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X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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TZID:Asia/Singapore
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DTSTART:20170101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181203T150000
DTEND;TZID=Asia/Singapore:20181203T160000
DTSTAMP:20260419T200316
CREATED:20181127T012951Z
LAST-MODIFIED:20181127T012951Z
UID:25361-1543849200-1543852800@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense: Emergence of Coordinated Collective Cell Migration under Physical Confinement by Shreyansh Jain
DESCRIPTION:MBI PhD Oral Defense\nTime: 3pm\nDate: Monday\, 3 December 2018\nVenue: MBI\, level 5 meeting rooms \nSupervisors: Prof Lim Chwee Teck (Main supervisor) and Prof Benoit Ladoux (Co-supervisor) \nEmergence of Coordinated Collective Cell Migration under Physical Confinement\nby Shreyansh JAIN\, CT Lim’s Group \nDirected migration of cell collectives is essential in various physiological processes\, such as epiboly\, Drosophila dorsal closure\, and convergent extension during morphogenesis. It is also implicated in several pathological events like wound healing and cancer metastasis. Collective cell migration leads to the emergence of coordinated movements over multiple cells. Several of the previous studies have focused on the large-scale behavior of collectively migrating epithelia\, but the role of single cells in these migrating tissues during initiation of such coordinated collective migration was not investigated in detail. Also\, little attention was paid to the factors which could contribute towards the maintenance of such a robust and persistent migration process. In this study\, we implemented a minimalistic strategy using 1-Dimensional physical confinement set up to investigate the role of single cells in the emergence and the maintenance of these large-scale coordinated movements. Our data shows that the establishment of front-rear polarity and traction forces at the single cell level initiate the process of directed collective cell migration with the help of adherens junction. Once initiated\, a sustained memory of the single cell level polarity contributes towards the maintenance of collective cell migration for which the adherens junction are dispensable. \nUsing our in vitro 1D minimalistic assay\, we also investigated the emergence of collective behavior between two highly polarized interconnected migrating cell streams. We highlighted the role of the emergent collective migration dynamics present at the interfacial boundaries of migrating tissues in establishing distinct biomechanical and biochemical phenotypes. This work recapitulated some complex emergent behaviors like the convergent-extension dynamics observed during in vivo events of gastrulation. \nTogether\, this work demonstrates that the collective cell dynamics can arise from single cell behavior through a sustained memory of cell polarity and these strongly polarized migrating cohorts can further contribute towards the emergence of complex cellular mechanics between migrating tissues. \n  \n**Please note the examination following the seminar is closed-door** \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-emergence-of-coordinated-collective-cell-migration-under-physical-confinement-by-shreyansh-jain/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181204T093000
DTEND;TZID=Asia/Singapore:20181204T103000
DTSTAMP:20260419T200316
CREATED:20181128T020957Z
LAST-MODIFIED:20181128T021027Z
UID:25373-1543915800-1543919400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Structural-elastic determination of force-dependent transition rates of biomolecules by Guo Shiwen
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\,  4 December 2018\nVenue: Level 5 Seminar Room\, T-Lab \nStructural-elastic determination of force-dependent transition rates of biomolecules\nby Guo Shiwen\, PhD Student\, Yan Jie Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbispss-structural-elastic-determination-of-force-dependent-transition-rates-of-biomolecules-by-guo-shiwen/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181204T150000
DTEND;TZID=Asia/Singapore:20181204T160000
DTSTAMP:20260419T200316
CREATED:20181128T075435Z
LAST-MODIFIED:20181128T075435Z
UID:25422-1543935600-1543939200@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense:  Investigating the role of Desmosome and Intermediate Filaments in Apoptotic Cell Extrusion by Minnah Thomas
DESCRIPTION:MBI PhD Oral Defense\nTime: 3pm\nDate: Tuesday\, 4 December 2018\nVenue: MBI\, level 5 meeting rooms \nSupervisor: Prof Yusuke TOYAMA \nInvestigating the role of Desmosome and Intermediate Filaments in Apoptotic Cell Extrusion\nby Minnah THOMAS\, Toyama’s Group \nMechanical coupling of epithelia enables coordination of collective tissue movements during different developmental and physiological processes. During apoptosis in epithelia\, the dying cell is expelled by coordinated processes in both the dying cell and neighbours. Apoptotic cell extrusion is driven by both actomyosin cable constriction and lamellipodial crawling in the neighbours. Throughout cell extrusion\, mechanical coupling of epithelia needs to be maintained to preserve tissue homeostasis. Although much is known about the regulation of adherens junction during this process\, the role of desmosome junction (DJ) remains poorly understood. In this thesis\, we used a combination of laser based apoptosis induction and live confocal imaging in cultured epithelial monolayers to study DJs during extrusion. We show that DJ retains junctional coupling at the tissue interface throughout extrusion until formation of de novo junctions between apposing neighbours. The pre-existing DJ recruited radial cytokeratin-18 filaments and reoriented the keratin network during constriction. The DJ was proximate to the actomyosin cable at early constriction; and subsequently decoupled from the cable during its basolateral movement suggesting a mechanical coupling between the two. Molecular perturbation studies indicated that DJ is required to facilitate both constriction and de novo junction formation. We propose that desmosome influences junctional myosin driven tissue dynamics during extrusion. This study shows the pivotal role of desmosome in facilitating collective tissue dynamics to ensure epithelial sheet integrity during apoptotic cell extrusion. \n  \n**Please note the examination following the seminar is closed-door**
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-investigating-the-role-of-desmosome-and-intermediate-filaments-in-apoptotic-cell-extrusion-by-minnah-thomas/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181205
DTEND;VALUE=DATE:20181206
DTSTAMP:20260419T200316
CREATED:20181108T022249Z
LAST-MODIFIED:20181129T095232Z
UID:25296-1543968000-1544054399@www.mbi.nus.edu.sg
SUMMARY:MBI WIS: Finding the right path: How do multidomain proteins avoid misfolding and how can women avoid the pitfalls in their scientific career paths? by Jane Clarke
DESCRIPTION:Prof Clarke will be visiting MBI on December 5th\, 2018\, to give a seminar on her research and career. \nWhen: Wednesday\, December 5th\, 2018\nWhere: MBI Seminar Room\, Level 5\, T-Lab\nTime: TBA \nFinding the right path:  How do multidomain proteins avoid misfolding and how can women avoid the pitfalls in their scientific career paths?\nProteins have to fold to the correct structure if they are to function and avoid misfolding. Most eukaryotic proteins contain more than one independently folding domain. Since the local concentration of domains is high\, how do natural proteins avoid misfolding? \nAt least half of the students studying natural sciences in the early years at university are women\, and yet few make it to the top.  What can we do to avoid such a waste of talent? What can we do to ensure that women can enjoy what is the most satisfying of careers? \nClarke will show that nature\, through evolution\, has developed strategies that ensure that misfolding is rare.  Similarly\, she will show that we can develop both personal and institutional strategies to help women reach the top. \nLearn more about Prof Clarke
URL:https://www.mbi.nus.edu.sg/event/mbi-wis-finding-the-right-path-how-do-multidomain-proteins-avoid-misfolding-and-how-can-women-avoid-the-pitfalls-in-their-scientific-career-paths-by-jane-clarke/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI WIS
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181210
DTEND;VALUE=DATE:20181212
DTSTAMP:20260419T200316
CREATED:20181112T094114Z
LAST-MODIFIED:20181112T095305Z
UID:25325-1544400000-1544572799@www.mbi.nus.edu.sg
SUMMARY:MBI Graduate Programme Roadshow (On-Site Interview) at Bangalore\, India
DESCRIPTION:MBI Graduate Programme Roadshow (On-Site Interview) at Bangalore\, India\n10th – 11th December 2018\, Monday – Tuesday\n11:00 am – 05:00pm\nNational Centre for Biological Sciences\, Tata Institute of Fundamental Research\, GKVK\, Bellary Road\, Bangalore 560065\, India \nDirections: ncbs.res.in/contact-us \nTo sign up for the On-Site Interview\, please register with: mbigraduate@nus.edu.sg indicating your preferred date of interview by 3 December 2018. \nTransport allowance of up to INR2\,000 will be given to candidates traveling from outside Bangalore who register by 3 December 2018. \nCandidates are required to bring your CV and original transcripts/certificates for the interview. \nEmail enquiries to mbigraduate@nus.edu.sg\nWebsite: mbi.nus.edu.sg \nBrochure: mbi.nus.edu.sg/education/graduate-program/  \nWe look forward to seeing you at the Roadshow! \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-graduate-programme-roadshow-on-site-interview-at-bangalore-india/
LOCATION:National University of Singapore
CATEGORIES:MBI Graduate Recruitment Roadshow
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181212T160000
DTEND;TZID=Asia/Singapore:20181212T170000
DTSTAMP:20260419T200316
CREATED:20181206T020624Z
LAST-MODIFIED:20181206T020624Z
UID:25477-1544630400-1544634000@www.mbi.nus.edu.sg
SUMMARY:Mechanistic studies of stalled DNA replication fork rescue in Escherichia coli by Piero Bianco
DESCRIPTION:MBI Seminar\nWe are pleased to inform you on the seminar by A/Prof Piero Bianco\, hosted by Prof Yan Jie\, “Mechanistic studies of stalled DNA replication fork rescue in Escherichia coli” on 12 Dec (Wed) @4pm at T-Lab Level 5 Seminar Rooms.
URL:https://www.mbi.nus.edu.sg/event/mechanistic-studies-of-stalled-dna-replication-fork-rescue-in-escherichia-coli-by-piero-bianco/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
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