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X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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DTSTART:20180101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191007T160000
DTEND;TZID=Asia/Singapore:20191007T170000
DTSTAMP:20260417T131237
CREATED:20191003T090338Z
LAST-MODIFIED:20191003T090406Z
UID:27539-1570464000-1570467600@www.mbi.nus.edu.sg
SUMMARY:DNA and Anticancer Drugs Interactions Studied By Single-Molecule Manipulation by You Huijuan
DESCRIPTION:MBI Seminar\nProf You Huijuan\, hosted by Prof Yan Jie “DNA and Anticancer Drugs Interactions Studied By Single-Molecule Manipulation” on 7 Oct (Mon) @4pm T-Lab Level 5 Seminar Rooms
URL:https://www.mbi.nus.edu.sg/event/dna-and-anticancer-drugs-interactions-studied-by-single-molecule-manipulation-by-you-huijuan/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20191011T100000
DTEND;TZID=Asia/Singapore:20191011T110000
DTSTAMP:20260417T131237
CREATED:20191008T074113Z
LAST-MODIFIED:20191008T074247Z
UID:27592-1570788000-1570791600@www.mbi.nus.edu.sg
SUMMARY:MBIw: Single cell analysis to dissect cellular heterogeneity in complex systems by Cheow Lih Feng
DESCRIPTION:MBI Weekly Meeting Seminar\nTime: 10.00am -11.00am\nDate: Friday\, 11 October 2019\nVenue: Level 5 Seminar Room\, T-Lab \nSingle cell analysis to dissect cellular heterogeneity in complex systems\nBy Dr. Cheow Lih Feng\, Principal Investigator\, National University of Singapore \nHosted by Prof. Kanchanawong \nThe human body is an amazing feat where trillions of cells of different cell types work together seamlessly to enable specific functions. Understanding the molecular mechanisms of these different cells is the key to understanding the basis of human health and conditions that leads to disease. To date\, however\, biological measurements are largely applied to bulk cells\, which mask important cell-to-cell variations in tissues that give rise to diverse phenotypes. In this talk\, I will present several approaches that we have developed to dissect various aspects of cellular heterogeneity. I will describe the Single Cell Restriction Analysis of Methylation (SCRAM) method that can be used to assay for DNA methylation states in single cells. I will also describe how it can be extended to the Single Cell analysis of Genotype\, Expression and Methylation (sc-GEM) assay for multimodal analysis in single cells. Lastly I will present results from our latest DNA Analysis by Restriction Enzyme (DARE) assay that allows simultaneous genomic and epigenomic characterization of single cells. Applications for these assays will be presented.
URL:https://www.mbi.nus.edu.sg/event/mbiw-single-cell-analysis-to-dissect-cellular-heterogeneity-in-complex-systems-by-cheow-lih-feng/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
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