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X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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DTSTART:20150101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20160329T093000
DTEND;TZID=UTC:20160329T103000
DTSTAMP:20260417T144018
CREATED:20160330T012853Z
LAST-MODIFIED:20160330T012944Z
UID:12021-1459243800-1459247400@www.mbi.nus.edu.sg
SUMMARY:MBI Student & Postdoc Seminar: Remodeling of adhesion and redistribution of mechanical tensile forces during apoptosis in Drosophila epithelium
DESCRIPTION:Date: 29 March 2016\, Tuesday\nTime: 9.30am\nVenue: T-Lab Level 5 Seminar Room \nby  Teng Xiang \nAbstract\nHow epithelial apoptosis mechanically impacts the neighboring tissue is not fully understood. Live imaging of histoblast expansion\, which is a coordinated tissue replacement process during Drosophila metamorphosis\, show that apoptotic cells undergo rapid apical constriction. In the middle of this rapid apical constriction\, adherens junctions (AJs) between apoptotic and non-dying cells become disengaged. Concurrently\, tissue mechanical tension is transiently released. Contraction of a supra-cellular actomyosin cable forms in neighboring cells\, brings the non-dying cells together and further reshapes tissue tension toward the completion of cell extrusion. By genetically blocking caspase activity\, the characteristics of apoptotic cell extrusion\, including the reduction in the levels of E-cad and the rapid apical constriction are diminished. Here\, we conclude that a mechanical coordination between adhesion remodeling and tissue tension reshaping represents a mechanism of apoptotic cell extrusion.
URL:https://www.mbi.nus.edu.sg/event/mbi-student-postdoc-seminar-remodeling-of-adhesion-and-redistribution-of-mechanical-tensile-forces-during-apoptosis-in-drosophila-epithelium/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI Student & Postdoc Seminar
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