BEGIN:VCALENDAR
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PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Shanghai
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:CST
DTSTART:20160101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170704T093000
DTEND;TZID=Asia/Shanghai:20170704T100000
DTSTAMP:20260625T165016
CREATED:20170630T014339Z
LAST-MODIFIED:20170630T014339Z
UID:19856-1499160600-1499162400@www.mbi.nus.edu.sg
SUMMARY:Development of a Skin-on-Chip by Supatra Tharinee Marsh
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 4 July at Level 5 Seminar Room. \nPresenter 1: Supatra Tharinee Marsh\nTalk Title: Development of a Skin-on-Chip \nPresenter 2: Lakshmi Ramachandran \nTalk Title: Glimpses from the Gender Summit 10: ‘Better Research and Innovation through Diversity and Gender Equality (BRIDGE) \n 
URL:https://www.mbi.nus.edu.sg/event/development-of-a-skin-on-chip-by-supatra-tharinee-marsh/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170704T100000
DTEND;TZID=Asia/Shanghai:20170704T103000
DTSTAMP:20260625T165016
CREATED:20170630T014454Z
LAST-MODIFIED:20170630T014454Z
UID:19858-1499162400-1499164200@www.mbi.nus.edu.sg
SUMMARY:Glimpses from the Gender Summit 10: 'Better Research and Innovation through Diversity and Gender Equality (BRIDGE)' by Lakshmi Ramachandran
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 4 July at Level 5 Seminar Room. \nPresenter 1: Supatra Tharinee Marsh\nTalk Title: Development of a Skin-on-Chip \nPresenter 2: Lakshmi Ramachandran\nTalk Title: Glimpses from the Gender Summit 10: ‘Better Research and Innovation through Diversity and Gender Equality (BRIDGE)’ \n 
URL:https://www.mbi.nus.edu.sg/event/glimpses-from-the-gender-summit-10-better-research-and-innovation-through-diversity-and-gender-equality-bridge-by-lakshmi-ramachandran/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170704T150000
DTEND;TZID=Asia/Shanghai:20170704T160000
DTSTAMP:20260625T165016
CREATED:20170627T015301Z
LAST-MODIFIED:20170627T015301Z
UID:19781-1499180400-1499184000@www.mbi.nus.edu.sg
SUMMARY:Reorganization of the intracellular architecture by mechanical forces at multiple scales by Dr Maxim Molodtsov
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/reorganization-of-the-intracellular-architecture-by-mechanical-forces-at-multiple-scales-by-dr-maxim-molodtsov/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170707T163000
DTEND;TZID=Asia/Shanghai:20170707T173000
DTSTAMP:20260625T165016
CREATED:20170706T065226Z
LAST-MODIFIED:20170706T065226Z
UID:19933-1499445000-1499448600@www.mbi.nus.edu.sg
SUMMARY:PhD Oral Defense: Role of topographic cues on cancer cell proliferation by Parthiv Kant CHAUDHURI
DESCRIPTION:Role of topographic cues on cancer cell proliferation\nSpeaker: Parthiv Kant CHAUDHURI (Graduate Student\, MBI\, NUS)\nDate: 7 Jul 2017\, Friday\nTime: 4:30pm\nVenue: MBI\, T-lab\, level 5 seminar rooms \nSupervisor(s): Prof LIM Chwee Teck (main supervisor)\, A/P LOW Boon Chuan (co-supervisor) \nAbstract: Metastasis from a primary epithelial tumor is one of the main causes of cancer related deaths. While the roles of biochemical cues on the metastatic cascade are well known\, mounting evidences suggest that physical cues such as extracellular matrix (ECM) stiffness\, dimensionality and topography also direct cancer cell behaviour. Although the role of stiffness on proliferative response of cancer cells has been well studied\, little is known about the effect of topographic cues in guiding cancer cell proliferation. \nHere\, we examined the effect of topographic cues on cancer cell proliferation by fabricating micron scale topographic features. Firstly\, we studied the role of topographic cues of the primary breast tumor microenvironment in influencing proliferation. We observed that the proliferation response of non-cancer breast epithelial cells (MCF-10A) but not of metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cells; decreases on the microgratings (gratings widths of 2\, 3 and 4 μm) across all the ECM proteins\, namely\, fibronectin\, collagen and laminin. However\, isotropic features such as micropillars do not reduce the proliferation of MCF-10A\, indicating that the anisotropic environmental cues are essential for this process. Interestingly\, micrograting mediated reduction of proliferation is prevented in the presence of acto-myosin contraction inhibitory drugs\, namely\, Y-27632 and blebbistatin\, thereby confirming the activation of Rho-ROCK-Myosin in this phenomenon. Beside the primary breast tumor microenvironment\, we also focused on the role of the topographic cues that mimicked the secondary breast tumor microenvironment. Bone\, which is composed of a porous matrix\, is one of the principal secondary locations for breast cancer. However\, little is known about the effect of this porous microenvironment in regulating cancer cell proliferation. Here\, we examined how the depth of the pores could transduce a mechanical signal and reduce the proliferation of non-cancer and malignant breast cancer cells. Interestingly\, cells extended actin-rich protrusions\, such as invadopodia to sense the depth of the matrix pore and activate actomyosin contractility to decrease MCF-10A proliferation. However\, in MDA-MB-231\, depth sensing inactivates Rho-Rac regulated actomyosin contractility and phospho-ERK signaling. Inhibiting contractility on this porous matrix using blebbistatin further reduced MDA-MB-231 proliferation. Taken together\, we observe the existence of Mechanically Induced Dormancy (MID) where topographical cues could inhibit the proliferation of non-cancer and malignant breast cancer cells through differential regulation of actomyosin contractility. \nALL EXCEPT PANEL ARE EXCUSED FOR CLOSE DOOR EXAMINATION
URL:https://www.mbi.nus.edu.sg/event/phd-oral-defense-role-of-topographic-cues-on-cancer-cell-proliferation-by-parthiv-kant-chaudhuri/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170707T173000
DTEND;TZID=Asia/Shanghai:20170707T190000
DTSTAMP:20260625T165016
CREATED:20170703T015120Z
LAST-MODIFIED:20170703T015153Z
UID:19887-1499448600-1499454000@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Class of 2017 Graduation Dinner hosted by Prof Sheetz
DESCRIPTION:MBI celebrates the graduation of the MBI PhD Class of 2017 with a dinner reception hosted by Prof. Michael Sheetz. \nDate: 7 July 2017\, Friday\nTime: 5:30pm\nVenue: T-Lab Level 10 Foyer \nProf. Sheetz especially invites the family and parents of this year’s graduates to join us. We hope to see you all on Friday\, 7 July.
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-class-of-2017-graduation-dinner-hosted-by-prof-sheetz/
LOCATION:National University of Singapore
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170711T093000
DTEND;TZID=Asia/Shanghai:20170711T100000
DTSTAMP:20260625T165016
CREATED:20170706T070000Z
LAST-MODIFIED:20170706T070000Z
UID:19939-1499765400-1499767200@www.mbi.nus.edu.sg
SUMMARY:Left-right asymmetry determination in single cell and cell group by Tee Yee Han
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 11 July at Level 5 Seminar Room. \nPresenter 1: Tee Yee Han\nTalk Title: Left-right asymmetry determination in single cell and cell group \nPresenter 2:  Zhang Zhen\nTalk Title: ImaEdge: a platform for the quantitative analysis of cortical proteins spatiotemporal dynamics during cell polarization \n 
URL:https://www.mbi.nus.edu.sg/event/left-right-asymmetry-determination-in-single-cell-and-cell-group-by-tee-yee-han/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170711T100000
DTEND;TZID=Asia/Shanghai:20170711T103000
DTSTAMP:20260625T165016
CREATED:20170706T070109Z
LAST-MODIFIED:20170706T070109Z
UID:19941-1499767200-1499769000@www.mbi.nus.edu.sg
SUMMARY:ImaEdge: a platform for the quantitative analysis of cortical proteins spatiotemporal dynamics during cell polarization by Zhang Zhen
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 11 July at Level 5 Seminar Room. \nPresenter 1: Tee Yee Han\nTalk Title: Left-right asymmetry determination in single cell and cell group \nPresenter 2:  Zhang Zhen\nTalk Title: ImaEdge: a platform for the quantitative analysis of cortical proteins spatiotemporal dynamics during cell polarization \n 
URL:https://www.mbi.nus.edu.sg/event/imaedge-a-platform-for-the-quantitative-analysis-of-cortical-proteins-spatiotemporal-dynamics-during-cell-polarization-by-zhang-zhen/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170712T160000
DTEND;TZID=Asia/Shanghai:20170712T170000
DTSTAMP:20260625T165016
CREATED:20170704T012324Z
LAST-MODIFIED:20170704T012324Z
UID:19925-1499875200-1499878800@www.mbi.nus.edu.sg
SUMMARY:Understanding biological phenomena from the mechanics aspects by Prof Chen Bin
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/understanding-biological-phenomena-from-the-mechanics-aspects-by-prof-chen-bin/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170714T093000
DTEND;TZID=Asia/Shanghai:20170714T103000
DTSTAMP:20260625T165016
CREATED:20170712T053515Z
LAST-MODIFIED:20170712T053515Z
UID:19955-1500024600-1500028200@www.mbi.nus.edu.sg
SUMMARY:MBI Junior Scientists Group: My journey towards independence in Academia: Dr Huijuan You and Dr Yusuke Hara
DESCRIPTION:Dear all\, \nWe are pleased to announce inspirational career talks from two of our MBI postdocs\, Dr. Huijuan You and Dr. Yusuke Hara\, who have recently secured independent positions in Academia. \nTopic: ‘My journey towards independence in Academia’ \nSpeakers: Dr. Huijuan You and Dr. Yusuke Hara \nDate: Friday\, 14th July 2017 \nTime: 9.30am \nVenue: Level 5 seminar rooms\, T-Labs \nLet us hear their experiences and gain important pointers for career progression! \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-junior-scientists-group-my-journey-towards-independence-in-academia-dr-huijuan-you-and-dr-yusuke-hara/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Career Committee,MBI WIS
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170725T160000
DTEND;TZID=Asia/Shanghai:20170725T170000
DTSTAMP:20260625T165016
CREATED:20170712T054230Z
LAST-MODIFIED:20170712T054230Z
UID:19957-1500998400-1501002000@www.mbi.nus.edu.sg
SUMMARY:Modulating Stem Cell Differentiation Via Cell-Material Interaction by Dr Ajay Tijore
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/modulating-stem-cell-differentiation-via-cell-material-interaction-by-dr-ajay-tijore/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170725T160000
DTEND;TZID=Asia/Shanghai:20170725T170000
DTSTAMP:20260625T165016
CREATED:20170726T022140Z
LAST-MODIFIED:20170726T022140Z
UID:20015-1500998400-1501002000@www.mbi.nus.edu.sg
SUMMARY:Modulating Stem Cell Differentiation Via Cell-Material Interaction by Dr Ajay Tijore
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/modulating-stem-cell-differentiation-via-cell-material-interaction-by-dr-ajay-tijore-2/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
END:VCALENDAR