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PRODID:-//Mechanobiology Institute, National University of Singapore - ECPv6.15.12.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20150101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=UTC:20161101T090000
DTEND;TZID=UTC:20161101T100000
DTSTAMP:20260626T071656
CREATED:20161030T181838Z
LAST-MODIFIED:20161030T181838Z
UID:15588-1477990800-1477994400@www.mbi.nus.edu.sg
SUMMARY:No MBI SPSS seminar this week
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/no-mbi-spss-seminar-this-week/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161101T160000
DTEND;TZID=UTC:20161101T170000
DTSTAMP:20260626T071656
CREATED:20161031T181218Z
LAST-MODIFIED:20161031T181218Z
UID:15637-1478016000-1478019600@www.mbi.nus.edu.sg
SUMMARY:CBIS Seminar: In Situ Investigations of Particle-Mediated Crystal Growth by Dongsheng Li
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/cbis-seminar-in-situ-investigations-of-particle-mediated-crystal-growth-by-dongsheng-li/
LOCATION:CBIS Seminar Room\, S1A-02-17\, Singapore\, 117557\, Singapore
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161103T150000
DTEND;TZID=UTC:20161103T160000
DTSTAMP:20260626T071656
CREATED:20161031T180510Z
LAST-MODIFIED:20161031T180510Z
UID:15634-1478185200-1478188800@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar: The Functional Topology and Dynamics of the Pharmacoepigenome by Brian Athey
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-the-functional-topology-and-dynamics-of-the-pharmacoepigenome-by-brian-athey/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20161104
DTEND;VALUE=DATE:20161105
DTSTAMP:20260626T071656
CREATED:20161102T181129Z
LAST-MODIFIED:20161102T184643Z
UID:15743-1478217600-1478303999@www.mbi.nus.edu.sg
SUMMARY:No MBI Weekly Meeting Friday
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/mbi-weekly-meeting-no-meeting-this-week/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:signboard only
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20161107
DTEND;VALUE=DATE:20161110
DTSTAMP:20260626T071656
CREATED:20160913T194635Z
LAST-MODIFIED:20161031T180613Z
UID:14232-1478476800-1478735999@www.mbi.nus.edu.sg
SUMMARY:CSI Conference: 2016 Frontiers in Cancer Science
DESCRIPTION:Notice on the upcoming conference\, Frontiers in Cancer Science 2016. The Frontiers in Cancer Science (FCS) 2016\, our 8th annual conference\, is jointly organized by the Cancer Science Institute of Singapore (CSI Singapore)\, Duke-NUS Medical School\, Institute of Molecular and Cell Biology (IMCB)\, Lee Kong Chian School of Medicine (LKCMedicine)\, National Cancer Centre Singapore (NCCS) and National University Cancer Institute\, Singapore (NCIS). \nConverging the latest cancer discoveries around the world\, the meeting promises ground-breaking and innovative insights into cancer research. Join us and learn from the foremost cancer experts as they share their newest findings. \nMore information
URL:https://www.mbi.nus.edu.sg/event/csi-conference-2016-frontiers-in-cancer-science/
LOCATION:University Cultural Centre (UCC)\, 50 Kent Ridge Cres\, National University of Singapore\, Singapore\, 119279\, Singapore
CATEGORIES:CSI
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161108T090000
DTEND;TZID=UTC:20161108T093000
DTSTAMP:20260626T071656
CREATED:20161106T181920Z
LAST-MODIFIED:20161106T182106Z
UID:15842-1478595600-1478597400@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Effects of force on mDia1-dependent Actin Polymerization by Yu Miao
DESCRIPTION:Please be informed of SPSS Meeting Seminar tomorrow\, 8 November as follows \nPresenter   1: Yu Miao\nTalk Title: “Effects of force on mDia1-dependent Actin Polymerization”\nVenue : Level 5 Seminar Room
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-effects-of-force-on-mdia1-dependent-actin-polymerization-by-yu-miao/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161108T093000
DTEND;TZID=UTC:20161108T100000
DTSTAMP:20260626T071656
CREATED:20161106T182040Z
LAST-MODIFIED:20161106T182040Z
UID:15845-1478597400-1478599200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Regulation of formin FHOD1 and Arp2/3 by bacterial pathogen EPEC by Mrinal Dinesh Shah
DESCRIPTION:Please be informed of SPSS Meeting Seminar tomorrow\, 8 November as follows \nPresenter   2: Mrinal Dinesh Shah\nTalk Title: “Regulation of formin FHOD1 and Arp2/3 by bacterial pathogen EPEC”\nVenue: Level 5 Seminar Room
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-regulation-of-formin-fhod1-and-arp23-by-bacterial-pathogen-epec-by-mrinal-dinesh-shah/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161109T160000
DTEND;TZID=UTC:20161109T170000
DTSTAMP:20260626T071656
CREATED:20161030T182147Z
LAST-MODIFIED:20161030T183223Z
UID:15590-1478707200-1478710800@www.mbi.nus.edu.sg
SUMMARY:BIGHEART Seminar: Microfluidics for Precision Medicine
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/bigheart-seminar-microfluidics-for-precision-medicine/
LOCATION:BIGHEART Seminar\, CeLS Seminar Room 1\, Singapore\, 117456\, Singapore
CATEGORIES:Biomedical Institute for Global Health Research & Technology (BIGHEART)
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161110T150000
DTEND;TZID=UTC:20161110T160000
DTSTAMP:20260626T071656
CREATED:20161102T184558Z
LAST-MODIFIED:20161102T184558Z
UID:15750-1478790000-1478793600@www.mbi.nus.edu.sg
SUMMARY:MBI Career Committee: Meet the Scientists Panel
DESCRIPTION:MBI Students and Post-Docs\, \nThe MBI career committee is holding the first of its “Meet the Scientists” panel on Thursday\, 10th November\, 3pm-4pm at L5 Meeting Room. The goal of the panel is to provide students and post-docs a better understanding of the academic career path through real life examples. This will be an opportunity to ask the scientists career questions you have been seeking answers for\, including\, what are the challenges they faced?\, how those were overcome?\, their present challenges etc!\nDo seize the opportunity and participate/attend the panel discussion. \nThe scientists participating in this first session: \n1) Prof. Michael Sheetz \n2) Prof. Cynthia He \n3) Prof. Yusuke Toyama \n— Career Committee\, MBI
URL:https://www.mbi.nus.edu.sg/event/mbi-career-committee-meet-the-scientists-panel/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Career Committee,MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161111T093000
DTEND;TZID=UTC:20161111T103000
DTSTAMP:20260626T071656
CREATED:20161107T205842Z
LAST-MODIFIED:20161107T205842Z
UID:15916-1478856600-1478860200@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar: Mechano-Genomics: From Big Data to Disease Diagnosis by GV Shivashankar
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-mechano-genomics-from-big-data-to-disease-diagnosis-by-gv-shivashankar/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161111T160000
DTEND;TZID=UTC:20161111T170000
DTSTAMP:20260626T071656
CREATED:20161106T183039Z
LAST-MODIFIED:20161106T183914Z
UID:15848-1478880000-1478883600@www.mbi.nus.edu.sg
SUMMARY:DBS Colloquium: Dissecting the Mechanistic Basis of Cell Size Control in Fission Yeast by Martin Howard
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/dbs-colloquium-dissecting-the-mechanistic-basis-of-cell-size-control-in-fission-yeast/
LOCATION:DBS Conference Room 1\, 14 Science Drive 4\, Singapore\, 117543\, Singapore
CATEGORIES:Biology Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20161112
DTEND;VALUE=DATE:20161113
DTSTAMP:20260626T071656
CREATED:20161115T174353Z
LAST-MODIFIED:20161121T175536Z
UID:16080-1478908800-1478995199@www.mbi.nus.edu.sg
SUMMARY:NUS Academic Calendar: Reading Week/Exams
DESCRIPTION:Reading Week\nSat\, 12 Nov 2016 ~ Fri\, 18 Nov 2016 1 week \nExamination\nSat\, 19 Nov 2016 ~ Sat\, 3 Dec 2016 2 weeks \nVacation\nSun\, 4 Dec 2016 ~ Sun\, 8 Jan 2017 (d) & (e) \nSemester 2 Classes Begin\nMon\, 9 Jan 2017 ~ Sat\, 6 May 2017 \nFull NUS Academic Calendar
URL:https://www.mbi.nus.edu.sg/event/nus-academic-calendar-reading-weekexams/
LOCATION:National University of Singapore
CATEGORIES:NUS Academic Calendar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161115T173000
DTEND;TZID=UTC:20161115T183000
DTSTAMP:20260626T071656
CREATED:20161114T193045Z
LAST-MODIFIED:20161114T193057Z
UID:15937-1479231000-1479234600@www.mbi.nus.edu.sg
SUMMARY:MBI WIS: Five Words that Changed my Life by Prof Linda J Kenney @ IMB\, Biopolis
DESCRIPTION:Tuesday\, 15 November\, 2016\, 5.30pm at IMB (Institute of Medical Biology) Seminar Room NEUROS\, Level 6\, Biopolis (see map) \nMBI’s Linda J Kenney will be speaking at Biopolis on Tuesday the 15th of November on “Five Words That Changed My Life.” Prof Kenney is a principal investigator at MBI whose lab specializes in signal transduction and the regulation of gene expression in prokaryotes. In particular\, they are studying the two-component regulatory system EnvZ/OmpR that regulates the expression of outer membrane proteins as well as many other genes. \nDr Kenney’s present work focuses on how OmpR activates genes required for systemic infection (located on Salmonella pathogenicity island 2) in Salmonella enterica. Learn more about Prof Kenney’s research.
URL:https://www.mbi.nus.edu.sg/event/mbi-wis-five-words-that-changed-my-life-by-prof-linda-j-kenney-imb-biopolis/
LOCATION:National University of Singapore
CATEGORIES:MBI WIS
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161118T090000
DTEND;TZID=UTC:20161118T100000
DTSTAMP:20260626T071656
CREATED:20161117T172547Z
LAST-MODIFIED:20161117T172547Z
UID:16100-1479459600-1479463200@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: No meeting this week
DESCRIPTION:Please be informed that there will be no MBI weekly meeting tomorrow.
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-no-meeting-this-week/
LOCATION:National University of Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161122T090000
DTEND;TZID=UTC:20161122T213000
DTSTAMP:20260626T071656
CREATED:20161121T174509Z
LAST-MODIFIED:20161121T174509Z
UID:16145-1479805200-1479850200@www.mbi.nus.edu.sg
SUMMARY:SPSS Seminar: Spatial temporal regulation of EphA2-integrin signaling crosstalk by Chen Zhongwen
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am tomorrow\, 22 November at Level 5 Seminar Room \nPresenter 1: Chen Zhongwen\nTalk Title: Spatial temporal regulation of EphA2-integrin signaling crosstalk \nPresenter 2: Yusuke Hara\nTalk Title: Fluctuations of junctional tension and adherens junction molecules during epithelial cell oscillation
URL:https://www.mbi.nus.edu.sg/event/spss-seminar-spatial-temporal-regulation-of-epha2-integrin-signaling-crosstalk-by-chen-zhongwen/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161122T093000
DTEND;TZID=UTC:20161122T100000
DTSTAMP:20260626T071656
CREATED:20161121T174604Z
LAST-MODIFIED:20161121T174604Z
UID:16147-1479807000-1479808800@www.mbi.nus.edu.sg
SUMMARY:SPSS Seminar: Fluctuations of junctional tension and adherens junction molecules during epithelial cell oscillation by Yusuke Hara
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am tomorrow\, 22 November at Level 5 Seminar Room \nPresenter 1: Chen Zhongwen\nTalk Title: Spatial temporal regulation of EphA2-integrin signaling crosstalk \nPresenter 2: Yusuke Hara\nTalk Title: Fluctuations of junctional tension and adherens junction molecules during epithelial cell oscillation
URL:https://www.mbi.nus.edu.sg/event/spss-seminar-fluctuations-of-junctional-tension-and-adherens-junction-molecules-during-epithelial-cell-oscillation-by-yusuke-hara/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161122T120000
DTEND;TZID=UTC:20161122T130000
DTSTAMP:20260626T071656
CREATED:20161117T233634Z
LAST-MODIFIED:20161117T233711Z
UID:16104-1479816000-1479819600@www.mbi.nus.edu.sg
SUMMARY:DukeNUS Medical School: Understanding the Role of Interleukin-11 in Inflammatory Diseases and Cancer by Dr Tracy Putoczki
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/dukenus-medical-school-understanding-the-role-of-interleukin-11-in-inflammatory-diseases-and-cancer-by-dr-tracy-putoczki/
LOCATION:DukeNUS Medical School\, 8 College Road\, Amphitheatre\, Level 2\, Singapore\, 169857\, Singapore
CATEGORIES:DukeNUS Medical School
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161122T143000
DTEND;TZID=UTC:20161122T173000
DTSTAMP:20260626T071656
CREATED:20161121T190347Z
LAST-MODIFIED:20161121T190551Z
UID:16153-1479825000-1479835800@www.mbi.nus.edu.sg
SUMMARY:Welcome to Students and Staff of the Nobel Science Camp\, NUS High School
DESCRIPTION:Today\, Tuesday\, November 22 from 2:30 to 5:30pm\, MBI will be hosting (for the third time) students from the Nobel Science Camp organized  by the NUS high school. This time we are expecting 100 students and 6 teachers. \nPlease note that due to the large size of the group we are running three lab tours on L9 consecutively between 2:30pm and 5:30pm. Although we have minimized the number of visitors inside the lab at a time\, there may still be some crowding near benches where lab demos are to be held. \nAlso L10 lobby will be used to conduct a mechanobiology theme based game. We would appreciate your cooperation in the smooth progress of the lab demos and in keeping the L10 lobby area free from 2:30pm to 5:30pm. \nPlease plan your experiments with this in mind and thank you for your understanding. \nIf you have any questions regarding this outreach event\, please contact the SciComms team on L5.
URL:https://www.mbi.nus.edu.sg/event/welcome-to-students-and-staff-of-the-nobel-science-camp-nus-high-school/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:Outreach Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161123T150000
DTEND;TZID=UTC:20161123T160000
DTSTAMP:20260626T071656
CREATED:20161121T174151Z
LAST-MODIFIED:20161121T174151Z
UID:16142-1479913200-1479916800@www.mbi.nus.edu.sg
SUMMARY:CBIS Seminar: Macromolecular Coherent Diffractive Imaging using Disordered Crystals by Dr Kartik Ayyer
DESCRIPTION:
URL:https://www.mbi.nus.edu.sg/event/cbis-seminar-macromolecular-coherent-diffractive-imaging-using-disordered-crystals-by-dr-kartik-ayyer/
LOCATION:CBIS Seminar Room\, S1A-02-17\, Singapore\, 117557\, Singapore
CATEGORIES:CBIS
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161124T140000
DTEND;TZID=UTC:20161124T150000
DTSTAMP:20260626T071656
CREATED:20161114T191932Z
LAST-MODIFIED:20161114T192616Z
UID:15933-1479996000-1479999600@www.mbi.nus.edu.sg
SUMMARY:A*STAR Seminar: NMR Hyperpolarized Contrast Agents for Molecular Imaging by Dr Eduard Chekmenev
DESCRIPTION:Please find attached a seminar to be presented by Dr Eduard Chekmenev. \nTitle of Seminar :  NMR Hyperpolarized Contrast Agents for Molecular Imaging \nHost :  Dr Edward Robins\nDate :  25 November\, Friday\nTime : 11.00am – 12.00noon \nVenue : SBIC Seminar Room\, 11 Biopolis Way\, Helios Building\, Level 2 (Please enter via Level 1) \nFull announcement here.
URL:https://www.mbi.nus.edu.sg/event/astar-seminar-nmr-hyperpolarized-contrast-agents-for-molecular-imaging-by-dr-eduard-chekmenev/
LOCATION:A*STAR IMCB Seminar Room\, Level 3\, IMCB Seminar Room 3-46\, Proteos\, Biopolis\, 138673\, Singapore
CATEGORIES:A*STAR Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161125T093000
DTEND;TZID=UTC:20161125T103000
DTSTAMP:20260626T071656
CREATED:20161122T184948Z
LAST-MODIFIED:20161122T184948Z
UID:16202-1480066200-1480069800@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar: Large Area Fast Pillar Tracking by Felix Margadant
DESCRIPTION:Please be informed of MBI Weekly Meeting Seminar this Friday\,25 November as follows: \nTime: 9:30am\nVenue: T-Lab Level 5 Seminar Room\nPresenter: Felix Margadant\nTalk Title: Large Area Fast Pillar Tracking \nAbstract\nPillar substrates that isolate forces to a locally limited deflection of one or few pillars have been a method of choice for generating medium-density resolution force maps for over a decade. Unlike localization microscopy and gel substrates it provides regular sampling intervals that allow for establishing Nyquist limits of the observations and a complete and consistent overview of the total forces involved. \nFrom Benoit’s early observation that the pillars can be manufactured at an accuracy far better than the optical resolution limit\, we derived the methods for absolute force measurements without the need of a reference and without external calibration.  More recently however\, the better-than-optical quality started to haunt our system: for large fields of observation\, the optical aberrations – no matter how small – begin to dominate the accuracy limit and lower it to unacceptable levels.  This talk is an overview of the ad-hoc and systematic solutions to control and counter this problem and an outlook at the chances of preserving a calibration-free system.”
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-large-area-fast-pillar-tracking-by-felix-margadant/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161128T160000
DTEND;TZID=UTC:20161128T170000
DTSTAMP:20260626T071656
CREATED:20161121T190042Z
LAST-MODIFIED:20161121T190042Z
UID:16151-1480348800-1480352400@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense: Deconstructing Cell Motility in Fibrous Environment by Charolette Guetta
DESCRIPTION:Deconstructing cell motility in fibrous environment\nSpeaker: Charlotte GUETTA (Graduate Student\, MBI\, NUS)\nDate: 28 November 2016\, Monday\nTime: 4pm\nVenue: MBI\, T-lab\, level 5 seminar rooms \nSupervisor(s): Prof Michael Sheetz and Prof Benoit Ladoux \nAbstract\nIn vivo\, cells migrate on complex 3D fibrous matrices\, which has made investigation of the key molecular and physical mechanisms that drive cell migration difficult. Using reductionist approaches to recreate in vitro a simplified fibrous environment\, we investigate the molecular and mechanical properties of cell migrating along suspended fibronectin-coated nanofibers\, First\, we report that single cell migration under such conditions requires the formation and propagation of dynamic actin based fin-like protrusions. These protrusions propagate up to hundred micrometers from the cell body\, extending the leading edge and promoting highly persistent directional movement. The waves originate from one major adhesion site at leading end of the cell body\, which is linked through actomyosin contractility to another site at the back of the cell\, allowing force generation\, matrix deformation and cell translocation. Then\, we develop a novel system associating nanofibers and micropillars in order to probe the forces generated by cells. \n  \nALL EXCEPT PANEL ARE EXCUSED FOR CLOSE DOOR EXAMINATION
URL:https://www.mbi.nus.edu.sg/event/mbi-phd-oral-defense-deconstructing-cell-motility-in-fibrous-environment-by-charolette-guetta/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161129T090000
DTEND;TZID=UTC:20161129T093000
DTSTAMP:20260626T071656
CREATED:20161127T194248Z
LAST-MODIFIED:20161127T194306Z
UID:16227-1480410000-1480411800@www.mbi.nus.edu.sg
SUMMARY:MBI SPSS: Topography sensing by endothelial cells: Role of PTP1B by Azita Gorji
DESCRIPTION:Please be informed of SPSS Meeting Seminar @ 9.30am tomorrow\, 29 November at Level 5 Seminar Room.  \nPresenter 1         :           Azita Gorji\nTalk Title             :           Topography sensing by endothelial cells: Role of PTP1B \nPresenter 2        :           Huang Anqi\nTalk Title            :           To be advised
URL:https://www.mbi.nus.edu.sg/event/mbi-spss-topography-sensing-by-endothelial-cells-role-of-ptp1b-by-azita-gorji/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Student & Postdoc Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20161130T150000
DTEND;TZID=UTC:20161130T160000
DTSTAMP:20260626T071656
CREATED:20161127T194028Z
LAST-MODIFIED:20161128T000749Z
UID:16224-1480518000-1480521600@www.mbi.nus.edu.sg
SUMMARY:MBI PhD Oral Defense: Study of Collective Cell Migration During Drosophila Middle Oogenesis by QIN Lei
DESCRIPTION:Speaker: QIN Lei (Graduate Student\, MBI\, NUS)\nDate: 30 November 2016\, Wednesday\nTime: 3pm\nVenue: MBI\, T-lab\, level 5 seminar rooms\nSupervisor(s): Asst. Prof Toyama Yusuke \nAbstract: Collective cell migration is a common and essential multicellular process that occurs during animal development\, tissue repair\, and cancer metastasis. The regulation and underlying mechanism of collective cell migration is the key to our understanding of both normal physiological processes and abnormal pathologies. The current working model for collective cell migration is the “leader-follower” paradigm\, in which leader cells are the force generator and major mechanical contributors for overall tissue movement. Comparing to the research focused on leader cells\, there are fewer studies focused on follower cells whose functions and contributions in the collective cell migration are yet to be revealed. \nIn this study\, live imaging combined with optogenetics was utilized to investigate follicle cell (FC) posterior migration during Drosophila middle oogenesis. While the FCs are composed of multiple subgroups\, studying the collective migration of different subgroups during middle oogenesis serves as an ideal platform for the investigation of contributions from follower cells. Among all the FC subgroups\, centripetal FCs were monitored and found to have the fastest migratory speed across the epithelium. This group of FCs was distributed\, according to their marker gene Slbo\, in a circumferential “band” pattern in the middle of the FC epithelium. Quantitative analyses of FC morphology and protein distribution along FC layers indicate a higher Rac and Ena accumulation on the apical surface of centripetal FCs. These accumulations have led to the appearance of dynamic protrusions and sharp apical angles in these cells. Moreover\, suppression of endogenous Rac activity by photo-activatable dominant-negative (DN) Rac in different FC subgroups showed a significant role for centripetal FCs in FC posterior migration. Specifically\, Rac suppression in centripetal FCs reduced migratory speed across the entire tissue. These results demonstrate a role for centripetal FCs in controlling FC migration\, including generation of forces to push mainbody FCs in front of centripetal FCs\, and forces to pull stretched FCs located behind. In addition\, RNA interference (RNAi) studies reveal that the Rac-dependent migration of centripetal FCs was controlled by PVR/EGFR signaling\, in response to the gurken ligand concentration gradient secreted from the posteriorly located oocyte. \nIn summary\, this study uncovers the active contributions of centripetal FCs in FC posterior migration during Drosophila middle oogenesis. This is remarkable since centripetal FCs are located in the middle of the tissue and considered as “follower cells”\, yet are equipped with higher migration ability in compared to surrounding cell types. They also act to physically push and pull neighboring cells for overall epithelial movement in response to the chemotactic signal generated by the oocyte. The work presented in this study will provide new insights into collective cell migration particularly in the context of contributions from follower cells\, and fill the knowledge gap in the current “leader-follower” model. \nALL EXCEPT PANEL ARE EXCUSED FOR CLOSE DOOR EXAMINATION
URL:https://www.mbi.nus.edu.sg/event/study-of-collective-cell-migration-during-drosophila-middle-oogenesis-by-qin-lei/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:PhD Oral Defense
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