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X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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BEGIN:VTIMEZONE
TZID:Asia/Shanghai
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:CST
DTSTART:20170101T000000
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END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20180202T170000
DTEND;TZID=Asia/Shanghai:20180202T180000
DTSTAMP:20260409T084110
CREATED:20180119T032533Z
LAST-MODIFIED:20180119T032533Z
UID:21825-1517590800-1517594400@www.mbi.nus.edu.sg
SUMMARY:The actin-bundling protein plastin increases cortical connectivity to promote robust polarization and timely cytokinesis in early C. elegans embryogenesis by DING Wei Yung
DESCRIPTION:MBI PhD Oral Defense \nTime: 5pm\nDate: Friday\, 02 February 2018\nVenue: MBI\, level 5 meeting rooms \nSupervisors:  Prof Ronen Zaidel-Bar \nThe actin-bundling protein plastin increases cortical connectivity to promote robust polarization and timely cytokinesis in early C. elegans embryogenesis \nby DING Wei Yung\, Zaidel-Bar Group  \nMaintenance of the animal cell shape by the actomyosin cortex underlying the plasma membrane and generation of the contractile force within the cortex by non-muscle myosin II drive cellular morphogenetic processes such as gastrulation and cell division. Nevertheless\, the regulation of the architecture and dynamics of the cortex by actin-bundling proteins is still poorly understood. Here we demonstrate that the evolutionarily conserved actin-bundling protein plastin (a.k.a fimbrin) is instrumental for the generation of potent cortical actomyosin contractility in the C. elegans zygote. Endogenous plastin\, labelled by GFP via CRISPR/Cas9 knock-in\, was found to be associating with both formin- and arp2/3-mediated subpopulations of F-actin\, and enriched in contractile structures. Plastin was required for effective coalescence of nascent NMY-2 filaments into large contractile foci and for long-range coordinated contractility in the cortex. In the absence of plastin\, force-dependent cellular processes during early embryogenesis\, i.e. polarization and cytokinesis\, were both significantly compromised\, and 50% of embryos died during development. Based on these results as well as in silico CytoSim simulations\, we propose that by increasing the connectivity of the F-actin meshwork\, plastin enables the cortex to generate stronger and more coordinated forces to execute cellular morphogenesis. \n**Please note the examination following the seminar is closed-door**
URL:https://www.mbi.nus.edu.sg/event/the-actin-bundling-protein-plastin-increases-cortical-connectivity-to-promote-robust-polarization-and-timely-cytokinesis-in-early-c-elegans-embryogenesis-by-ding-wei-yung/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20180206T093000
DTEND;TZID=Asia/Shanghai:20180206T100000
DTSTAMP:20260409T084110
CREATED:20180124T033408Z
LAST-MODIFIED:20181005T080920Z
UID:21950-1517909400-1517911200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Structural organization in response to biomechanical properties of the environment at the single cell level by Richard De Mets
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.00am\nDate: Tuesday\, 6 February\, 2018\nVenue: Level 5 Seminar Room\, T-Lab \nStructural organization in response to biomechanical properties of the environment at the single cell level by Richard De Mets\, Research Fellow\, Viasnoff Group\n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you * \n 
URL:https://www.mbi.nus.edu.sg/event/structural-organization-in-response-to-biomechanical-properties-of-the-environment-at-the-single-cell-level-by-richard-de-mets-viasnoff-group/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20180206T100000
DTEND;TZID=Asia/Shanghai:20180206T103000
DTSTAMP:20260409T084111
CREATED:20180130T012039Z
LAST-MODIFIED:20181005T080901Z
UID:21980-1517911200-1517913000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Visualizing the dynamics and kinetics of Grb2/SOS on two RTK platforms shows the signal switching from one RTK to another: mass action model by Oh Dongmyung
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\, 6 February\, 2018\nVenue: Level 5 Seminar Room\, T-Lab \nVisualizing the dynamics and kinetics of Grb2/SOS on two RTK platforms shows the signal switching from one RTK to another: mass action model\nby Oh Dongmyung\, Research Fellow\, Sheetz Group \n\n* Please note this event is open to MBI researchers and invited guests only. Thank you * \n 
URL:https://www.mbi.nus.edu.sg/event/visualizing-the-dynamics-and-kinetics-of-grb2-sos-on-two-rtk-platforms-shows-the-signal-switching-from-one-rtk-to-another-mass-action-model-by-oh-dongmyung/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20180221T110000
DTEND;TZID=Asia/Shanghai:20180221T120000
DTSTAMP:20260409T084111
CREATED:20180214T013934Z
LAST-MODIFIED:20180214T013934Z
UID:22037-1519210800-1519214400@www.mbi.nus.edu.sg
SUMMARY:BCH domain as a versatile scaffold protein module and a key p(l)acemaker in cell signaling: a journey through space and time by Prof Low Boon Chuan
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/bch-domain-as-a-versatile-scaffold-protein-module-and-a-key-placemaker-in-cell-signaling-a-journey-through-space-and-time-by-prof-low-boon-chuan/
LOCATION:DBS Conference Room 1\, 14 Science Drive 4\, Singapore\, 117543\, Singapore
CATEGORIES:DBS Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20180222T110000
DTEND;TZID=Asia/Shanghai:20180222T120000
DTSTAMP:20260409T084111
CREATED:20180214T013556Z
LAST-MODIFIED:20180221T022512Z
UID:22035-1519297200-1519300800@www.mbi.nus.edu.sg
SUMMARY:How mycobacterial phenolic glycolipid subvert host macrophages: a general case and a special case by Prof Lalita Ramakrishnan
DESCRIPTION:We are extremely pleased to announce that Prof Lalita Ramakrishnan\, Professor of Immunology and Infectious Diseases\, University of Cambridge\, will be giving a talk on ‘How mycobacterial phenolic glycolipid subvert host macrophages: a general case and a special case’ on Thursday\, 22nd February\, at 11am\, Level 5 meeting rooms.
URL:https://www.mbi.nus.edu.sg/event/how-mycobacterial-phenolic-glycolipid-subvert-host-macrophages-a-general-case-and-a-special-case-by-prof-lalita-ramakrishnan/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20180223T093000
DTEND;TZID=Asia/Shanghai:20180223T103000
DTSTAMP:20260409T084111
CREATED:20180220T045727Z
LAST-MODIFIED:20181005T080839Z
UID:22045-1519378200-1519381800@www.mbi.nus.edu.sg
SUMMARY:MBIw: Apoptotic cell extrusion update by Prof Yusuke Toyama
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 23 February 2018\nVenue: Level 5 Seminar Room\, T-Lab \nApoptotic cell extrusion update\nby Prof Yusuke Toyama\, Principal Investigator\, MBI
URL:https://www.mbi.nus.edu.sg/event/apoptotic-cell-extrusion-update-by-prof-yusuke-toyama/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180226
DTEND;VALUE=DATE:20180301
DTSTAMP:20260409T084111
CREATED:20170828T092111Z
LAST-MODIFIED:20171124T034009Z
UID:20489-1519603200-1519862399@www.mbi.nus.edu.sg
SUMMARY:Joint NUS-HU Workshop on Patterning and Timing in Development and Evolution
DESCRIPTION:Joint NUS-HU Workshop on Patterning and Timing in Development and Evolution\nHumboldt University\, Berlin\, Germany\n26th-28th of February 2018\nEmbryonic development represents a balancing act between robustness and evolvability. For individual organisms\, developmental processes must be robust to environmental fluctuations and the influence of segregating mutations. But at the same time\, development must be able to evolve if populations are to adapt. Understanding this interplay requires the integration of genetic and evolutionary approaches\, a physical understanding of how the embryo develops\, and modern methods for assessing developmental phenotypes (from developmental rate to embryonic shape to developmental gene expression profiles). \nRecently\, there has been increasing interest in the importance of temporal regulation during development. How such temporal regulation emerged and how it is controlled at a molecular level are still poorly understood. We aim to bring together a broad range of research interests – from evolution to timing to cell biology – to build potential collaborations to tackle this intriguing problem. \nDates: 26th-28th of February 2018\nWhere: Humboldt University\, Berlin\, Germany \n  \nInvited Speakers\n\n\n\nNational University of Singapore\n\n\nGregory Jedd\nTemasek Lifesciences Laboratory\n\n\nAntonia Monteiro\nYale-NUS College\n\n\nNick Tolwinski\nYale-NUS College\n\n\nHongyan Wang\nDuke-NUS\n\n\nYusuke Toyama\nMechanobiology Institute\, NUS (MBI)\n\n\n\n  \n\n\n\nHumboldt University\, Berlin\n\n\nHans Peter Herzel\n Institute for Theoretical Biology\n\n\nKerstin Kaufmann\n Institute for Biology\n\n\nJan Philipp Junker\n Max Delbruck Center for Molecular Medicine\n\n\nLeonie Ringrose\n IRI Life Sciences\n\n\nRobert Zinzen\n Max Delbruck Center for Molecular Medicine\n\n\n\n  \n\n\n\nOthers\n\n\nAlexander Aulehla\nEuropean Molecular Biology Laboratory (EMBL)\n\n\nBart Deplancke\n Swiss Institute of Bioinformatics\n\n\nMounia Lagha\n Institut Génétique Molécuaire Montpellier\n\n\n\n  \n  \nRegistration\nRegistration in the Joint NUS-HU Workshop on Patterning and Timing in Development and Evolution is free and open to all interested researchers. To apply for a space please contact Timothy Saunders\, Assistant Professor\, Mechanobiology Institute. We must receive your registration request by December 20th\, 2017. \nThere will be opportunities for attendees to present their work. If you wish to give a talk\, please provide an abstract (<300 words) to Timothy Saunders by the above deadline. \n  \n  \nAccommodation\nThe Humboldt University guesthouse\, located in the Ziegelstraße 13a\, 10117 Berlin\, offers overnight accommodation in a central location for staff and guests of the university. More information. \nNearby Hotels\nHotel Berlin Mitte by Campanile\, Invalidenstr. 98\, 10115\nwww.nordic-hotels.com/hotels/hotel-berlin-mitte-by-campanile-frueher-nordic/ \nCalma Berlin Mitte\, Linienstr. 139-140\, 10115\nlindemannhotels.de/hotel-berlin/calma-berlin-mitte/ \nGenerator\, Oranienburger Strasse 65\,  10117\ngeneratorhostels.com/destinations/berlin/mitte \nMEININGER Hotel Berlin Mitte “Humboldthaus” Oranienburger Straße 67/68\, 10117 Berlin\nwww.meininger-hotels.com/en/hotels/berlin/center/ \n  \n  \nOrganizers\nTimothy Saunders\, Assistant Professor\, Mechanobiology Institute\, National University of Singapore \nDavid Garfield\, Independent Junior Group Leader\, IRI Life Sciences\, Department of Biology\, Humboldt-Universität\, Berlin \n  \n  \nSupported by\nHumboldt University and NUS are connected through several strong and long existing cooperations between researchers in various disciplines. Similarities between both universities in structure\, size and research focus offer many opportunities for further research collaborations. \nBoth universities commit resources to take existing ties and cooperative projects to a next level as well as to encompass additional disciplinary areas and types of activity. Each university contributes 150\,000 EUR per year to a budget that is dedicated to supporting activities within the partnership. Learn more.
URL:https://www.mbi.nus.edu.sg/event/joint-nus-hu-workshop-on-patterning-and-timing-in-development-and-evolution/
LOCATION:National University of Singapore
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20180227T093000
DTEND;TZID=Asia/Shanghai:20180227T103000
DTSTAMP:20260409T084111
CREATED:20180221T082854Z
LAST-MODIFIED:20181005T080952Z
UID:22068-1519723800-1519727400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: The emergence of leader cells in epithelial layers by Dr Hayri Emrah Balcioglu
DESCRIPTION:MBI Student and Postdoc Seminar Series (SPSS)\nTime: 9.30am-10.30am\nDate: Tuesday\, 27 February\, 2018\nVenue: Level 5 Seminar Room\, T-Lab \nThe emergence of leader cells in epithelial layers\nby Dr. Hayri Emrah Balcioglu\, Research Fellow\, Ladoux’s Group \n  \n  \n* Please note this event is open to MBI researchers and invited guests only. Thank you *
URL:https://www.mbi.nus.edu.sg/event/the-emergence-of-leader-cells-in-epithelial-layers-by-dr-hayri-emrah-balcioglu/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
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