongation factors\, formins could physically link actin filaments with each other\, thus participating in both actin polymerization and force transmission processes. On the other hand\, drug inhibition of NM II generated forces prevented actin polymerization along VSFs. Furthermore\, cyclic stretching rescued the actin polymerization in cells with inhibited formins\, but not in cells with inhibited NM II. Therefore\, I hypothesized that NM II generated force may feedback to mechano-sensitive formins to regulate actin polymerization while the counter forces generated by NM II filaments are essential for the force transmission along VSFs.       Our results revealed that VSFs are dynamic viscoelastic systems\, in which NM II driven contractility and actin dynamics are fine-tuned with each other. \n  \n**Please note the examination following the seminar is closed-door**
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-interrelationship-between-contractility-and-dynamics-of-actomyosin-system-in-non-muscle-cells-by-shi-shidong/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191126T160000
DTEND;TZID=Asia/Singapore:20191126T170000
DTSTAMP:20260410T124106
CREATED:20191111T073115Z
LAST-MODIFIED:20191111T073115Z
UID:27856-1574784000-1574787600@www.mbi.nus.edu.sg
SUMMARY:Compartmentalized Archipelago Architecture Of Focal Adhesion Revealed By Super-Long And Ultrafast Single-Molecule Imaging Techniques by Taka-Aki Tsunoyama & Akihiro Kusumi
DESCRIPTION:We are pleased to inform you on the seminar by Dr Taka-Aki Tsunoyama & Prof Akihiro Kusumi\, hosted by A/Prof Tony Kanchanawong “Compartmentalized Archipelago Architecture Of Focal Adhesion Revealed By Super-Long And Ultrafast Single-Molecule Imaging Techniques” on 26 Nov@4pm at T-Lab Level 5 Meeting Room 1.
URL:https://www.mbi.nus.edu.sg/event/compartmentalized-archipelago-architecture-of-focal-adhesion-revealed-by-super-long-and-ultrafast-single-molecule-imaging-techniques-by-taka-aki-tsunoyama-akihiro-kusumi/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191127T140000
DTEND;TZID=Asia/Singapore:20191127T173000
DTSTAMP:20260410T124106
CREATED:20191101T021938Z
LAST-MODIFIED:20191101T021938Z
UID:27808-1574863200-1574875800@www.mbi.nus.edu.sg
SUMMARY:An Afternoon of Talks with Prof Hilary Lappin-Scott\, OBE\, Swansea University
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/an-afternoon-of-talks-with-prof-hilary-lappin-scott-obe-swansea-university/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI WIS,Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191129T100000
DTEND;TZID=Asia/Singapore:20191129T110000
DTSTAMP:20260410T124106
CREATED:20191202T010742Z
LAST-MODIFIED:20191202T010742Z
UID:27913-1575021600-1575025200@www.mbi.nus.edu.sg
SUMMARY:MBIw: Spatio-temporal Organization and Dynamics of Human DNA Replication Foci Mediated by CTCF-organized Chromatin Structures by Ziqing (Winston) ZHAO
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am – 11.00am\nDate: Friday\, 29 Nov 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nSpatio-temporal Organization and Dynamics of Human DNA Replication Foci Mediated by CTCF-organized Chromatin Structures\nby Ziqing (Winston) ZHAO\, Department of Chemistry / Centre for BioImaging Sciences\, NUS
URL:https://www.mbi.nus.edu.sg/event/mbiw-spatio-temporal-organization-and-dynamics-of-human-dna-replication-foci-mediated-by-ctcf-organized-chromatin-structures-by-ziqing-winston-zhao/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191129T170000
DTEND;TZID=Asia/Singapore:20191129T180000
DTSTAMP:20260410T124106
CREATED:20191127T010936Z
LAST-MODIFIED:20191127T010936Z
UID:27905-1575046800-1575050400@www.mbi.nus.edu.sg
SUMMARY:Thanks and farewell high tea with Prof Shivashankar
DESCRIPTION:Dear Colleagues\, \nAs you are aware\, I will be relocating to a professorship in Mechano-Genomics at ETH Zurich jointly with the Paul Scherrer Institute\, Switzerland\, starting in January 2020. I was very happy to have been part of MBI and NUS for the last 10 years. I am writing to invite you for a high tea to express my sincere thanks to all of you to have supported our research program and for the warm friendships during my tenure at NUS. Many thanks. \nbest\,\nShiva
URL:https://www.mbi.nus.edu.sg/event/thanks-and-farewell-high-tea-with-prof-shivashankar/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:social
END:VEVENT
END:VCALENDAR