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X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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TZID:UTC
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DTSTART:20210101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20220908T160000
DTEND;TZID=UTC:20220908T170000
DTSTAMP:20260418T091254
CREATED:20220830T070928Z
LAST-MODIFIED:20220830T070928Z
UID:35150-1662652800-1662656400@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar
DESCRIPTION:MBI Seminar\nDate: 8 September 2022\, Thursday\nTime: 4pm\nVenue: Zoom \nNucleation and surface fluctuations of biomolecular condensates\nBy Shunsuke F. Shimobayashi\, Associate Professor\, Center for iPS Cell Research and Application (CiRA)\, Kyoto University (Host: Tetsuya Hiraiwa) \n\nAbstract \nThe diverse functions and homeostasis maintenance of cells and tissues are supported by dynamic communications between internal single molecules and organelles. Organelles have been thought to be separated by lipid membranes\, as represented by cell nuclei and mitochondria. However\, in recent years\, many organelles and molecular assemblies that do not have lipid membranes\, often called as biomolecular condensates\, have been discovered and reconsidered. They are formed through phase separation principles and are likely involved in important biological functions\, including gene expression and signaling; however\, we are still largely in the dark about the molecular and biophysical factors that govern where and when these condensates form in living cells. Using optogenetics to light-control the nucleation process\, we quantitatively analyzed it and revealed that the process can be described by the framework of classical nucleation theories. Moreover\, we found that locally concentrated biomolecular features (e.g. amino acid sequence) can tune the nucleation landscape. In this seminar\, in addition to the nucleation mechanism\, I will share the recent ongoing work on the interface fluctuation of biomolecular condensates. \nReference [1] S. F. Shimobayashi\, Pierre Ronceray\, David W. Sanders\, Mikko P. Haataja\, and C. P. Brangwynne\, Nucleation landscape of biomolecular condensates\, Nature\, 599 (7885)\, 503-506\, (2021) \n\nFind Help\nNon MBI staff who are interested in attending should contact Qiao Jing at mbilqj@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-9/
LOCATION:ZOOM webcast
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220921T100000
DTEND;TZID=UTC:20220921T110000
DTSTAMP:20260418T091254
CREATED:20220831T080651Z
LAST-MODIFIED:20220831T080701Z
UID:35152-1663754400-1663758000@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar
DESCRIPTION:MBI Seminar\nDate: 21 September 2022\, Wednesday\nTime: 10am\nVenue: Level 5 Seminar Room \nThe molecular basis of cellular evolution in understudied branches of the tree of life\nBy Gregory Jedd\, Temasek Life Sciences Laboratory & Department of Biological Sciences\, NUS\, Singapore (Host: Prof Rong Li) \n\nAbstract \nThe study of cell biology has largely been restricted to a small number of genetically amenable model systems and the investigation of core eukaryotic systems such as the cell division cycle\, membranous organelles\, cytoskeleton\, signalling\, homeostasis\, and metabolism. As a result\, there is good understanding of the highly conserved systems inherited from the last eukaryotic common ancestor (LECA). By contrast\, many branches of the tree of life are unamenable to genetic manipulation.  Thus\, the molecular systems that confer lineage-specific adaptations are relatively understudied and our understanding of the genetic basis of evolutionary transitions is at best patchy. The talk will focus on the investigation of three such adaptive systems: gravity sensing in the fungi\, the emergence of novel plastids in giant algal cells\, and the evolution of obligate heterotrophy in the diatoms. I will show how the molecular basis of these systems can be identified by combining comparative genomics and protein mass spectrometry with reconstitution and heterologous gene expression. The results suggest the ongoing evolution of complex adaptive traits at the genus and species level. The implications of this finding will be discussed. In general\, this approach can reveal the genetic basis of evolutionary transitions while also identifying new pathways and protein activities for application in biotechnology and synthetic biology \n\nFind Help\nNon MBI staff who are interested in attending should contact Qiao Jing at mbilqj@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/35152/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220929T150000
DTEND;TZID=UTC:20220929T160000
DTSTAMP:20260418T091254
CREATED:20220908T042813Z
LAST-MODIFIED:20220908T042813Z
UID:35229-1664463600-1664467200@www.mbi.nus.edu.sg
SUMMARY:MBI Seminar
DESCRIPTION:MBI Seminar\nDate: 29 September 2022\, Thursday\nTime: 3pm\nVenue: Level 5 Seminar Room \nNucleus size and its effect on nucleosome stability in living cells\nBy Artem Efremov\, Shenzhen Bay Laboratory\, China  (Host: Prof Yan Jie) \n\n\nFind Help\nNon MBI staff who are interested in attending should contact Qiao Jing at mbilqj@nus.edu.sg.
URL:https://www.mbi.nus.edu.sg/event/mbi-seminar-10/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
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