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X-WR-CALNAME:Mechanobiology Institute, National University of Singapore
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X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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DTSTART:20180101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190510T093000
DTEND;TZID=Asia/Singapore:20190510T103000
DTSTAMP:20260418T032811
CREATED:20190508T052135Z
LAST-MODIFIED:20190508T053203Z
UID:26443-1557480600-1557484200@www.mbi.nus.edu.sg
SUMMARY:MBIw: Repurposing Nature: Opportunities for Protein Assemblies at Interfaces by Lim Sierin
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 10 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nRepurposing Nature: Opportunities for Protein Assemblies at Interfaces\nby Prof. Lim Sierin\, Associate Dean and Associate Professor\, Nanyang Technological University (NTU) Singapore. \nNature provides us with an abundance of biological materials that we have been repurposing to suit our needs. In this talk\, I will highlight self-assembling protein subunits that form hollow cage-like structures\, called protein cages. Protein cages have been investigated as potential molecular carriers. However\, tuning the release rate of encapsulated molecules from these protein cages is a challenge. We hypothesize that by rationally modulating the protein-protein interactions between the protein cage subunits\, the release of molecular cargo from the lumen can be tuned. To test the hypothesis\, we introduced modifications at the intersubunit interface and the interaction surfaces between two molecules by introducing non-native histidines or substituting the interacting surfaces with other peptide sequences. The effects of the modifications were characterized at various pH-s. The results show that rational modifications of protein-protein interactions have implications on the self-assembly and hence\, release rate of the encapsulated molecules. \nIn recent studies\, we found that these protein cages form an ensemble that stabilize oil droplets in water by localizing at the oil-water interface and forming Pickering emulsion. However\, their behavior and structural integrity at this interface is rarely studied. Our works elucidate the unique behavior of the protein nanocages that is distinct from other small (monomeric/dimeric) proteins. The protein cage-stabilized emulsion is pH-responsive. \nIn conclusion\, protein cages can serve as an individual molecular carrier or as an ensemble that stabilizes an emulsion and present many opportunities that are yet to be explored.
URL:https://www.mbi.nus.edu.sg/event/repurposing-nature-opportunities-for-protein-assemblies-at-interfaces-by-lim-sierin/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190517T093000
DTEND;TZID=Asia/Singapore:20190517T103000
DTSTAMP:20260418T032811
CREATED:20190513T085035Z
LAST-MODIFIED:20190513T085035Z
UID:26460-1558085400-1558089000@www.mbi.nus.edu.sg
SUMMARY:MBIw: Quantification of membrane receptor complexes with single-molecule localization microscopy by Mike Heilemann
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 17 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nQuantification of membrane receptor complexes with single-molecule localization microscopy\nby Prof Mike Heilemann (hosted by Prof. Linda Kenney)\, Goethe University Frankfurt
URL:https://www.mbi.nus.edu.sg/event/mbiw-quantification-of-membrane-receptor-complexes-with-single-molecule-localization-microscopy-by-mike-heilemann/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190524T093000
DTEND;TZID=Asia/Singapore:20190524T103000
DTSTAMP:20260418T032811
CREATED:20190522T023058Z
LAST-MODIFIED:20190522T023058Z
UID:26519-1558690200-1558693800@www.mbi.nus.edu.sg
SUMMARY:MBIw: Information Content of Cortical Traveling Waves by Wu Min
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 24 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nInformation Content of Cortical Traveling Waves\nby Wu Min\, Associate Professor\, Mechanobiology Institute\, National University of Singapore \n  \nThank you!
URL:https://www.mbi.nus.edu.sg/event/mbiw-information-content-of-cortical-traveling-waves-by-wu-min/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20190531T093000
DTEND;TZID=Asia/Singapore:20190531T103000
DTSTAMP:20260418T032811
CREATED:20190527T064351Z
LAST-MODIFIED:20190527T064351Z
UID:26540-1559295000-1559298600@www.mbi.nus.edu.sg
SUMMARY:MBIw: Interplay between actin polymerization\, myosin IIA filaments\, microtubules\, and integrin adhesions in cell morphogenesis by Alexander Bershadsky
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 9.30am-10.30am\nDate: Friday\, 31 May 2019\nVenue: Level 5 Seminar Room\, T-Lab \nInterplay between actin polymerization\, myosin IIA filaments\, microtubules\, and integrin adhesions in cell morphogenesis\nby Prof. Alexander Bershadsky\, Professor and Principal Investigator\, Mechanobiology Institute\, National University of Singapore \n 
URL:https://www.mbi.nus.edu.sg/event/mbiw-interplay-between-actin-polymerization-myosin-iia-filaments-microtubules-and-integrin-adhesions-in-cell-morphogenesis-by-alexander-bershadsky/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Weekly Seminar
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