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X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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BEGIN:VTIMEZONE
TZID:Asia/Singapore
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:+08
DTSTART:20170101T000000
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TZID:Asia/Shanghai
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DTSTART:20170101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181102T093000
DTEND;TZID=Asia/Singapore:20181102T103000
DTSTAMP:20260422T040046
CREATED:20181101T020436Z
LAST-MODIFIED:20181101T020808Z
UID:25223-1541151000-1541154600@www.mbi.nus.edu.sg
SUMMARY:MBIw: Development of the MBI Pillar Tracker Microscope by Felix Margadant
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 2 November 2018\nVenue: Level 5 Seminar Room\, T-Lab \nDevelopment of the MBI Pillar Tracker Microscope\nby Felix Margadant\, Senior Research Fellow\, Sheetz Group \nBrief summary\nThis talk summarizes the road of development and the status quo of a prototype light microscope dedicated to the fast or long term tracking of force deflecting pillars with time parallel recording of fluorescent images. \nThe machine is an evolution from the early far-red low numerical aperture condensers which we built in order to avoid photo toxicity by using transmitted light of 635nm or longer wavelength. This tracking proved to be fast (157fps) and repeatable to better than 4nm. Specimen distortions limit the universality of the approach though\, and the focal plane cannot be stabilized which triggered the design of the presented system. \nThe talk addresses the problems with back reflected light\, image distortion\, and speed limitations of the current system.
URL:https://www.mbi.nus.edu.sg/event/mbiw-development-of-the-mbi-pillar-tracker-microscope-by-felix-margadant/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181106T130000
DTEND;TZID=Asia/Singapore:20181106T180000
DTSTAMP:20260422T040046
CREATED:20180924T090114Z
LAST-MODIFIED:20180925T043513Z
UID:24649-1541509200-1541527200@www.mbi.nus.edu.sg
SUMMARY:MBI 10th Anniversary Conference Satellite Meeting: Women in Science\, An afternoon of inspiration
DESCRIPTION:MECHANOBIOLOGY AFTER 10 YEARS: THE PROMISE OF MECHANOMEDICINE \nSatellite Meeting: Women in Science\, An afternoon of inspiration\nWomen in mechanobiology will come together from all over the world to celebrate their science\, discuss their journeys through academia and share their insights in navigating career challenges. Our speakers hail from seven countries and represent a range of academic experience. \nEach speaker will present a topic of her choice\, including but not limited to: challenges for women in science\, implicit bias in academia\, life/work balance\, and #Metoo in academia. A moderated panel discussion will follow highlighting cross-cultural strategies and formulating solutions for the future. \nDate: Tuesday\, November 6th\, 2018\nTime: 1pm-6pm\nVenue: Level 5\, T-Lab
URL:https://www.mbi.nus.edu.sg/event/mbi-10th-anniversary-conference-satellite-meeting-women-in-science-an-afternoon-of-inspiration/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:Conference,MBI WIS
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181107
DTEND;VALUE=DATE:20181111
DTSTAMP:20260422T040046
CREATED:20180427T043238Z
LAST-MODIFIED:20180627T033527Z
UID:22844-1541548800-1541894399@www.mbi.nus.edu.sg
SUMMARY:MBI 10th Anniversary Conference: Mechanobiology after 10 years: The promise of mechanomedicine
DESCRIPTION:The Mechanobiology Institute’s 10th Anniversary Conference\n “Mechanobiology after 10 Years: The Promise of Mechanomedicine”\nOrganized by\nMechanobiology Institute\, Singapore (MBI) \n7-10  November 2018 \nIn partnership with\nCNRS\, France\nThe National Centre for Biological Sciences\, India\nThe Weizmann Institute of Science\, Israel\nThe FIRC Institute of Molecular Oncology\, Italy \nAbout\nThe Mechanobiology Institute (MBI) at the National University of Singapore will be celebrating its 10th Anniversary in 2018. The field has grown significantly in the last ten years and mechanosensing and mechanotransduction are now common elements in the analysis of most cellular functions.  Mechanobiology is at the heart of cancer\, cardiovascular disease and the problems associated with aging.  In the area of wound healing\, mechanical stimulation is already a proven beneficial treatment.  A major challenge is whether or not we can move from phenomenology to molecular mechanisms that can be inhibited or accelerated to block further damage or improve healing.  Because targeted mechanical stimuli can alter biochemical processes in ways that drugs are meant to do but without long-lasting side effects\, they can be part of treatments.  However\, the targets of the mechanical stimuli and the downstream pathways involved should be understood to effectively design treatments.  Thus\, it is important to continue the interdisciplinary assault on Mechanobiology at a molecular level by using super-resolution microscopy and nanotechnology tools.  This conference is not to celebrate our successes but rather to start to define the areas where the understanding of mechanobiology can dramatically alter our approaches to fundamental biological problems in aging and disease. \nDates\n7-10 November 2018 \nVenue\nThe Shaw Foundation Alumni House\, National University of Singapore \nThemes\nIn line with this\, MBI’s 10th Anniversary Conference will be organized on the following themes : \n\nCancer Mechanobiology\nPathogenesis\nNeuro-degeneration\n3D Model Systems\nSingle molecule Mechanobiology\nMesoscale Mechanosensitivity\nTheoretical Mechanobiology\nEngineering Mechanobiology
URL:https://www.mbi.nus.edu.sg/event/mbi-10th-anniversary-conference-mechanobiology-after-10-years-the-promise-of-mechanomedicine/
LOCATION:National University of Singapore
CATEGORIES:Conference
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181110
DTEND;VALUE=DATE:20181112
DTSTAMP:20260422T040046
CREATED:20180424T035732Z
LAST-MODIFIED:20191212T034452Z
UID:22757-1541808000-1541980799@www.mbi.nus.edu.sg
SUMMARY:Mechanobiology International Graduate Student Congress 2018 (MBIGSC2018): Mechanomedicine
DESCRIPTION:  \nMBI Graduate students present the \nMechanobiology International Graduate Student Congress 2018\nWe are pleased to announce that the graduate students of MBI will be organizing the Mechanobiology International Graduate Student Congress (MBIGSC) 2018 themed “Mechanomedicine – MEDiating Forces”. This congress is in conjunction with MBI’s 10th anniversary conference in 2018\, Mechanobiology after 10 years: The promise of Mechanomedicine. \n  \nRegistration\nAbstracts are invited from current graduate students in Singapore and abroad working in Mechanobiology and related fields (click here). For participants interested in only attending please register here. \nRegistration fees: FREE\nAbstract deadline : 30th September\, 2018\nRegistration deadline : 28th October\, 2018 \nFind Out More \nOn behalf of the Organizing Committee\nZHANG Yue\nKapish GUPTA\nLIU Xuyao\nYOW Ying Ming\, Ivan\nSomsubhro MUKHERJEE\nFU Chaoyu\nLIU Chixuan\nDasvit SHETTY
URL:https://www.mbi.nus.edu.sg/event/mechanobiology-international-graduate-student-congress-2018-mbigsc2018-mechanomedicine/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:Conference,MBI Graduate Student Club
ATTACH;FMTTYPE=image/jpeg:https://www.mbi.nus.edu.sg/wp-content/uploads/2018/04/2018-11-MBI-grad-stu-congress-flyer-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181112
DTEND;VALUE=DATE:20181115
DTSTAMP:20260422T040046
CREATED:20180618T044005Z
LAST-MODIFIED:20180618T051514Z
UID:23359-1541980800-1542239999@www.mbi.nus.edu.sg
SUMMARY:Frontiers in Cancer Science 2018
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/frontiers-in-cancer-science-2018/
LOCATION:University Cultural Centre (UCC)\, 50 Kent Ridge Cres\, National University of Singapore\, Singapore\, 119279\, Singapore
CATEGORIES:CSI
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181113T093000
DTEND;TZID=Asia/Singapore:20181113T100000
DTSTAMP:20260422T040046
CREATED:20181112T045638Z
LAST-MODIFIED:20181112T045638Z
UID:25317-1542101400-1542103200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Unique Gene Expression Signatures of Mechano-Sensitive Transcription Co-Factors\, YAP and TAZ  by Lee Yaelim
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\,  13 November 2018\nVenue: Level 5 Seminar Room\, T-Lab \nUnique Gene Expression Signatures of Mechano-Sensitive Transcription Co-Factors\, YAP and TAZ\nby Lee Yaelim\, Research Fellow\, Sudol Group \nWhat happens to epithelia under small electric currents?\nby Saw Thuan Beng\, Alumni\, Research Fellow\, Lim Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-unique-gene-expression-signatures-of-mechano-sensitive-transcription-co-factors-yap-and-taz-by-lee-yaelim/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181113T100000
DTEND;TZID=Asia/Singapore:20181113T103000
DTSTAMP:20260422T040046
CREATED:20181112T045750Z
LAST-MODIFIED:20181112T045802Z
UID:25319-1542103200-1542105000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: What happens to epithelia under small electric currents? by Saw Thuan Beng
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\,  13 November 2018\nVenue: Level 5 Seminar Room\, T-Lab \nUnique Gene Expression Signatures of Mechano-Sensitive Transcription Co-Factors\, YAP and TAZ\nby Lee Yaelim\, Research Fellow\, Sudol Group \nWhat happens to epithelia under small electric currents?\nby Saw Thuan Beng\, Alumni\, Research Fellow\, Lim Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/what-happens-to-epithelia-under-small-electric-currents-by-saw-thuan-beng/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181114T183000
DTEND;TZID=Asia/Singapore:20181114T203000
DTSTAMP:20260422T040046
CREATED:20181114T062305Z
LAST-MODIFIED:20181114T062305Z
UID:25340-1542220200-1542227400@www.mbi.nus.edu.sg
SUMMARY:NUSS Professorship Lecture Series: My experience as a deep tech entrepreneur by Lim Chwee Teck
DESCRIPTION:Prof Lim Chwee Teck will be giving a talk at the NUSS Professorship Lecture Series\, about his experience as a deep tech entrepreneur. \nDate: 14 November 2018\, Wednesday\nTime: 630pm (registration & light refreshment provided)\, 7pm (seated) to 830pm\nVenue: NUSS Kent Ridge Guild House\, 9 Kent Ridge Drive SG 119241 \nRegister your attendance before 14 November 2018 as places are limited to a first come first serve basis.
URL:https://www.mbi.nus.edu.sg/event/nuss-professorship-lecture-series-my-experience-as-a-deep-tech-entrepreneur-by-lim-chwee-teck/
LOCATION:National University of Singapore
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181116T093000
DTEND;TZID=Asia/Singapore:20181116T103000
DTSTAMP:20260422T040046
CREATED:20181108T013244Z
LAST-MODIFIED:20181108T013345Z
UID:25289-1542360600-1542364200@www.mbi.nus.edu.sg
SUMMARY:MBIw: Molecular and cellular mechanisms mediating morphological symmetry and epithelial continuity during epithelial fusion by Maithreyi Narasimha
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 16 November 2018\nVenue: Level 5 Seminar Room\, T-Lab \nMolecular and cellular mechanisms mediating morphological symmetry and epithelial continuity during epithelial fusion\nby Professor Maithreyi Narasimha\, Department of Biological Sciences\, Tata Institute of Fundamental Research\, Mumbai\, INDIA
URL:https://www.mbi.nus.edu.sg/event/mbiw-molecular-and-cellular-mechanisms-mediating-morphological-symmetry-and-epithelial-continuity-during-epithelial-fusion-by-maithreyi-narasimha/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181119T160000
DTEND;TZID=Asia/Singapore:20181119T170000
DTSTAMP:20260422T040046
CREATED:20181115T025025Z
LAST-MODIFIED:20181115T025025Z
UID:25344-1542643200-1542646800@www.mbi.nus.edu.sg
SUMMARY:NGS PhD Oral Defense Series  Cell-substrate Adhesion and Cell-cell Junction Coordination in Epithelial Cell Extrusion by Le Anh Phuong
DESCRIPTION:NGS PhD Oral Defense Series\nCell-substrate Adhesion and Cell-cell Junction Coordination in Epithelial Cell Extrusion\nby Le Anh Phuong \nSupervisor(s): Prof Lim Chwee Teck\,  Prof Benoit Ladoux\nChairperson: A/Prof Low Boon Chuan \nDate / Time: 19 November 2018 at 4pm\nVenue: Meeting Room T203\, University Hall\, Tan Chin Tuan Wing\, 21 Lower Kent Ridge Road\, Level 2 \nPlease be present at least 10 mins prior to the start of Oral Defense and sign on the attendance sheet. Thank you for your kind consideration and cooperation. \nABSTRACT\nApoptotic extrusion is a coupled process when a cell undergoes apoptosis and actively removed from the epithelia. This process is crucial in maintaining epithelial homeostasis and has implications in diseases pertaining to epithelial tissues like cancer and asthma. Extrusion is mechanically-regulated when the neighboring cells could use either lamellipodia-based protrusion or contractile cable (purse-string) to actively remove the dying cells. The preference of one mode over another was found to be dependent on the density of the monolayer. However\, little is known about how much each of these two modes contribute to the overall effectiveness of extrusion\, and what determines one mode of extrusion over the other. The force arises during extrusion is poorly understood. Here we shown that during extrusion at highly packed tissue\, the formation of contractile actomyosin cables are anisotropic\, which is contradictory to previous belief that the actomyosin cable is formed in a uniform manner. Concurrently\, there were also lamellipodia-based protrusion observed. The existence of these two mechanisms results in an anisotropic force field surrounding extrusion site. By manipulating α-Catenin\, a mechano-sensing component of adherent junction\, we demonstrated that the reduced cell-cell junction favors the neighboring cells’ decision to form lamellipodia protrusion. On the other hand\, cells with strengthened cell-cell junction formed more actomyosin cable; the contractility was also enhanced to effectively extrude the dying cells when cell-substrate adhesion was removed. Our results highlighted the importance of previously-undermined lamellipodia-based protrusion in extrusion\, which ensures the complete closure during extrusion. We also demonstrated by tuning cell-cell junction strength of cell-substrate adhesion pattern\, we could control one mode over the other as well as the timing of actomyosin cable.
URL:https://www.mbi.nus.edu.sg/event/ngs-phd-oral-defense-series-cell-substrate-adhesion-and-cell-cell-junction-coordination-in-epithelial-cell-extrusion-by-le-anh-phuong/
LOCATION:National University of Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181120T093000
DTEND;TZID=Asia/Singapore:20181120T103000
DTSTAMP:20260422T040046
CREATED:20181113T063337Z
LAST-MODIFIED:20181113T063337Z
UID:25338-1542706200-1542709800@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Force dependence of filopodia adhesion by Naila Alieva
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\,  20 November 2018\nVenue: Level 5 Seminar Room\, T-Lab \nForce dependence of filopodia adhesion\nBy Naila Alieva\, Facility Manager\, Bershadsky Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-force-dependence-of-filopodia-adhesion-by-naila-alieva/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181121T140000
DTEND;TZID=Asia/Singapore:20181121T163000
DTSTAMP:20260422T040046
CREATED:20181015T092607Z
LAST-MODIFIED:20181112T093133Z
UID:25111-1542808800-1542817800@www.mbi.nus.edu.sg
SUMMARY:MBI Graduate Programme Open House
DESCRIPTION:The Mechanobiology Institute\, established in 2009\, is one of the world’s leading research institute in this field. \nWe would like to invite aspiring students (Science and Engineering) who are interested in academic training and research in Mechanobiology to join us at our Open House and: \n• Be inspired by the research conducted at the institute \n• Discover the cutting-technologies and facilities in super resolution microscopy and Life Sciences available to our researchers \n• Discuss your careers\, goals and dreams with our scientists and postgraduate students \n• Consider joining our MBI graduate programme as a fully-funded graduate scholar\n \nMBI Graduate Programme Open House\n21st Nov 2018\, Wednesday\n2:00pm to 4:30pm\n5A Engineering Drive 1\, T-Lab Building\, Level 5 Seminar Rooms\, Singapore 117411 \nTo sign up for the MBI Open House\, please click: tinyurl.com/registeropenhouse2018  (Please register early as places are limited.) \nEmail enquiries to mbigraduate@nus.edu.sg\nWebsite: mbi.nus.edu.sg\nBrochure: mbi.nus.edu.sg/education/graduate-program/  \nWe look forward to seeing you at the Open House! \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-graduate-programme-open-house-2/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Open House
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181123T093000
DTEND;TZID=Asia/Singapore:20181123T103000
DTSTAMP:20260422T040046
CREATED:20181120T045813Z
LAST-MODIFIED:20181120T045848Z
UID:25349-1542965400-1542969000@www.mbi.nus.edu.sg
SUMMARY:MBIw: Probing intracellular self-organization under geometric constraints using micro-compartments and micromanipulation by Ivo A Telley
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 23 November 2018\nVenue: Level 5 Seminar Room\, T-Lab \nProbing intracellular self-organization under geometric constraints using micro-compartments and micromanipulation\nBy Ivo A. Telley\, Instituto Gulbenkian de Ciência (IGC)\, Oeiras\, Portugal \n 
URL:https://www.mbi.nus.edu.sg/event/mbiw-probing-intracellular-self-organization-under-geometric-constraints-using-micro-compartments-and-micromanipulation-by-ivo-a-telley/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181127T093000
DTEND;TZID=Asia/Singapore:20181127T103000
DTSTAMP:20260422T040046
CREATED:20181127T011717Z
LAST-MODIFIED:20181127T013350Z
UID:25353-1543311000-1543314600@www.mbi.nus.edu.sg
SUMMARY:MBISPSS: Actomyosin dynamics couples extracellular signals to the mobility and molecular stability of telomeres by Doorgesh S Jokhun
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\,  27 November 2018\nVenue: Level 5 Seminar Room\, T-Lab \nActomyosin dynamics couples extracellular signals to the mobility and molecular stability of telomeres\nby Doorgesh S. Jokhun\, PhD Student\, Shivashankar Group \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/mbispss-actomyosin-dynamics-couples-extracellular-signals-to-the-mobility-and-molecular-stability-of-telomeres-by-doorgesh-s-jokhun/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181127T150000
DTEND;TZID=Asia/Singapore:20181127T160000
DTSTAMP:20260422T040046
CREATED:20181112T050337Z
LAST-MODIFIED:20181112T050337Z
UID:25322-1543330800-1543334400@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense: Dissecting the role of topographical cues in endothelialization process by Azita Gorji
DESCRIPTION:MBI PhD Oral Defense\nTime: 3pm\nDate: Tuesday\, 27 November 2018\nVenue: NUS Faculty of Engineering\, E4-04-03 \nSupervisors: Prof Pakorn Kanchanawong (Main supervisor) \nDissecting the role of topographical cues in endothelialization process\nby Azita GORJI\, Kanchanawong Group \nA major challenge in the treatment of cardiovascular disease is graft failure due to late endothelialization of small synthetic vascular grafts.  Although several biochemical and mechanical strategies have been applied to promote endothelialization of the graft surfaces\, enhancement of implant endothelialization has been limited. The integrity of Endothelial Cells (ECs) monolayer is crucial for endothelialization\, but the understanding of the crosstalk between surface modification and cell-cell connectivity is still limited.  Toward a more effective approach to enhance endothelialization\, in this thesis a combined strategy making use of both topographical features and biochemical perturbations was investigated. The effect of micron-scale anisotropic topography on ECs behaviors is analyzed in conjunction with pharmacological perturbations of EC junctions regulators. We identified a protein tyrosine phosphatase\, PTP1B\, as a potent regulator of ECs junction stability. Our results showed that PTP1B inhibition synergized with grating topographies to modulate EC adherens junction’s rearrangement resulting in global EC monolayer sheet orientation\, connectivity and migration. Our data suggest utilizing grating topographies and PTP1B inhibitor together as a possible platform to enhance endothelialization of vascular grafts. \n  \n**Please note the examination following the seminar is closed-door** \n  \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-dissecting-the-role-of-topographical-cues-in-endothelialization-process-by-azita-gorji/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181129T140000
DTEND;TZID=Asia/Singapore:20181129T150000
DTSTAMP:20260422T040046
CREATED:20181127T012627Z
LAST-MODIFIED:20181127T013554Z
UID:25358-1543500000-1543503600@www.mbi.nus.edu.sg
SUMMARY:Computational microscopy of dynamic order across biological scales by Shalin Mehta
DESCRIPTION:MBI Seminar\nWe are pleased to inform you of the seminar by Dr. Shalin Mehta\, hosted by Prof. Pakorn Tony Kanchanawong\, entitled Computational microscopy of dynamic order across biological scales on 29 November 2018 (Thursday) @ 2.00pm at T-Lab Level 5 Seminar Rooms. \n 
URL:https://www.mbi.nus.edu.sg/event/computational-microscopy-of-dynamic-order-across-biological-scales-by-shalin-mehta/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20181130T093000
DTEND;TZID=Asia/Singapore:20181130T103000
DTSTAMP:20260422T040046
CREATED:20181127T012339Z
LAST-MODIFIED:20181127T013701Z
UID:25355-1543570200-1543573800@www.mbi.nus.edu.sg
SUMMARY:MBIw: Engineering heterotypic cellular interactions for disease modeling and drug testing by Yi-Chin Toh
DESCRIPTION:MBI Seminar\nWe are pleased to inform you of the seminar by Prof Yi-Chin Toh\, hosted by Prof Virgile Viasnoff\, entitled Engineering heterotypic cellular interactions for disease modeling and drug testing on 30 November 2018 (Friday) @9.30am at T-Lab Level 5 Seminar Rooms. \n 
URL:https://www.mbi.nus.edu.sg/event/mbiw-engineering-heterotypic-cellular-interactions-for-disease-modeling-and-drug-testing-by-yi-chin-toh/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI Weekly Seminar
END:VEVENT
END:VCALENDAR