BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://www.mbi.nus.edu.sg X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:UTC BEGIN:STANDARD TZOFFSETFROM:+0000 TZOFFSETTO:+0000 TZNAME:UTC DTSTART:20150101T000000 END:STANDARD END:VTIMEZONE BEGIN:VTIMEZONE TZID:Asia/Shanghai BEGIN:STANDARD TZOFFSETFROM:+0800 TZOFFSETTO:+0800 TZNAME:CST DTSTART:20150101T000000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=UTC:20161202T093000 DTEND;TZID=UTC:20161202T103000 DTSTAMP:20260629T050754 CREATED:20161128T221101Z LAST-MODIFIED:20161128T221101Z UID:16236-1480671000-1480674600@www.mbi.nus.edu.sg SUMMARY:MBI Weekly Seminar: How does microenvironment influence Apico basal polarity by Virgile Viasnoff DESCRIPTION:Please be informed of MBI Weekly Meeting Seminar this Friday\, 2 December as follows: \nTime: 9:30am\nVenue: T-Lab Level 5 Seminar Room\nPresenter: Virgile Viasnoff\nTalk Title: “How does microenvironment influence Apico basal polarity” \nAbstract: The importance of the biophysical cues of cellular microniches in the context of tissue homeostasis and diseases are being progressively uncovered. We present here a set of new methodological approaches that allows to precisely control in vitro the environmental parameters surrounding 1 to 100 cells in a combinatorial way. Our approach also permits 3D super resolution imaging of cells across the entire cell body. We illustrate how this techniques can be used to induce  apico-basal polarity of a single cell in the context of epithelial cells and hepatocytes. Lastly\, we explore how local application of mechanical stresses contributes to the localization and  maturation of the tight junction belt. URL:https://www.mbi.nus.edu.sg/event/mbi-weekly-seminar-how-does-microenvironment-influence-apico-basal-polarity-by-virgile-viasnoff/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Weekly Seminar END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20161204 DTEND;VALUE=DATE:20170109 DTSTAMP:20260629T050754 CREATED:20161221T014750Z LAST-MODIFIED:20161221T014750Z UID:16444-1480809600-1483919999@www.mbi.nus.edu.sg SUMMARY:NUS Academic Calendar: Semester break DESCRIPTION: URL:https://www.mbi.nus.edu.sg/event/nus-academic-calendar-semester-break/ LOCATION:National University of Singapore CATEGORIES:NUS Academic Calendar END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20161205T100000 DTEND;TZID=UTC:20161205T110000 DTSTAMP:20260629T050754 CREATED:20161130T203204Z LAST-MODIFIED:20161130T203241Z UID:16330-1480932000-1480935600@www.mbi.nus.edu.sg SUMMARY:MBI PhD Oral Defence: Frequency and Amplitude Control of Cortical Oscillations by Lipid Metabolism by Xiong Ding DESCRIPTION:Speaker: XIONG Ding (Graduate Student\, MBI\, NUS)\nDate: 5 December 2016\, Monday\nTime: 10am\nVenue: MBI\, T-lab\, level 5 seminar rooms \nSupervisor(s): Prof Wu Min \nAbstract: Dynamic patterns\, such as oscillations and waves\, of signaling factors are of great importance to cell physiology in many single and multicellular systems. Currently\, majority of the studies focus primarily on cytoskeleton-dependent feedbacks. In contrast\, information on signaling mechanisms upstream of the actin cytoskeleton remains unclear. \nIn this study\, I report phosphoinositides traveling waves on plasma membrane of rat basophilic leukemia (RBL) mast cells (Xiong et al. 2016). Sequential waves of phosphoinositides are generated by two phase-shifted phosphoinositide phosphatases namely synaptojanin 2 and SHIP1. By perturbing phosphoinositides using optogenetic methods and chemical drugs\, I demonstrate that the pulses of PtdIns(4\,5)P2 regulate the amplitude of cyclic membrane waves while PtdIns(3\,4)P2 sets the frequency. Class I PI3Kδ is the main functional PI3K involved in regulating the frequency through phosphatase-dependent inhibitory action. Besides\, dynamic patterns of global oscillations have been observed on plasma membrane and ER membrane coupling with calcium oscillations. Cyclic recruitment of calcium channel STIM1 on ER membrane is synchronized with the PtdIns(4)P dynamics. Collectively\, the spatiotemporal dynamics of lipid metabolism have a key role in efficiently directing signals on plasma membrane and ER membrane. \nALL EXCEPT PANEL ARE EXCUSED FOR CLOSE DOOR EXAMINATION URL:https://www.mbi.nus.edu.sg/event/phd-oral-defence-frequency-and-amplitude-control-of-cortical-oscillations-by-lipid-metabolism-by-xiong-ding/ LOCATION:National University of Singapore CATEGORIES:PhD Oral Defense END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20161205T160000 DTEND;TZID=UTC:20161205T170000 DTSTAMP:20260629T050754 CREATED:20161127T194740Z LAST-MODIFIED:20161127T194740Z UID:16232-1480953600-1480957200@www.mbi.nus.edu.sg SUMMARY:MBI Seminar: Use of a light-inducible oncogene to study cell competition by Isabelle Bonnet DESCRIPTION:I am pleased to inform you on the seminar by Isabelle Bonnet “Use of a light-inducible oncogene to study cell competition” on 05 December (Monday) @ 4pm at T-Lab Level 5 Seminar Rooms. Thank you. URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-use-of-a-light-inducible-oncogene-to-study-cell-competition-by-isabelle-bonnet/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Asia/Shanghai:20161206T093000 DTEND;TZID=Asia/Shanghai:20161206T100000 DTSTAMP:20260629T050754 CREATED:20161205T053532Z LAST-MODIFIED:20161205T053532Z UID:16403-1481016600-1481018400@www.mbi.nus.edu.sg SUMMARY:MBI SPSS: Large-scale curvature sensing by directional actin flow drives cellular migration mode switching by Chen Tianchi DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am tomorrow\, 6 December at Level 5 Seminar Room. \nPresenter 1: Chen Tianchi \nTalk Title: Large-scale curvature sensing by directional actin flow drives cellular migration mode switching \nPresenter 2: Sabyasachi Dasgupta \nTalk Title: Fluidization of  tissues: Due to cell-scale activity \n  URL:https://www.mbi.nus.edu.sg/event/mbi-spss-large-scale-curvature-sensing-by-directional-actin-flow-drives-cellular-migration-mode-switching-by-chen-tianchi/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Student & Postdoc Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Asia/Shanghai:20161206T100000 DTEND;TZID=Asia/Shanghai:20161206T103000 DTSTAMP:20260629T050754 CREATED:20161205T053636Z LAST-MODIFIED:20161205T053713Z UID:16405-1481018400-1481020200@www.mbi.nus.edu.sg SUMMARY:MBI SPSS: Fluidization of tissues: Due to cell-scale activity by Sabyasachi Dasgupta DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am tomorrow\, 6 December at Level 5 Seminar Room. \nPresenter 1: Chen Tianchi \nTalk Title: Large-scale curvature sensing by directional actin flow drives cellular migration mode switching \nPresenter 2: Sabyasachi Dasgupta \nTalk Title: Fluidization of  tissues: Due to cell-scale activity URL:https://www.mbi.nus.edu.sg/event/mbi-spss-fluidization-of-tissues-due-to-cell-scale-activity-by-sabyasachi-dasgupta/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Student & Postdoc Seminar END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20161207 DTEND;VALUE=DATE:20161211 DTSTAMP:20260629T050754 CREATED:20161114T192142Z LAST-MODIFIED:20161114T192222Z UID:15935-1481068800-1481414399@www.mbi.nus.edu.sg SUMMARY:16th International Conference on Biomedical Engineering (ICBME 2016) DESCRIPTION:I am pleased to inform you that the NUS Department of Biomedical Engineering together with Biomedical Engineering Society (Singapore) are joint organisers of the 16th International Conference on Biomedical Engineering (ICBME 2016). The conference will be held in the Stephen Riady Centre\, University Town\, National University of Singapore. We have invited quite a number of internationally well-known speakers. For more information\, please download the full conference program using the link in the eDM below. \nI would like to encourage you and your research staff and students  to join us in this triennial conference. \nFull information at www.icbme.org URL:https://www.mbi.nus.edu.sg/event/16th-international-conference-on-biomedical-engineering-icbme-2016/ LOCATION:National University of Singapore CATEGORIES:Conference END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20161207T163000 DTEND;TZID=UTC:20161207T170000 DTSTAMP:20260629T050754 CREATED:20161121T175215Z LAST-MODIFIED:20161121T175215Z UID:16149-1481128200-1481130000@www.mbi.nus.edu.sg SUMMARY:Shape Transitions in Some Systems Involving Surface and Line Energy by Prof Elliot Fried DESCRIPTION:We are pleased to announce a seminar talk by Prof. Elliot Fried who is visiting us at the MBI. \nThe seminar is on Dec 7th (Wed) at 4.30 pm\, T Lab Level 5 seminar room. If you are interested to speak to him before the seminar please feel free to write to me () or Jeff (mbijr@nus.edu.sg) \nShape transitions in some systems involving surface and line energy\nWe will present a variational problem for finding energetically preferred equilibrium configurations of a system consisting of a closed\, inextensible\, unshearable loop endowed with elastic resistance to bending that is spanned by a liquid film endowed with constant surface tension. Aside from presenting results from bifurcation and stability analyses based on the first and second variations of the relevant energy functional\, we will discuss generalizations of the problem. In particular\, we will describe the consequences of incorporating elastic resistance to twisting the bounding loop and bending the spanning film. We will also mention applications to experiments involving discoidal high-density lipoprotein particles and synthetic nanodiscs. URL:https://www.mbi.nus.edu.sg/event/shape-transitions-in-some-systems-involving-surface-and-line-energy-by-prof-elliot-fried/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Theory Group END:VEVENT BEGIN:VEVENT DTSTART;TZID=Asia/Shanghai:20161208T110000 DTEND;TZID=Asia/Shanghai:20161208T120000 DTSTAMP:20260629T050754 CREATED:20161205T014037Z LAST-MODIFIED:20161205T014037Z UID:16401-1481194800-1481198400@www.mbi.nus.edu.sg SUMMARY:MBI PhD Oral Defense: Study the Role of Micro-Niches in Epithelial Apical-Basal Polarisation by Weng Zhe DESCRIPTION:Speaker: WENG Zhe (Graduate Student\, MBI\, NUS)\nDate: 8 December 2016\, Thursday\nTime: 11am\nVenue: MBI\, T-lab\, level 5 seminar rooms \nSupervisor(s): Prof Viasnoff Virgile \nAbstract: Epithelia apical-basal polarisation is important for the formation of a selective barrier. The establishment of distinct “apical”\, “lateral”\, and “basal” functional domains is mainly studied at tissue or multiple cell level. It is difficult to decouple the chemical and physical parameters precisely in the conventional system. This thesis developed a novel micro-well based mini-organ approach to precisely control the 3-D micro-niches\, and quantitatively assessed the localization of key polarity markers. \nThis thesis work has reported that at single cell level\, epithelial apical-basal polarisation phenotype similar to “zonula adherens” could be induced by the 3-D biomimetic micro-niches. It reveals that lateral input of cell-cell adhesion cue is crucial for the formation of apically localized “zonula adherens” belt structure identified by an actin belt\, together with PAR-3\, N-WASP\, ZO-1 and Claudin-3. The cell-matrix adhesion cue alone in 3-D micro-niches could not support the apically localized belt formation. 2-D input of cell-cell adhesion cues also induced an edge localized E-cadherin and actin belt. Taken together\, this thesis demonstrates that cell-cell adhesion cues in 3-D and 2-D micro-niches are sufficient to develop “zonula adherens” like belt formation at single cell level\, and creates a novel tool to quantitatively imaging and analysis of key polarity marker in 3-D micro-niches. \nALL EXCEPT PANEL ARE EXCUSED FOR CLOSE DOOR EXAMINATION URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-study-the-role-of-micro-niches-in-epithelial-apical-basal-polarisation-by-weng-zhe/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:PhD Oral Defense END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20161212T103000 DTEND;TZID=UTC:20161212T113000 DTSTAMP:20260629T050754 CREATED:20161127T194551Z LAST-MODIFIED:20161127T194551Z UID:16229-1481538600-1481542200@www.mbi.nus.edu.sg SUMMARY:MBI Seminar: Mechanosensing at tight junctions controls the transcription factor DbpA through autoinhibitory folding of ZO proteins by Sandra Citi DESCRIPTION:We are pleased to inform you on the seminar by Sandra Citi “Mechanosensing at tight junctions controls the transcription factor DbpA through autoinhibitory folding of ZO proteins” on 12 December (Monday) @ 10.30am at T-Lab Level 5 Seminar Rooms. Thank you. URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-mechanosensing-at-tight-junctions-controls-the-transcription-factor-dbpa-through-autoinhibitory-folding-of-zo-proteins-by-sandra-citi/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Asia/Shanghai:20161213T093000 DTEND;TZID=Asia/Shanghai:20161213T100000 DTSTAMP:20260629T050754 CREATED:20161209T020721Z LAST-MODIFIED:20161209T020944Z UID:16422-1481621400-1481623200@www.mbi.nus.edu.sg SUMMARY:MBI SPSS: Geometric confinement of cells induces nuclear reprogramming by Bibhas Roy DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 13 December at Level 5 Seminar Room. \nPresenter 1: Bibhas Roy\nTalk Title: Geometric confinement of cells induces nuclear reprogramming \nPresenter 2: Yukako Nishimura\nTalk Title: Mechanisms of focal adhesion turnover during cell migration URL:https://www.mbi.nus.edu.sg/event/13-dec-geometric-confinement-of-cells-induces-nuclear-reprogramming-by-bibhas-roy/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Student & Postdoc Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Asia/Shanghai:20161213T100000 DTEND;TZID=Asia/Shanghai:20161213T103000 DTSTAMP:20260629T050754 CREATED:20161209T020817Z LAST-MODIFIED:20161209T020924Z UID:16424-1481623200-1481625000@www.mbi.nus.edu.sg SUMMARY:MBI SPSS: Mechanisms of focal adhesion turnover during cell migration by Yukako Nishimura DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 13 December at Level 5 Seminar Room. \nPresenter 1: Bibhas Roy\nTalk Title: Geometric confinement of cells induces nuclear reprogramming \nPresenter 2: Yukako Nishimura\nTalk Title: Mechanisms of focal adhesion turnover during cell migration URL:https://www.mbi.nus.edu.sg/event/13-dec-mechanisms-of-focal-adhesion-turnover-during-cell-migration-by-yukako-nishimura/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Student & Postdoc Seminar END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20161214 DTEND;VALUE=DATE:20161216 DTSTAMP:20260629T050754 CREATED:20161115T211312Z LAST-MODIFIED:20161115T211325Z UID:16085-1481673600-1481846399@www.mbi.nus.edu.sg SUMMARY:Imaris Training Workshop DESCRIPTION:Dear all\, \nImaris training workshop will be held at MBI\, level 5 seminar room on 14th-15th December 2016. You will learn how to analyze your data using Imaris 8.4 through lectures and hands-on sessions. For registration\, please email hui ting (mbioht@nus.edu.sg) with the following details by 24th November.  * No fee is required. \nName : \nPI : \nEmail : \nMobile number : \nAfter the closing date\, successful registrants will be notified. Successful registrants have to bring their own laptop for the 2 day workshop. \nFor detailed schedule\, please refer to http://microscopy.mechanobio.info/ \nThanks. \nhui ting URL:https://www.mbi.nus.edu.sg/event/imaris-training-workshop/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:Workshop END:VEVENT BEGIN:VEVENT DTSTART;TZID=Asia/Shanghai:20161216T110000 DTEND;TZID=Asia/Shanghai:20161216T120000 DTSTAMP:20260629T050754 CREATED:20161214T014531Z LAST-MODIFIED:20161214T014531Z UID:16433-1481886000-1481889600@www.mbi.nus.edu.sg SUMMARY:IMCB Seminar: How do regulatory T cells adapt to the adipose tissue environment? by Ajith Vasanthakum DESCRIPTION: URL:https://www.mbi.nus.edu.sg/event/imcb-seminar-how-do-regulatory-t-cells-adapt-to-the-adipose-tissue-environment-by-ajith-vasanthakum/ LOCATION:National University of Singapore CATEGORIES:A*STAR Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Asia/Shanghai:20161220T093000 DTEND;TZID=Asia/Shanghai:20161220T100000 DTSTAMP:20260629T050754 CREATED:20161214T013555Z LAST-MODIFIED:20161214T013625Z UID:16430-1482226200-1482228000@www.mbi.nus.edu.sg SUMMARY:MBI SPSS: Quantitative Topological Analysis of Microtubule Networks from Single-Molecule Localization Microscopy Images by Zhang Zhen DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am on 20 December at Level 5 Seminar Room. \nPresenter: Zhang Zhen \nTalk Title: Quantitative Topological Analysis of Microtubule Networks from Single-Molecule Localization Microscopy Images URL:https://www.mbi.nus.edu.sg/event/quantitative-topological-analysis-of-microtubule-networks-from-single-molecule-localization-microscopy-images-by-zhang-zhen/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:MBI Student & Postdoc Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Asia/Shanghai:20161220T150000 DTEND;TZID=Asia/Shanghai:20161220T160000 DTSTAMP:20260629T050754 CREATED:20161216T015435Z LAST-MODIFIED:20161216T015435Z UID:16436-1482246000-1482249600@www.mbi.nus.edu.sg SUMMARY:MBI PhD Oral Defense: Intracellular Pattern Formation of F-Bar Protein FBP17 by SU Mao Han DESCRIPTION:Speaker: SU Mao Han (Graduate Student\, MBI\, NUS) \nDate: 20 December 2016\, Tuesday \nTime: 3pm \nVenue: MBI\, T-lab\, level 5 seminar rooms \nSupervisor(s): Prof WU Min \nAbstract: Living  cells  exhibit  various  dynamic  biological  patterns  in  the  forms  of  waves and  oscillations.  Increasing  attention  is  paid  to  their  functions  in  efficient  and robust  signal  transduction. However\,  whether  plasma  membrane  plays  an  active role in wave propagation remains to be answered. \nIn  this  work\,  I  characterized  the  mechanism  of  intracellular  pattern  formation of  FBP17\,  a  curvature-generating  protein  that  functions  upstream  of  actin polymerization.  Travelling  waves  of  FBP17  mechanically  depend  on  plasma membrane and the  appropriate  curvature  of  F-BAR  is  crucial  for  membrane undulation  and  wave  propagation.  My  results  present  a  biological  system  where membrane-shape-mediated  mechano-chemical  feedback  is  critical  for spatiotemporal  pattern  formation.  This  curvature-mediated  coupling  is  a  novel mechanism for rapid transduction of signals across cell membrane. \nALL EXCEPT PANEL ARE EXCUSED FOR CLOSE DOOR EXAMINATION URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-intracellular-pattern-formation-of-f-bar-protein-fbp17-by-su-mao-han/ LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore CATEGORIES:PhD Oral Defense END:VEVENT END:VCALENDAR