BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Shanghai
BEGIN:STANDARD
TZOFFSETFROM:+0800
TZOFFSETTO:+0800
TZNAME:CST
DTSTART:20150101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;VALUE=DATE:20161204
DTEND;VALUE=DATE:20170109
DTSTAMP:20260629T001918
CREATED:20161221T014750Z
LAST-MODIFIED:20161221T014750Z
UID:16444-1480809600-1483919999@www.mbi.nus.edu.sg
SUMMARY:NUS Academic Calendar: Semester break
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/nus-academic-calendar-semester-break/
LOCATION:National University of Singapore
CATEGORIES:NUS Academic Calendar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170106T160000
DTEND;TZID=Asia/Shanghai:20170106T170000
DTSTAMP:20260629T001918
CREATED:20170105T023323Z
LAST-MODIFIED:20170105T023323Z
UID:16458-1483718400-1483722000@www.mbi.nus.edu.sg
SUMMARY:Biology Colloquium: Sociomicrobiology: Quorum Sensing\, Cooperation and Conflict in Populations of the Opportunistic Pathogen Pseudomonas Aeruginosa
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/biology-colloquium-sociomicrobiology-quorum-sensing-cooperation-and-conflict-in-populations-of-the-opportunistic-pathogen-pseudomonas-aeruginosa/
LOCATION:DBS Conference Room 1\, 14 Science Drive 4\, Singapore\, 117543\, Singapore
CATEGORIES:Biology Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170109T140000
DTEND;TZID=Asia/Shanghai:20170109T170000
DTSTAMP:20260629T001918
CREATED:20161221T020657Z
LAST-MODIFIED:20161221T021055Z
UID:16446-1483970400-1483981200@www.mbi.nus.edu.sg
SUMMARY:MBI Open House
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/mechanobiology-institute-2017-open-house/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170110T120000
DTEND;TZID=Asia/Shanghai:20170110T130000
DTSTAMP:20260629T001918
CREATED:20170105T040617Z
LAST-MODIFIED:20170105T040617Z
UID:16470-1484049600-1484053200@www.mbi.nus.edu.sg
SUMMARY:Salmonella to Fight Cancer--Turning a Foe into a Friend by Dr Siegfried Weiss
DESCRIPTION:I am pleased to inform you on the seminar by Dr. Siegfried Weiss\, Institute of Immunology\, Hannover Medical School\, Hannover\, Germany hosted by Prof. Linda Kenney\, 10 January 2017 at 12pm\, at T-Lab Level 5 Seminar Rooms. \nTitle: Salmonella to fight cancer – turning a foe into a friend \nSpeaker: Dr. Siegfried Weiss\, Institute of Immunology\, Hannover Medical School\, Hannover\, Germany \nDate: Tuesday\, 10 January 2017\nTime: 12.00pm\nVenue: Level 5 seminar rooms\, T-Lab
URL:https://www.mbi.nus.edu.sg/event/salmonella-to-fight-cancer-turning-a-foe-into-a-friend-by-dr-siegfried-weiss/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170112T090000
DTEND;TZID=Asia/Shanghai:20170112T160000
DTSTAMP:20260629T001918
CREATED:20170105T022456Z
LAST-MODIFIED:20170105T022456Z
UID:16452-1484211600-1484236800@www.mbi.nus.edu.sg
SUMMARY:Special IBN Symposium\, Biopolis
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/special-ibn-symposium-biopolis/
LOCATION:National University of Singapore
CATEGORIES:A*STAR Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170112T100000
DTEND;TZID=Asia/Shanghai:20170112T110000
DTSTAMP:20260629T001918
CREATED:20170110T091003Z
LAST-MODIFIED:20170110T091128Z
UID:16482-1484215200-1484218800@www.mbi.nus.edu.sg
SUMMARY:Recruitment of Vinculin During Talin Stretching by Hu Xian Edna
DESCRIPTION:Speaker: HU Xian\, Edna (Graduate Student\, MBI\, NUS)\nDate: 12 January 2017\, Thursday\nTime: 10am\nVenue: MBI\, T-lab\, level 5 seminar rooms\nSupervisor(s):  Prof Michael Sheetz and Prof Alexander Bershadsky \nAbstract: Talin is a critical focal adhesion adaptor protein that connects actin and integrin directly. Talin dimer has up to 22 cryptic vinculin binding sites (VBS) that are exposed by stretching. A method was developed to dynamically measure both the length of talin and the binding of vinculin at a superresolution level in live cells. Unlike many models of the talin dimer\, talin N-termini(integrin-binding domain) are sperated by about 180nm\, whereas the C-terminal dimerization domains colocalize. The rapid stretching and relaxation cycles of the talin dimers occurs majority in peripheral cell regions\, with a direction that agrees with actin flow. This is consistent with a stick-slip model for transient binding to flowing actin. By tagging a vinculin-dihydrofaolate reductase(DHFR) chimera with a covalent fluorophore(TMP-atto655). Vinculin binding to talin was monitored in parallel with talin length. A peak of binding was found at the length of 180nm for both full-length vinculin and vinculin head domain\, but controls didn’t bind. Surprisingly\, multiple vinculins bound within a single second in narrowly localized regions of the talin rod during stretching. Thus we suggest that talin stretching activates vinculin binding in a cooperative manner\, consistent with vinculin dynamics in vivo. \nALL EXCEPT PANEL ARE EXCUSED FOR CLOSE DOOR EXAMINATION
URL:https://www.mbi.nus.edu.sg/event/recruitment-of-vinculin-during-talin-stretching-by-hu-xian-edna/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170113T093000
DTEND;TZID=Asia/Shanghai:20170113T223000
DTSTAMP:20260629T001918
CREATED:20170105T073603Z
LAST-MODIFIED:20170105T074131Z
UID:16472-1484299800-1484346600@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar: How Cell-Cell Adhesion Molecules Shape Nanoscale Glutamate Receptor Organization and Excitatory Synaptic Function by Dr Daniel Choquet
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-how-cell-cell-adhesion-molecules-shape-nanoscale-glutamate-receptor-organization-and-excitatory-synaptic-function/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170113T160000
DTEND;TZID=Asia/Shanghai:20170113T170000
DTSTAMP:20260629T001918
CREATED:20170110T034726Z
LAST-MODIFIED:20170110T034741Z
UID:16479-1484323200-1484326800@www.mbi.nus.edu.sg
SUMMARY:MBI Career Talk: Dr Utkur Mirsaidov\, Assistant Professor from the Department of Physics\, National University of Singapore
DESCRIPTION:We are pleased to announce a Career talk by Dr. Utkur Mirsaidov\, Assistant Professor from the Department of Physics\, National University of Singapore\, Singapore. Dr. Mirsaidov was a research fellow at MBI (Dr. Paul Matsudaira’s group) who successfully secured a principal investigator position at the Department of Physics in 2014. \nPlease visit his website for more information: http://www.mirsaidov.org/ \nIn this seminar\, he will present his team’s current research work and follow it up with an informal discussion on his journey in the Academic world. \nSpeaker: Dr. Utkur Mirsaidov\, Department of Physics\, NUS\nDate: Friday\, 13th January 2017\nTime: 4pm\nVenue: Level 5 seminar rooms\, T-Lab \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-career-talk-dr-utkur-mirsaidov-assistant-professor-from-the-department-of-physics-national-university-of-singapore/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Career Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170116T080000
DTEND;TZID=Asia/Shanghai:20170116T173000
DTSTAMP:20260629T001918
CREATED:20170105T030447Z
LAST-MODIFIED:20170105T030928Z
UID:16465-1484553600-1484587800@www.mbi.nus.edu.sg
SUMMARY:SMART BioSystems & Micromechanics: Cell Advanced Manufacturing and Production
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/smart-biosystems-micromechanics-cell-advanced-manufacturing-and-production/
LOCATION:CREATE Tower\, NUS University Town\, 1 Create Way\, Singapore\, 138602\, Singapore
CATEGORIES:SMART BioSystems and Micromechanics
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170117T093000
DTEND;TZID=Asia/Shanghai:20170117T100000
DTSTAMP:20260629T001918
CREATED:20170112T014931Z
LAST-MODIFIED:20170112T014931Z
UID:16485-1484645400-1484647200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Cell-Cell Junctional Regulation under Stress – Investigated via Cell Junction Mechanical Stimulator by Gao Xumei
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 17 January at Level 5 Seminar Room. \nPresenter 1: Yao Mingxi\nTalk Title: To be advised \nPresenter 2: Gao Xumei\nTalk Title: Cell-Cell Junctional Regulation under Stress – Investigated via Cell Junction Mechanical Stimulator
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-cell-cell-junctional-regulation-under-stress-investigated-via-cell-junction-mechanical-stimulator-by-gao-xumei/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170117T093000
DTEND;TZID=Asia/Shanghai:20170117T103000
DTSTAMP:20260629T001918
CREATED:20170117T015726Z
LAST-MODIFIED:20170117T015726Z
UID:16498-1484645400-1484649000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Molecular Mechanisms of Mechanosensing by Yao Mingxi
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 17 January at Level 5 Seminar Room. \nPresenter : Yao Mingxi\nTalk Title: Molecular Mechanisms of Mechanosensing \nPresenter 2:  Gao Xumei\nTalk Title: Cell-Cell Junctional Regulation under Stress – Investigated via Cell Junction Mechanical Stimulator \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-molecular-mechanisms-of-mechanosensing-by-yao-mingxi/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170117T150000
DTEND;TZID=Asia/Shanghai:20170117T160000
DTSTAMP:20260629T001918
CREATED:20170110T025338Z
LAST-MODIFIED:20170110T025338Z
UID:16476-1484665200-1484668800@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar: Understanding Dynamics and Molecular Interactions in Lipid Bilayer\, DNA and Microemulsion Droplets using Femtosecond and Single Molecule Spectroscopy by Dr Moirangthem Kiran Singh
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-understanding-dynamics-and-molecular-interactions-in-lipid-bilayer-dna-and-microemulsion-droplets-using-femtosecond-and-single-molecule-spectroscopy-by-dr-moirangthem-kiran-singh/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170119T144500
DTEND;TZID=Asia/Shanghai:20170119T154500
DTSTAMP:20260629T001918
CREATED:20170117T015029Z
LAST-MODIFIED:20170117T015029Z
UID:16494-1484837100-1484840700@www.mbi.nus.edu.sg
SUMMARY:MBI Outreach: High School Student Lab Tour
DESCRIPTION:MBI is hosting a group of 10 high school students as part of an outreach activity this Thursday\, the 19th of January. \nThey will be touring MBI labs between 2:45pm to3:45pm\, prior to which they will attend a talk on Mechanobiology at L10 lobby. \nAs this is a really small group\, we hope that the the lab tours would not cause any disruption to normal lab activities. However\, please plan your experiments with this in mind and thank you for your understanding.We would appreciate your cooperation in the smooth progress of the lab demos and in keeping the L10 lobby area free from 2pm to 2:45pm.  
URL:https://www.mbi.nus.edu.sg/event/mbi-outreach-high-school-student-lab-tour/
LOCATION:National University of Singapore
CATEGORIES:Outreach Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170119T150000
DTEND;TZID=Asia/Shanghai:20170119T160000
DTSTAMP:20260629T001918
CREATED:20161216T020222Z
LAST-MODIFIED:20161216T020222Z
UID:16439-1484838000-1484841600@www.mbi.nus.edu.sg
SUMMARY:BIGHEART: Clinical Value of Pulsed Magnetic Fields by Professor Luke P Lee
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/bigheart-clinical-value-of-pulsed-magnetic-fields-by-professor-luke-p-lee/
LOCATION:BIGHEART Seminar\, CeLS Seminar Room 1\, Singapore\, 117456\, Singapore
CATEGORIES:Biomedical Institute for Global Health Research & Technology (BIGHEART)
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170119T160000
DTEND;TZID=Asia/Shanghai:20170119T170000
DTSTAMP:20260629T001918
CREATED:20170117T015426Z
LAST-MODIFIED:20170117T015426Z
UID:16496-1484841600-1484845200@www.mbi.nus.edu.sg
SUMMARY:PhD Oral Defense: Signaling and Mechanical Regulation of Podosome-Type Cell-Matrix Adhesions by Nisha Mohd Rafiq
DESCRIPTION:Department of Biological Sciences\, National University of Singapore PhD Oral Defence \nSignaling and Mechanical Regulation of Podosome-Type Cell-Matrix Adhesions\nSpeaker: Nisha Mohd Rafiq\n(Graduate Student\, Dept. of Biological Sciences\, NUS\, and Randall Division of King’s College London) \nDate: 19 January 2017\, Thursday\nTime: 4pm\nVenue:  T-Lab Level 5 Seminar Rooms\nSupervisor(s): Prof. Alexander Bershadsky\, Prof. Paul Matsudaira and Prof. Gareth Jones \nAbstract\nPodosomes represent a class of integrin-mediated cell-matrix adhesions formed by migrating and matrix-degrading cells. The talk will comprise of three studies involving the crosstalk of small G-proteins\, the role of actomyosin contractility and membrane tension in regulating podosome dynamics.  Firstly\, I will demonstrate that in macrophage-like THP1 cells and fibroblasts stimulated to produce podosomes\, down-regulation of the G-protein ARF1 and its exchange factor ARNO\, by small interfering RNA or pharmacological inhibitors led to striking podosome elimination. Using super-resolution microscopy\, inhibition of ARF1 led to an increase in active RhoA levels and triggered assembly of myosin-IIA filaments in THP1 cells\, whereas the suppression of myosin-IIA rescued podosome formation regardless of ARF1 inhibition. The expression of constitutively active ARF1 in fibroblasts induced formation of putative podosome precursors that are capable of degrading the matrix. Thus\, ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly. Secondly\, I will demonstrate an adhesion switch mechanism between podosomes and focal adhesions through a microtubule-regulated myosin-II filament turnover. Disruption of microtubules triggered assembly of focal adhesions but disassembly of podosomes\, while recovery of microtubule array suppressed focal adhesions but promoted podosome assembly. Here\, I will show that the effect of microtubules on both focal adhesions and podosomes is mediated by GEF-H1\, a microtubule associated Rho-GEF\, activating the RhoA – ROCK – myosin-II pathway. Finally\, I will discuss preliminary findings on the role of membrane tension in podosome dynamics. Artificial increase in membrane tension by osmotic shock and mechanical stretching curbed podosome formation\, while decreasing its tension promoted podosome clustering\, suggesting that membrane plasticity and/or invagination-related processes can control the assembly of podosomes. \nAll are welcome.
URL:https://www.mbi.nus.edu.sg/event/phd-oral-defense-signaling-and-mechanical-regulation-of-podosome-type-cell-matrix-adhesions-by-nisha-mohd-rafiq/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170120T093000
DTEND;TZID=Asia/Shanghai:20170120T103000
DTSTAMP:20260629T001918
CREATED:20170117T014646Z
LAST-MODIFIED:20170117T014745Z
UID:16491-1484904600-1484908200@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar: Mechanics of Collective Cell Alignment and Polarization in 2D and 3D Environments by Prof Baohua Ji
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-mechanics-of-collective-cell-alignment-and-polarization-in-2d-and-3d-environments-by-prof-baohua-ji/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170124T093000
DTEND;TZID=Asia/Shanghai:20170124T100000
DTSTAMP:20260629T001918
CREATED:20170119T015540Z
LAST-MODIFIED:20170119T015540Z
UID:16500-1485250200-1485252000@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Application of AFM imaging and single-DNA manipulation methods to studying DNA organization by archaeal DNA-architectural proteins by Artem Yefremov
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 24 January at Level 5 Seminar Room. \nPresenter 1: Artem Yefremov \nTalk Title: Application of AFM imaging and single-DNA manipulation methods to studying DNA organization by archaeal DNA-architectural proteins \nThank you. \n 
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-application-of-afm-imaging-and-single-dna-manipulation-methods-to-studying-dna-organization-by-archaeal-dna-architectural-proteins-by-artem-yefremov/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170125T160000
DTEND;TZID=Asia/Shanghai:20170125T170000
DTSTAMP:20260629T001918
CREATED:20170124T034009Z
LAST-MODIFIED:20170124T034009Z
UID:16704-1485360000-1485363600@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar: Proteomic Definition of the Integrin-actin Nexus and the Mechanism for Adhesion Remodeling in G2-phase of the Cell Cycle by Prof Martin J Humphries
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-proteomic-definition-of-the-integrin-actin-nexus-and-the-mechanism-for-adhesion-remodeling-in-g2-phase-of-the-cell-cycle-by-prof-martin-j-humphries/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Shanghai:20170131T093000
DTEND;TZID=Asia/Shanghai:20170131T100000
DTSTAMP:20260629T001918
CREATED:20170125T015321Z
LAST-MODIFIED:20170125T015321Z
UID:16757-1485855000-1485856800@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Nanoscale architecture of cadherin-mediated adhesion by Cristina Bertocchi
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 31 January at Level 5 Seminar Room.  \nNanoscale architecture of cadherin-mediated adhesion\n\nPresenter: Cristina Bertocchi
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-nanoscale-architecture-of-cadherin-mediated-adhesion-by-cristina-bertocchi/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
END:VCALENDAR