BEGIN:VCALENDAR
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PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN
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X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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BEGIN:VTIMEZONE
TZID:Asia/Singapore
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:+08
DTSTART:20180101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190109T130000
DTEND;TZID=Asia/Singapore:20190109T153000
DTSTAMP:20260419T100028
CREATED:20190104T091748Z
LAST-MODIFIED:20190104T091748Z
UID:25548-1547038800-1547047800@www.mbi.nus.edu.sg
SUMMARY:MBI welcomes GLEAP Programme students from Seoul National University
DESCRIPTION:There will be an upcoming student visit by the GLEAP programme from Seoul National University as part of their visit to NUS as follows: \nDate: 9th January\, Wednesday\nTime: 1.00 – 3.30PM\nPax: estimated 20 students \nLab demonstrations: estimated to be from 2.00 – 3.15PM \n\nMicrofabrication (L9 uFab core wet bench)\nSuperresolution (L9 microscopy room 7\, NSTORM system)\nMicropatterning (L10 Tissue Culture Room)
URL:https://www.mbi.nus.edu.sg/event/mbi-welcomes-gleap-programme-students-from-seoul-national-university/
LOCATION:National University of Singapore
CATEGORIES:Outreach Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190111T093000
DTEND;TZID=Asia/Singapore:20190111T103000
DTSTAMP:20260419T100029
CREATED:20190108T092424Z
LAST-MODIFIED:20190108T092424Z
UID:25559-1547199000-1547202600@www.mbi.nus.edu.sg
SUMMARY:MBIw: Mechanical signals in plant systems by Olivier Hamant
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 11 January 2019\nVenue: Level 5 Seminar Room\, T-Lab \nMechanical signals in plant systems\nBy Olivier Hamant\, Director of Research\, École normale supérieure (ENS)\, Lyon\, France.
URL:https://www.mbi.nus.edu.sg/event/mbiw-mechanical-signals-in-plant-systems-by-olivier-hamant/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190115T093000
DTEND;TZID=Asia/Singapore:20190115T103000
DTSTAMP:20260419T100029
CREATED:20190109T092124Z
LAST-MODIFIED:20190109T092124Z
UID:25592-1547544600-1547548200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: A role of actin polymerization for force generation in stress fibers by Yukako Nishimura
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\,  15 January 2019\nVenue: Level 5 Seminar Room\, T-Lab \nA role of actin polymerization for force generation in stress fibers\nBy Yukako Nishimura\, Research Fellow\, Bershadsky Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-a-role-of-actin-polymerization-for-force-generation-in-stress-fibers-by-yukako-nishimura/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190115T160000
DTEND;TZID=Asia/Singapore:20190115T170000
DTSTAMP:20260419T100029
CREATED:20181228T035201Z
LAST-MODIFIED:20181228T035201Z
UID:25536-1547568000-1547571600@www.mbi.nus.edu.sg
SUMMARY:Beyond The Diffraction Limit By Lightsheet Microscopy by Chen Bi-Chang
DESCRIPTION:We are pleased to inform you on the seminar by Dr Chen Bi-Chang “Beyond The Diffraction Limit By Lightsheet Microscopy ” on 15 Jan (Tue) @4pm at T-Lab Level 5 Seminar Rooms.
URL:https://www.mbi.nus.edu.sg/event/beyond-the-diffraction-limit-by-lightsheet-microscopy-by-chen-bi-chang/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190115T160000
DTEND;TZID=Asia/Singapore:20190115T170000
DTSTAMP:20260419T100029
CREATED:20190111T020610Z
LAST-MODIFIED:20190111T020610Z
UID:25600-1547568000-1547571600@www.mbi.nus.edu.sg
SUMMARY:BIGHEART: Lectures on Microfluidics and Nanofluidics By Professor Takehiko Kitamori
DESCRIPTION:BIGHEART Distinguished Speaker Series\nLectures on Microfluidics and Nanofluidics By Professor Takehiko Kitamori\nLecture II: Design Method\nTuesday\, 15 Jan 2019\, 4:00 – 5:00 pm\nBIGHEART Lounge\, MD6 Level 14\,\n14 Medical Drive\, S117599 \nLecture III: Fabrication\nWednesday\, 16 Jan 2019\, 4:00 – 5:00 pm\nBIGHEART Lounge\, MD6 Level 14\,\n14 Medical Drive\, S117599
URL:https://www.mbi.nus.edu.sg/event/bigheart-lectures-on-microfluidics-and-nanofluidics-by-professor-takehiko-kitamori/
LOCATION:BIGHEART Seminar\, CeLS Seminar Room 1\, Singapore\, 117456\, Singapore
CATEGORIES:Biomedical Institute for Global Health Research & Technology (BIGHEART)
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190122T093000
DTEND;TZID=Asia/Singapore:20190122T170000
DTSTAMP:20260419T100029
CREATED:20190117T041936Z
LAST-MODIFIED:20190117T042329Z
UID:25615-1548149400-1548176400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Ion channels in the mechanosensing of normal and transformed cells by Yao Mingxi
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\,  22 January 2019\nVenue: Level 5 Seminar Room\, T-Lab \nIon channels in the mechanosensing of normal and transformed cells\nBy Yao Mingxi\, Research Fellow\, Sheetz Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-ion-channels-in-the-mechanosensing-of-normal-and-transformed-cells-by-yao-mingxi/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190125T093000
DTEND;TZID=Asia/Singapore:20190125T103000
DTSTAMP:20260419T100029
CREATED:20190122T062858Z
LAST-MODIFIED:20190122T062858Z
UID:25657-1548408600-1548412200@www.mbi.nus.edu.sg
SUMMARY:Stability of mechanosensing force-transmission pathways by Yan Jie
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 25 January 2019\nVenue: Level 5 Seminar Room\, T-Lab \nStability of mechanosensing force-transmission pathways\nby Prof. Yan Jie\, Professor\, Mechanobiology Institute\, National University of Singapore \n 
URL:https://www.mbi.nus.edu.sg/event/stability-of-mechanosensing-force-transmission-pathways-by-yan-jie/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190129T093000
DTEND;TZID=Asia/Singapore:20190129T103000
DTSTAMP:20260419T100029
CREATED:20190124T014138Z
LAST-MODIFIED:20190125T032810Z
UID:25686-1548754200-1548757800@www.mbi.nus.edu.sg
SUMMARY:How does hormone signaling control cellular functions? :Competition for downstream signaling molecules between ligand-activated RTKs\, or between RTKs and focal adhesisons. by Oh Dongmyung
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\,  29 January 2019\nVenue: Level 5 Seminar Room\, T-Lab \nHow does hormone signaling control cellular functions?:Competition for downstream signaling molecules between ligand-activated RTKs\, or between RTKs and focal adhesisons.\nby Dr. Oh Dongmyung\, Research Fellow\, Sheetz Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/how-does-hormone-signaling-control-cellular-functionscompetition-for-downstream-signaling-molecules-between-ligand-activated-rtks-or-between-rtks-and-focal-adhesisons-by-oh-dongmyung/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190130T150000
DTEND;TZID=Asia/Singapore:20190130T160000
DTSTAMP:20260419T100029
CREATED:20190123T015535Z
LAST-MODIFIED:20190123T015535Z
UID:25660-1548860400-1548864000@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense: Nanoscale Organization of Integrin-Based Adhesion Complexes and Cortical Actin Cytoskeleton in Mouse Embryonic Stem Cells by Xia Shumin
DESCRIPTION:MBI PhD Oral Defense\nTime: 3pm\nDate: Wednesday\, 30 January 2019\nVenue: NUS\, E3-06-03 Tutorial Room \nSupervisor: Prof Kanchanawong\, Pakorn (main supervisor) and Prof Evelyn Yim (co supervisor) \nNanoscale Organization of Integrin-Based Adhesion Complexes and Cortical Actin Cytoskeleton in Mouse Embryonic Stem Cells\nby XIA Shumin\,  Kanchanawong Group \n  \nEmbryonic stem cells (ESCs) are uniquely valuable cell types due to their ability to proliferate indefinitely (self-renewal) and differentiate into any specialized lineage (pluripotency). Although ESCs has been widely utilized in regenerative medicine and tissue engineering via directed differentiation\, using either biochemical or biophysical cues\, several fundamental aspects of ESC biology remain not well understood.  In particular\, ESCs exhibit distinctively compliant nuclei and cell body which serve as a unique mechanical signature of the pluripotent state. Furthermore\, while mechanical cues\, such as substrate rigidity\, exert strong influence on many differentiated or multi-potent cell types\, ESCs are well-documented to elicit limited responses to such mechanical stimuli. While the actin cortex serves as a major determinant of animal cell mechanics and integrin-based adhesion complexes orchestrate key mechanosensitive responses through the connection between the extra cellular matrix (ECM) and actin cytoskeleton\, it is notable that these mechanobiological apparatuses have not been well characterized in ESCs. \nIn this thesis\, I sought to investigate whether the unusual cell mechanical properties of ESCs arise from any alternate organization or regulation of the actin cortex and/or the cell-matrix adhesions. Using super-resolution microscopy\, I found that the integrin-based adhesion complexes in mouse ESCs (mESCs) maintained the conserved nanoscale architecture and compositional maturation comparable to specialized cells\, despite their low density and peripheral localization. In contrast\, for the mESC actin cortex\, I observed a distinctive nanoscale organization consisting of low-density and <60 nm-thin isotropic meshwork interspersed with radial organization called “asters”. I demonstrated that the asters were transient sites of Arp2/3-dependent actin polymerization and that the architecture and mechanics of the mESC actin cortex appeared to be controlled by a multi-tier mechanism that modulates the network topological complexity and filament elongation through the balance between formin\, Arp2/3\, and capping protein. Surprisingly\, both the architecture and mechanical properties of the mESC actin cortex were largely independent of myosin II. I demonstrated that upon a pharmacological perturbation of cortical network density\, myosin II can be recruited into the mESC actin cortex\, suggesting that its incorporation can be gated by network density. Altogether\, these results provide the molecular and ultrastructural insights into key mechanobiological structures of pluripotent stem cells\, and help to elucidate the molecular mechanisms that may account for the unusual mechanical characteristics of mESCs\, primarily through the regulation of the actin cortex. \n  \n**Please note the examination following the seminar is closed-door** \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-nanoscale-organization-of-integrin-based-adhesion-complexes-and-cortical-actin-cytoskeleton-in-mouse-embryonic-stem-cells-by-xia-shumin/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190130T160000
DTEND;TZID=Asia/Singapore:20190130T170000
DTSTAMP:20260419T100029
CREATED:20190122T062545Z
LAST-MODIFIED:20190122T062545Z
UID:25654-1548864000-1548867600@www.mbi.nus.edu.sg
SUMMARY:Cell size sensing – a one-dimensional solution for a three-dimensional problem? by Mike Fainzilber
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/cell-size-sensing-a-one-dimensional-solution-for-a-three-dimensional-problem-by-mike-fainzilber/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
END:VCALENDAR