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PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
REFRESH-INTERVAL;VALUE=DURATION:PT1H
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BEGIN:VTIMEZONE
TZID:Asia/Singapore
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:+08
DTSTART:20180101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190507T093000
DTEND;TZID=Asia/Singapore:20190507T103000
DTSTAMP:20260409T152602
CREATED:20190508T051904Z
LAST-MODIFIED:20190508T051904Z
UID:26441-1557221400-1557225000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Unfolding alpha-helix proteins at low force by Pang Si Ming
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\, 7 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nUnfolding alpha-helix proteins at low force\nby Pang Si Ming\, Yan Jie Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-unfolding-alpha-helix-proteins-at-low-force-by-pang-si-ming/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190510T093000
DTEND;TZID=Asia/Singapore:20190510T103000
DTSTAMP:20260409T152602
CREATED:20190508T052135Z
LAST-MODIFIED:20190508T053203Z
UID:26443-1557480600-1557484200@www.mbi.nus.edu.sg
SUMMARY:MBIw: Repurposing Nature: Opportunities for Protein Assemblies at Interfaces by Lim Sierin
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 10 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nRepurposing Nature: Opportunities for Protein Assemblies at Interfaces\nby Prof. Lim Sierin\, Associate Dean and Associate Professor\, Nanyang Technological University (NTU) Singapore. \nNature provides us with an abundance of biological materials that we have been repurposing to suit our needs. In this talk\, I will highlight self-assembling protein subunits that form hollow cage-like structures\, called protein cages. Protein cages have been investigated as potential molecular carriers. However\, tuning the release rate of encapsulated molecules from these protein cages is a challenge. We hypothesize that by rationally modulating the protein-protein interactions between the protein cage subunits\, the release of molecular cargo from the lumen can be tuned. To test the hypothesis\, we introduced modifications at the intersubunit interface and the interaction surfaces between two molecules by introducing non-native histidines or substituting the interacting surfaces with other peptide sequences. The effects of the modifications were characterized at various pH-s. The results show that rational modifications of protein-protein interactions have implications on the self-assembly and hence\, release rate of the encapsulated molecules. \nIn recent studies\, we found that these protein cages form an ensemble that stabilize oil droplets in water by localizing at the oil-water interface and forming Pickering emulsion. However\, their behavior and structural integrity at this interface is rarely studied. Our works elucidate the unique behavior of the protein nanocages that is distinct from other small (monomeric/dimeric) proteins. The protein cage-stabilized emulsion is pH-responsive. \nIn conclusion\, protein cages can serve as an individual molecular carrier or as an ensemble that stabilizes an emulsion and present many opportunities that are yet to be explored.
URL:https://www.mbi.nus.edu.sg/event/repurposing-nature-opportunities-for-protein-assemblies-at-interfaces-by-lim-sierin/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190514T093000
DTEND;TZID=Asia/Singapore:20190514T103000
DTSTAMP:20260409T152602
CREATED:20190509T084826Z
LAST-MODIFIED:20190509T084826Z
UID:26457-1557826200-1557829800@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Implementing Optogenetic Modulation in Mechanotransduction by Yu Miao
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\, 14 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nImplementing Optogenetic Modulation in Mechanotransduction\nby Yu Miao\, Research Fellow\, Yan Jie Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-implementing-optogenetic-modulation-in-mechanotransduction-by-yu-miao/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190516T160000
DTEND;TZID=Asia/Singapore:20190516T170000
DTSTAMP:20260409T152602
CREATED:20190515T014642Z
LAST-MODIFIED:20190515T014642Z
UID:26469-1558022400-1558026000@www.mbi.nus.edu.sg
SUMMARY:Cardiomyocyte adhesion complexes and their linkage to the cytoskeleton by Adam Kwiatkowski
DESCRIPTION:We are pleased to inform you on the seminar of MBI Seminar: Dr Adam Kwiatkowski\, hosted by Prof Yan Jie “Cardiomyocyte adhesion complexes and their linkage to the cytoskeleton” on 16 May (Thur) @4pm at T-Lab Level 5 Seminar Rooms. 
URL:https://www.mbi.nus.edu.sg/event/cardiomyocyte-adhesion-complexes-and-their-linkage-to-the-cytoskeleton-by-adam-kwiatkowski/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190517T093000
DTEND;TZID=Asia/Singapore:20190517T103000
DTSTAMP:20260409T152602
CREATED:20190513T085035Z
LAST-MODIFIED:20190513T085035Z
UID:26460-1558085400-1558089000@www.mbi.nus.edu.sg
SUMMARY:MBIw: Quantification of membrane receptor complexes with single-molecule localization microscopy by Mike Heilemann
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 17 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nQuantification of membrane receptor complexes with single-molecule localization microscopy\nby Prof Mike Heilemann (hosted by Prof. Linda Kenney)\, Goethe University Frankfurt
URL:https://www.mbi.nus.edu.sg/event/mbiw-quantification-of-membrane-receptor-complexes-with-single-molecule-localization-microscopy-by-mike-heilemann/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190517T120000
DTEND;TZID=Asia/Singapore:20190517T130000
DTSTAMP:20260409T152602
CREATED:20190508T091936Z
LAST-MODIFIED:20190508T093955Z
UID:26446-1558094400-1558098000@www.mbi.nus.edu.sg
SUMMARY:NUS Physiology Research Seminar: Imagining salmonella lifestyles + career talk by Linda Kenney
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/imagining-salmonella-lifestyles-career-talk-by-linda-kenney/
LOCATION:MD9 Department of Physiology\, 2 Medical Drive MD9\, Singapore\, 117593\, Singapore
CATEGORIES:MBI WIS
ATTACH;FMTTYPE=image/jpeg:https://www.mbi.nus.edu.sg/wp-content/uploads/2019/05/2019-05-Kenney.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190521T093000
DTEND;TZID=Asia/Singapore:20190521T103000
DTSTAMP:20260409T152602
CREATED:20190516T015047Z
LAST-MODIFIED:20190516T015047Z
UID:26475-1558431000-1558434600@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Remote Controlled Cells – Hijacking Talin with Chemically Induced Dimerisers and Optogeneticsby Samuel Barnett
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\, 21 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nRemote Controlled Cells – Hijacking Talin with Chemically Induced Dimerisers and Optogenetics\nby Samuel Barnett\, Research Fellow\, Kanchanawong Group \n  \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-remote-controlled-cells-hijacking-talin-with-chemically-induced-dimerisers-and-optogeneticsby-samuel-barnett/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190521T140000
DTEND;TZID=Asia/Singapore:20190521T160000
DTSTAMP:20260409T152602
CREATED:20190516T020051Z
LAST-MODIFIED:20190516T020051Z
UID:26477-1558447200-1558454400@www.mbi.nus.edu.sg
SUMMARY:MBI welcomes Senior Minister of State Chee Hong Tat and Senior Parliamentary Secretary Tan Wu Meng from the Ministry of Trade and Industry
DESCRIPTION:We are pleased to inform that MBI will be receiving a visit from the Senior Minister of State Mr. Chee Hong Tat and Senior Parliamentary Secretary Dr. Tan Wu Meng from the Ministry of Trade and Industry  on : \nDate:  21 May 2019\nTime : 2 – 4.30 pm\nVenue : T-Lab level 5 seminar room and T-Lab level 9 MBI Labs/Microscopy Core Facility \nThis visit will be attended also by OSHE director Dr. Peck Thian Guan and NUS Deputy President of Research and Technology Prof. Chen Tsuhan. \nT-Lab lifts may be held up for short periods during the day of visit and we seek your understanding and patience. The Microscopy room will be crowded with visitors for a window of 3.30 – 4 pm on visit day as well.
URL:https://www.mbi.nus.edu.sg/event/mbi-welcomes-senior-minister-of-state-chee-hong-tat-and-senior-parliamentary-secretary-tan-wu-meng-from-the-ministry-of-trade-and-industry/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:Outreach Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190522T170000
DTEND;TZID=Asia/Singapore:20190522T180000
DTSTAMP:20260409T152602
CREATED:20190515T042208Z
LAST-MODIFIED:20190515T042237Z
UID:26472-1558544400-1558548000@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Qualifying Exam: The Role of SsrB in Salmonella Typhimurium Lifestyle by Dasvit Shetty
DESCRIPTION:MBI PhD Qualifying Exam\nTime: 5pm\nDate: 22 May 2019\, Wednesday\nVenue: MBI\, Level 5 Meeting Room. \nSupervisor: Dr Linda J. Kenney \nThe Role of SsrB in Salmonella Typhimurium Lifestyle\nby Dasvit SHETTY\, Kenney Group \nAbstract\nSsrB is a response regulator that controls the induction of SPI-2 genes during the intracellular phase of Salmonella Typhimurium infection. SsrB is a NarL/FixJ family response regulator and is phosphorylated by its associated sensor kinase SsrA in order to activate SPI-2 genes. An unphosphorylated SsrB mutant\, D56A\, was discovered to regulate the master biofilm regulator csgD\, thus functioning as a lifestyle switch between the infectious and carrier states of the pathogen. This discovery led to an RNA-seq analysis to investigate more genes that might be under SsrB control during the non-virulent lifestyle. Analysis of the RNA-seq data of wild-type and DssrB strains in biofilm-inducing conditions showed down-regulation of many stress response genes in the DssrB strain\, most notably dksA\, dsrA and hfq genes. These genes are known regulators of the ancestral stress sigma factor RpoS; and were unaffected in the D56AssrB strain. This study aims to explore the role of SsrB in its non-canonical regulation of RpoS through DksA\, DsrA and Hfq. \nAlthough D56A SsrB has been shown to bind to DNA using AFM\, it is unknown whether its binding affinity is comparable to wild-type phosphorylated SsrB (SsrB~P). Measuring the dissociation constants of D56A SsrB and SsrB~P to its known cognate promoters using a single molecule unzipping assay will assist in understanding the role of phosphorylation in DNA affinity and promoter-specificity of SsrB. Another unique characteristic of SsrB among NarL/FixJ regulators is its increased DNA binding at low pH. Residues in SsrB that influence this property and the molecular mechanism are not known. Hence\, this study aims to use NMR and a single molecule unzipping assay to elucidate the basis of the increased DNA affinity of SsrB at low pH. \n  \n**Please note the examination following the seminar is closed-door**
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-qualifying-exam-the-role-of-ssrb-in-salmonella-typhimurium-lifestyle-by-dasvit-shetty/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190524T093000
DTEND;TZID=Asia/Singapore:20190524T103000
DTSTAMP:20260409T152602
CREATED:20190522T023058Z
LAST-MODIFIED:20190522T023058Z
UID:26519-1558690200-1558693800@www.mbi.nus.edu.sg
SUMMARY:MBIw: Information Content of Cortical Traveling Waves by Wu Min
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 24 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nInformation Content of Cortical Traveling Waves\nby Wu Min\, Associate Professor\, Mechanobiology Institute\, National University of Singapore \n  \nThank you!
URL:https://www.mbi.nus.edu.sg/event/mbiw-information-content-of-cortical-traveling-waves-by-wu-min/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190527T100000
DTEND;TZID=Asia/Singapore:20190527T110000
DTSTAMP:20260409T152602
CREATED:20190522T012322Z
LAST-MODIFIED:20190527T015626Z
UID:26516-1558951200-1558954800@www.mbi.nus.edu.sg
SUMMARY:NGS PhD Oral Defense: Multifunctional Cellulosic Sponge for In Vitro 3D Spheriod Culture by Liu Zheng
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/ngs-phd-oral-defense-multifunctional-cellulosic-sponge-for-in-vitro-3d-spheriod-culture-by-liu-zheng/
LOCATION:National University of Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190528T093000
DTEND;TZID=Asia/Singapore:20190528T100000
DTSTAMP:20260409T152602
CREATED:20190522T035824Z
LAST-MODIFIED:20190522T035824Z
UID:26521-1559035800-1559037600@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Shaping of the ventral nerve cord during Drosophila embryogenesis by Prabhat Tiwari
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\, 28 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nShaping of the ventral nerve cord during Drosophila embryogenesis \nby Prabhat Tiwari\, Research Fellow\, Saunders Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-shaping-of-the-ventral-nerve-cord-during-drosophila-embryogenesis-by-prabhat-tiwari/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190528T100000
DTEND;TZID=Asia/Singapore:20190528T103000
DTSTAMP:20260409T152602
CREATED:20190522T035958Z
LAST-MODIFIED:20190522T035958Z
UID:26523-1559037600-1559039400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Interrelationship between actin incorporation and force generation in ventral stress fibers (VSFs) by Shi Shidong
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\, 28 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nInterrelationship between actin incorporation and force generation in ventral stress fibers (VSFs) \nby Shi Shidong\, PhD Student\, Bershadsky and Viasnoff Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-interrelationship-between-actin-incorporation-and-force-generation-in-ventral-stress-fibers-vsfs-by-shi-shidong/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190529T100000
DTEND;TZID=Asia/Singapore:20190529T123000
DTSTAMP:20260409T152602
CREATED:20190527T064751Z
LAST-MODIFIED:20190527T064751Z
UID:26542-1559124000-1559133000@www.mbi.nus.edu.sg
SUMMARY:MBI welcomes members of City University of Hong Kong
DESCRIPTION:There will be a MBI Outreach Visit by City University of Hong Kong on 29th May\, Wednesday: \nDate: 29th May 2019\, Wednesday\nTime: 10.00am – 12.30pm\nLab demonstrations: estimated to be from 11.00am – 12.20pm as follows: \nSchedule\n11.00am – 11.40am \n– Superresolution (L9 NSTORM System Room 7)\n– Microfabrication (L9 Lab Benches) \n11.40am – 12.20pm \n– Widefield Fluorescence Microscope (L10 Room 1\, Delta Vision)\n– Plasmid Isolation and Agarose Gel Electrophoresis (L10 Lab Benches 03A) \nTherefore\, we would like to request your kind cooperation to plan your experiments with this in mind\, so as to ensure the smooth progress of the lab demos from 11.00am – 12.20pm.
URL:https://www.mbi.nus.edu.sg/event/mbi-welcomes-members-of-city-university-of-hong-kong/
LOCATION:MBI Level 10 Lobby\, 5A Engineering Drive 1\, Singapore\, 117411\, Singapore
CATEGORIES:Outreach Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190531T093000
DTEND;TZID=Asia/Singapore:20190531T103000
DTSTAMP:20260409T152602
CREATED:20190527T064351Z
LAST-MODIFIED:20190527T064351Z
UID:26540-1559295000-1559298600@www.mbi.nus.edu.sg
SUMMARY:MBIw: Interplay between actin polymerization\, myosin IIA filaments\, microtubules\, and integrin adhesions in cell morphogenesis by Alexander Bershadsky
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 31 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nInterplay between actin polymerization\, myosin IIA filaments\, microtubules\, and integrin adhesions in cell morphogenesis\nby Prof. Alexander Bershadsky\, Professor and Principal Investigator\, Mechanobiology Institute\, National University of Singapore \n 
URL:https://www.mbi.nus.edu.sg/event/mbiw-interplay-between-actin-polymerization-myosin-iia-filaments-microtubules-and-integrin-adhesions-in-cell-morphogenesis-by-alexander-bershadsky/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
END:VCALENDAR