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X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
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X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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DTSTART;TZID=Asia/Singapore:20191101T100000
DTEND;TZID=Asia/Singapore:20191101T110000
DTSTAMP:20260418T072059
CREATED:20191031T034223Z
LAST-MODIFIED:20191031T034223Z
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SUMMARY:MBIw: OrBID (OculaR BIomaterials and Device): A Biomaterials (polymer) platform providing clinical solutions for retinal disease by Dr Su Xinyi
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am -11.00am\nDate: Friday\, 1 Nov 2019\nVenue: Level 5 Seminar Room\, T-Lab \nOrBID (OculaR BIomaterials and Device): A Biomaterials (polymer) platform providing clinical solutions for retinal disease\nBy Dr Su Xinyi\, Institute of Molecular and Cell Biology\, A*STAR Singapore (hosted by A/Prof. Toyama Yusuke) \nOur research program aims to develop a hydrogel-based biomaterials platform to solve unmet clinical needs in ophthalmology. Our focus is on developing polymers for vitreo-retinal applications\, such as (i)  Vitreous substitutes: as internal tamponade agents after vitrectomy\, (ii) Sustained intravitreal drug delivery\, (iii) Retinal cellular therapeutics: surgical adjuncts for subretinal RPE transplantation. \nCurrent agents used for medium and long-term tamponade after vitreo-retinal surgery\, such as expansile gases and silicone oil\, have been around since the 1960s. Despite their inherent limitations\, they have not been replaced due to a lack of better alternatives. Sustained intravitreal drug delivery of biologics is the holy grail of ocular therapeutics. However\, a suitable drug delivery vehicle has remained elusive due to the lack of ideal biomaterials. Lastly\, stem cell transplantation is seen as the future of retinal therapeutics for treatment of age-related macular degeneration.  There is still a lack of suitable materials to generate multi-layer retinal tissues for functional transplantation. \nWe propose that hydrogels (hydrophilic polymers)\, which are optically clear and strongly resemble the natural vitreous\, are promising alternatives to existing materials. In collaboration with Dr Loh Xian Jun’s group at IMRE\, our team has the ability to synthesize a wide range of proprietary functional\, biodegradable and thermosensitive hydrogels. Of significance\, we have recently demonstrated that our thermogel is able function effectively as an internal tamponade using a non-human primate retinal detachment surgery model\, with no long-term toxicity to the retina. Our future work also includes studying how these hydrogel-based polymers affect retina intra-cellular functions\, and modulate cell-cell interaction.
URL:https://www.mbi.nus.edu.sg/event/mbiw-orbid-ocular-biomaterials-and-device-a-biomaterials-polymer-platform-providing-clinical-solutions-for-retinal-disease-by-dr-su-xinyi/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191115T100000
DTEND;TZID=Asia/Singapore:20191115T110000
DTSTAMP:20260418T072059
CREATED:20191111T052337Z
LAST-MODIFIED:20191111T052551Z
UID:27850-1573812000-1573815600@www.mbi.nus.edu.sg
SUMMARY:MBIw: Towards an innovative High Content Screening platform for organoids and its biomedical applications by Anne Beghin
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am – 11.00am\nDate: Friday\, 15 Nov 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nTowards an innovative High Content Screening platform for organoids and its biomedical applications\nBy Anne Beghin\, Senior Research Fellow\, Viasnoff Group\, Mechanobiology Institute \n 
URL:https://www.mbi.nus.edu.sg/event/mbiw-towards-an-innovative-high-content-screening-platform-for-organoids-and-its-biomedical-applications-by-anne-beghin/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191129T100000
DTEND;TZID=Asia/Singapore:20191129T110000
DTSTAMP:20260418T072059
CREATED:20191202T010742Z
LAST-MODIFIED:20191202T010742Z
UID:27913-1575021600-1575025200@www.mbi.nus.edu.sg
SUMMARY:MBIw: Spatio-temporal Organization and Dynamics of Human DNA Replication Foci Mediated by CTCF-organized Chromatin Structures by Ziqing (Winston) ZHAO
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am – 11.00am\nDate: Friday\, 29 Nov 2019\nVenue: Level 5 Meeting Room 1\, T-Lab \nSpatio-temporal Organization and Dynamics of Human DNA Replication Foci Mediated by CTCF-organized Chromatin Structures\nby Ziqing (Winston) ZHAO\, Department of Chemistry / Centre for BioImaging Sciences\, NUS
URL:https://www.mbi.nus.edu.sg/event/mbiw-spatio-temporal-organization-and-dynamics-of-human-dna-replication-foci-mediated-by-ctcf-organized-chromatin-structures-by-ziqing-winston-zhao/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
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