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X-ORIGINAL-URL:https://www.mbi.nus.edu.sg
X-WR-CALDESC:Events for Mechanobiology Institute, National University of Singapore
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TZID:Asia/Singapore
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DTSTART:20170101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20180912T160000
DTEND;TZID=Asia/Singapore:20180912T170000
DTSTAMP:20260418T030433
CREATED:20180827T033925Z
LAST-MODIFIED:20180827T033925Z
UID:24136-1536768000-1536771600@www.mbi.nus.edu.sg
SUMMARY:Mechanisms of mitosis and size control in Xenopus by Prof Rebecca Heald
DESCRIPTION:We are pleased to inform you on the seminar by Prof Rebecca Heald\, hosted by Prof Yan Jie “Mechanisms of mitosis and size control in Xenopus” on 12 Sep (Wed) @ 4pm at T-Lab Level 5 Seminar Rooms. \n \n 
URL:https://www.mbi.nus.edu.sg/event/mechanisms-of-mitosis-and-size-control-in-xenopus-by-prof-rebecca-heald/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20180920T150000
DTEND;TZID=Asia/Singapore:20180920T160000
DTSTAMP:20260418T030433
CREATED:20180919T092746Z
LAST-MODIFIED:20180919T092837Z
UID:24565-1537455600-1537459200@www.mbi.nus.edu.sg
SUMMARY:Turning micro-wells into artificial 3D micro-niches with combined biochemical and biophysical cues by Celine Marie Helene Stoecklin
DESCRIPTION:MBI PhD Oral Defense\nTime: 3pm\nDate:  Thursday\, 20 September 2018\nVenue: NUS Faculty of Engineering\, E3-06-12 \nSupervisors: Prof Virgile Viasnoff (Main supervisor)\, Prof Evelyn Yim (Co-supervisor) \nTurning micro-wells into artificial 3D micro-niches with combined biochemical and biophysical cues\nby Celine Marie Helene STOECKLIN\, Viasnoff Group \n  \nCells in a tissue are residing within an assembly of intertwined chemical and mechanical signals coming from the extracellular matrix\, cell–cell interactions and soluble factors. It is this complex and three-dimensional (3D) micro-environment that governs their behavior. Rapid progress has been made in the development of biomimetic culture systems aiming to recapitulate this complexity in vitro. All these tools have greatly advance our understanding of how cells sense their surrounding environment. Moreover\, these engineered artificial micro-environments provide good platforms to study biological processes and understand their underlying regulatory mechanisms under highly defined conditions. Whereas a large number of environmental cues can be reconstituted individually and mostly in two-dimension (2D)\, it remains challenging to control in a single technique any combination of these factors. \nIn the first part of the thesis\, we propose a novel approach to create 3D artificial micro-niches with more than 80 possible combinations of environ- mental factors. Using a UV protein printer and photo-reactive materials\, we demonstrate how the layering of polymeric membranes can be used to fabricate micro-niches with complex environmental properties. Our approach enables to bio-functionalized micro-wells in 3D simultaneously with protein patterns\, structured hydrogels and topographical features with 1 micrometer precision.  \nThe second part is dedicated to cell seeding and behavior inside these complex micro-niches. Focusing on single epithelial cell\, we demonstrate how fibronectin micro-patterned niches extend the capability to normalize cell internal organization in 3D. We then show that a specific micro-environment mimicking the in vivo conditions can trigger the apico-basal polarization of single hepatocytes. \nIn the last part\, we investigate the potential of our method to create complex micro-niches with multiple cell types at the organoid scale. To explore this topic\, we take the human hair follicle as a paradigm. Specifically\, the reciprocal epithelial-mesenchymal interaction necessary for hair growth is studied by monitoring the spatial organisation of human primary keratinocytes and dermal papilla cells of the hair follicle inside the micro- niches. \n  \n**Please note the examination following the seminar is closed-door** \n 
URL:https://www.mbi.nus.edu.sg/event/turning-micro-wells-into-artificial-3d-micro-niches-with-combined-biochemical-and-biophysical-cues-by-celine-marie-helene-stoecklin/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,PhD Oral Defense
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20180924T110000
DTEND;TZID=Asia/Singapore:20180924T120000
DTSTAMP:20260418T030433
CREATED:20180917T021439Z
LAST-MODIFIED:20180917T021439Z
UID:24495-1537786800-1537790400@www.mbi.nus.edu.sg
SUMMARY:Emergent Oscillations In Dense Adaptive Cell Populations by Prof Tang Leihan
DESCRIPTION:We are pleased to inform you on the seminar by Prof Tang Leihan\, hosted by Prof Yan Jie “Emergent Oscillations In Dense Adaptive Cell Populations” on 24 Sep (Mon) @11amat T-Lab Level 5 Seminar Rooms.
URL:https://www.mbi.nus.edu.sg/event/emergent-oscillations-in-dense-adaptive-cell-populations-by-prof-tang-leihan/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20180928T093000
DTEND;TZID=Asia/Singapore:20180928T103000
DTSTAMP:20260418T030433
CREATED:20180927T025309Z
LAST-MODIFIED:20181005T073206Z
UID:24720-1538127000-1538130600@www.mbi.nus.edu.sg
SUMMARY:MBIw: The JNK signaling links the CNS architectural organization to motor coordination in Drosophila by Dr. Enrique Martin-Blanco
DESCRIPTION:We are pleased to inform you on the seminar by Dr. Enrique Martin-Blanco\, hosted by Dr. Timothy Saunders “The JNK signaling links the CNS architectural organization to motor coordination in Drosophila” on 28 Sep (Frid) @ 9.30am at T-Lab Level 5 Seminar Rooms. Thank you.
URL:https://www.mbi.nus.edu.sg/event/the-jnk-signaling-links-the-cns-architectural-organization-to-motor-coordination-in-drosophila-by-dr-enrique-martin-blanco/
LOCATION:MBI Seminar Room Lvl 5\, T-Lab\, Level 5\, 5A Engineering Drive 1\, Mechanobiology Institute\, National University of Singapore\, 117411\, Singapore
CATEGORIES:MBI Seminar,MBI Weekly Seminar
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